期刊
FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.927513
关键词
Band keratopathy; hyperparathyroidism; case-controlled study; sociodemographic factors; Taiwan Longitudinal Health Insurance Database
This study found a significant association between hyperparathyroidism, chronic kidney disease (CKD), diabetes mellitus (DM), iridocyclitis, phthisis bulbi, and ever silicone oil retention with band keratopathy. Patients aged 65 years or older and those living in Eastern Taiwan and engaging in fishing had a higher risk of developing band keratopathy.
PurposeTo investigate the association of comorbidities including hyperparathyroidism and sociodemographic factors with band keratopathy. MethodsThis retrospective, population-based, matched case-control study recruited 2,545 patients suffering from band keratopathy. They were selected from the Taiwan National Health Insurance Research Database, based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code 371.43. The control group included 15,270 sex-, age-, and index date-matched non-band keratopathy patients collected from the Taiwan Longitudinal Health Insurance Database 2000. To compare band keratopathy patients with controls, McNemar's test was used for nominal data and paired t- tests were used for continuous variables. Univariate conditional logistic regression analysis and multivariable conditional logistic regression were used to obtain the odds ratio (OR) and adjusted OR of developing band keratopathy. ResultsPatients with hyperparathyroidism were more likely to develop band keratopathy than controls (OR, 43.5; 95% confidence interval [CI], 23.789-79.544; P < 0.001) even after conditional logistic regression (adjusted OR, 11.28; 95% CI, 5.461-23.33; P < 0.001). Other conditions that increased the odds of scleritis development included systemic diseases such as chronic kidney disease (CKD) and diabetes mellitus (DM) and ocular conditions such as iridocyclitis, phthisis bulbi, and ever silicone oil retention. Regarding sociodemographic factors, >40% of patients with band keratopathy were aged >= 65 years old. Moreover, patients living in Eastern Taiwan and fishermen had higher odds of developing band keratopathy. ConclusionsBand keratopathy is significantly associated with hyperparathyroidism, CKD, DM, iridocyclitis, phthisis bulbi, and ever silicone oil retention.
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