期刊
FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.917773
关键词
kidney; SIRT1; vascular calcification; chronic kidney disease; HIV infection
资金
- National Natural Science Foundation of China [2019-81973772]
The incidence and prevalence of chronic kidney disease (CKD) are increasing worldwide and pose a significant public health burden. SIRT1, a NAD+-dependent deacetylase, has protective effects on the kidney by regulating fibrosis, apoptosis, senescence, oxidative stress, inflammation, and aging. This narrative review provides an overview of the recent progress on the role of SIRT1 and its downstream pathways in CKD and discusses potential therapeutic approaches by activating the SIRT1-related pathway in CKD patients.
The incidence and prevalence of chronic kidney disease (CKD) continue to increase worldwide remaining as a major public health burden. CKD eventually progresses to end-stage kidney failure and patients with CKD have high morbidity and mortality. Sirtuin 1 (SIRT1), a NAD+-dependent deacetylases, has significant renal protective effects through its regulation of fibrosis, apoptosis, and senescence, oxidative stress, inflammation and aging process. The renal protective effects of Sirt1 have been described in many kidney diseases such as diabetic kidney disease and HIV-related kidney disease. SIRT1 also has protective effects against vascular calcification and therefore could be developed as a therapy for both CKD and CKD complications. In this narrative review, we will give an overview of the recent progress on the role of SIRT1 and its downstream pathways in CKD. We will also discuss potential therapeutic approach by activating SIRT1-related pathway in patients with CKD. The purpose is to hope to provide some insights on the future direction of the research in the field of SIRT1 for CKD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据