4.6 Article

Orbitofrontal Cortex Functional Connectivity-Based Classification for Chronic Insomnia Disorder Patients With Depression Symptoms

期刊

FRONTIERS IN PSYCHIATRY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2022.907978

关键词

insomnia; depression; orbitofrontal cortex; functional connectivity; machine learning

资金

  1. Sichuan Provincial Science and Technology Department project in China [2020YJ0197, 2020YJ0176, 2021YJ0162, 2020YFS0486]
  2. National Natural Science Foundation of China [82001803]
  3. Chengdu Science and Technology Department project [2021-YF05-00247-SN]
  4. Hefei Municipal Health Commission and Collaborative Innovation Center for Neuropsychiatric Disorders and Mental Health [NDMHCI-19-01]
  5. Department of Science and Technology of Anhui Province [202004j07020006]

向作者/读者索取更多资源

This study used a machine learning approach to differentiate chronic insomnia disorder (CID) patients with depressive symptoms from those without depressive symptoms based on orbital frontal cortex (OFC) functional connectivity. The classification model based on OFC functional connectivity showed a total accuracy of 76.92%.
Depression is a common comorbid symptom in patients with chronic insomnia disorder (CID). Previous neuroimaging studies found that the orbital frontal cortex (OFC) might be the core brain region linking insomnia and depression. Here, we used a machine learning approach to differentiate CID patients with depressive symptoms from CID patients without depressive symptoms based on OFC functional connectivity. Seventy patients with CID were recruited and subdivided into CID with high depressive symptom (CID-HD) and low depressive symptom (CID-LD) groups. The OFC functional connectivity (FC) network was constructed using the altered structure of the OFC region as a seed. A linear kernel SVM-based machine learning approach was carried out to classify the CID-HD and CID-LD groups based on OFC FC features. The predict model was further verified in a new cohort of CID group (n = 68). The classification model based on the OFC FC pattern showed a total accuracy of 76.92% (p = 0.0009). The area under the receiver operating characteristic curve of the classification model was 0.84. The OFC functional connectivity with reward network, salience network and default mode network contributed the highest weights to the prediction model. These results were further validated in an independent CID group with high and low depressive symptom (accuracy = 67.9%). These findings provide a potential biomarker for early diagnosis and intervention in CID patients comorbid with depression based on an OFC FC-based machine learning approach.

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