4.7 Review

Hydrogen sulfide: A new therapeutic target in vascular diseases

期刊

FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.934231

关键词

hydrogen sulfide; vascular; hypertension; angiogenesis; atherosclerosis

资金

  1. Natural Science Foundation of China
  2. China Postdoctoral Science Foundation
  3. Special Fund of Jilin Province
  4. Jilin Provincial Finance Department, China
  5. Jilin Science and Technology Agency funds in China, China
  6. [82000390]
  7. [2020M681048]
  8. [2020SC2T038]
  9. [2020SCZT091]
  10. [20210402003GH]

向作者/读者索取更多资源

This review systematically summarizes the role of H2S in vascular diseases, including hypertension, atherosclerosis, inflammation and angiogenesis. It also outlines a novel therapeutic perspective involving the crosstalk between H2S and smooth muscle cell function.
Hydrogen sulfide (H2S) is one of most important gas transmitters. H2S modulates many physiological and pathological processes such as inflammation, oxidative stress and cell apoptosis that play a critical role in vascular function. Recently, solid evidence show that H2S is closely associated to various vascular diseases. However, specific function of H2S remains unclear. Therefore, in this review we systemically summarized the role of H2S in vascular diseases, including hypertension, atherosclerosis, inflammation and angiogenesis. In addition, this review also outlined a novel therapeutic perspective comprising crosstalk between H2S and smooth muscle cell function. Therefore, this review may provide new insight inH(2)S application clinically.

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