期刊
FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.924414
关键词
neuroendocrine cervical carcinoma; SEER database; metastasis; prognosis; survival
资金
- Jiangxi youth science fund project in China
- National Natural Science Foundation of China
- [20181BAB215029]
- [81960550]
This study investigated the patterns and prognosis of distant organ metastasis in neuroendocrine carcinoma of the cervix (NECC). The results showed that NECC was prone to single and multi-site metastases, and distant metastasis was an independent predictor of poor prognosis in NECC patients. Additionally, surgery, radiotherapy, and chemotherapy were found to improve the overall survival of patients with distant organ metastases.
BackgroundNeuroendocrine carcinoma of the cervix (NECC) is a rare pathological form of cervical cancer. The prognosis of NECC with distant organ metastases is unclear. In our study, the patterns and prognosis of distant organ metastasis of NECC were investigated. MethodsData were obtained from the surveillance epidemiology and end results (SEER) database from 2000 to 2018. Cox regression, Kaplan-Meier and log-rank analyses were conducted. ResultsNECC was prone to single and multi-site metastases. The median overall survival (OS) was greatly decreased in patients with distant metastasis (P < 0.0001). Other characteristics such as age >= 60 years, poorer grade, higher T stage, those without surgery, no radiotherapy, and no chemotherapy were predictors of poor prognosis. ConclusionsMetastasis is an independent prognostic factor for patients with NECC. Surgery, radiotherapy, and chemotherapy give an overall survival advantage for patients with distant organ metastases.
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