4.7 Article

Human Immunocompetent Model of Neuroendocrine Liver Metastases Recapitulates Patient-Specific Tumour Microenvironment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Three-Dimensional Primary Cell Culture: A Novel Preclinical Model for Pancreatic Neuroendocrine Tumors

Simon Leonhard April-Monn et al.

Summary: This study established a novel in vitro 3-dimensional human primary PanNET culture system as a preclinical model for personalized therapy selection. The platform allows multicenter sample collection and drug screening, showing that primary cells isolated from PanNET patients can form islet-like tumoroids in vitro and display varying therapeutic response profiles. The model is believed to be suitable for personalized drug testing in a larger patient cohort, aiding in identifying novel markers predicting treatment response and refining PanNET therapy.

NEUROENDOCRINOLOGY (2021)

Review Endocrinology & Metabolism

Models of Gastroenteropancreatic Neuroendocrine Neoplasms: Current Status and Future Directions

Katharina Detjen et al.

Summary: GEP-NENs are rare and heterogeneous tumors originating from the endocrine system of the gastrointestinal tract and pancreas. Limited data from large prospective clinical trials are available for treatment recommendations, which are mainly based on retrospective analyses or case series. More tractable disease models are needed to better understand and predict treatment response in patients.

NEUROENDOCRINOLOGY (2021)

Article Physiology

Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

Antonio Riva et al.

Summary: The study found that patients with alcohol-related liver disease exhibit abnormally elevated levels of soluble TIM3, especially those with more severe conditions. Soluble TIM3 is strongly correlated with pro-inflammatory cytokines, gut bacterial translocation markers, and disease severity indicators. In addition, bacterial challenge leads to the overexpression of membrane TIM3 on immune cells.

FRONTIERS IN PHYSIOLOGY (2021)

Article Oncology

The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer

Sebastian Meltzer et al.

Summary: The soluble form of the costimulatory immune checkpoint receptor cluster of differentiation molecule 40 (sCD40) was identified as a marker of liver metastasis risk in rectal cancer patients. Higher levels of sCD40 were associated with shorter time to liver metastasis, independent of lung metastasis progression. This marker may have potential for clinical use.

BRITISH JOURNAL OF CANCER (2021)

Article Endocrinology & Metabolism

Ex Vivo Modeling of Human Neuroendocrine Tumors in Tissue Surrogates

Brendon Herring et al.

Summary: This study proposes the use of an ex vivo 3D flow-perfusion bioreactor system for cultivating and studying patient-derived neuroendocrine tumors (NETs), demonstrating its utility and providing methods for evaluating therapeutic efficacy. The research suggests that the bioreactor system and similar 3D culture models may be valuable tools for culturing patient-derived NETs and monitoring their response to therapy ex vivo.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Chemistry, Medicinal

Activity and Safety of Immune Checkpoint Inhibitors in Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis

Alberto Bongiovanni et al.

Summary: Immune-checkpoint inhibitors (ICIs) have shown promising efficacy in neuroendocrine neoplasms, with combination regimens potentially superior to monotherapy. The good efficacy and safety profile of ICIs offer a valid opportunity for expanding the therapeutic landscape of NENs, although further research and predictive biomarkers are needed.

PHARMACEUTICALS (2021)

Article Oncology

Soluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patients

Devayani Machiraju et al.

Summary: Different mechanisms lead to resistance to immune checkpoint inhibitors in melanoma patients. Soluble immune checkpoints and T cell expression were analyzed, showing associations between certain markers and resistance to specific treatments, with potential implications for clinical use.

ONCOIMMUNOLOGY (2021)

Editorial Material Cell Biology

The 2019 WHO classification of tumours of the digestive system

Iris D. Nagtegaal et al.

HISTOPATHOLOGY (2020)

Article Substance Abuse

Perturbations in Mitochondrial Dynamics Are Closely Involved in the Progression of Alcoholic Liver Disease

Elena Palma et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2020)

Review Gastroenterology & Hepatology

Neuroendocrine liver metastases: a contemporary review of treatment strategies

Jordan M. Cloyd et al.

HEPATOBILIARY SURGERY AND NUTRITION (2020)

Article Oncology

Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles

Jacob J. Orme et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Biochemistry & Molecular Biology

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

Kenta Kawasaki et al.

Article Multidisciplinary Sciences

Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma

Sougat Misra et al.

SCIENTIFIC REPORTS (2019)

Review Pathology

Circulating biomarkers predictive of tumor response to cancer immunotherapy

Ernest Y. Lee et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2019)

Letter Genetics & Heredity

H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines

Tobias Hofving et al.

NATURE GENETICS (2019)

Review Pathology

Paget's Seed and Soil Theory of Cancer Metastasis: An Idea Whose Time has Come

Mohammed Akhtar et al.

ADVANCES IN ANATOMIC PATHOLOGY (2019)

Article Multidisciplinary Sciences

Genetic heterogeneity of primary lesion and metastasis in small intestine neuroendocrine tumors

Dirk Walter et al.

SCIENTIFIC REPORTS (2018)

Article Medicine, General & Internal

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

L. Horn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

Soluble immune checkpoints in cancer: production, function and biological significance

Daqian Gu et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Review Oncology

Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes

Aric . Colunga et al.

CLINICAL CANCER RESEARCH (2018)

Article Gastroenterology & Hepatology

Early Recurrence of Neuroendocrine Liver Metastasis After Curative Hepatectomy: Risk Factors, Prognosis, and Treatment

Xu-Feng Zhang et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2017)

Article Oncology

The Impact of PD-L1 Expression in Patients with Metastatic GEP-NETs

Seung Tae Kim et al.

JOURNAL OF CANCER (2016)

Article Multidisciplinary Sciences

Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides

Yuko Takano et al.

PLOS ONE (2015)

Article Oncology

Reconstructed Adeno-Associated Virus with the Extracellular Domain of Murine PD-1 Induces Antitumor Immunity

Osama A. O. Elhag et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2012)

Article Endocrinology & Metabolism

The Role of Cell Lines in the Study of Neuroendocrine Tumors

Simona Grozinsky-Glasberg et al.

NEUROENDOCRINOLOGY (2012)

Review Gastroenterology & Hepatology

A Multimodal Approach to the Management of Neuroendocrine Tumour Liver Metastases

Ron Basuroy et al.

INTERNATIONAL JOURNAL OF HEPATOLOGY (2012)

Letter Oncology

Varying Opinions on the Authenticity of a Human Midgut Carcinoid Cell Line - Letter

Lee M. Ellis et al.

CLINICAL CANCER RESEARCH (2010)

Article Oncology

Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors

Irvin M. Modlin et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)

Article Oncology

The development and characterization of a human midgut carcinoid cell line

George Van Buren et al.

CLINICAL CANCER RESEARCH (2007)

Article Multidisciplinary Sciences

A transgenic mouse model of metastatic carcinoma. involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype

AJ Syder et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)