Respiratory Tract Infections in Diabetes - Lessons From Tuberculosis and Influenza to Guide Understanding of COVID-19 Severity

Review Biochemistry & Molecular Biology

Role of vitamin D in pathogenesis and severity of COVID-19 infection

Maryam Honardoost et al.

Summary: The risk of severe complications in COVID-19 patients is higher in individuals with low levels of vitamin D. Vitamin D supplementation may enhance the immune system and reduce the severity of the disease.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

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Article Medicine, General & Internal

Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19: a meta-analysis

Wen Wen et al.

Summary: This study conducted a meta-analysis on three new oral antivirals (molnupiravir, fluvoxamine, and Paxlovid) and their effects on mortality and hospitalization rates among COVID-19 patients. The results showed that these drugs were effective in reducing mortality and hospitalization rates by approximately 67%. Furthermore, the drugs did not increase adverse events, indicating good overall safety.

ANNALS OF MEDICINE (2022)

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Article Health Care Sciences & Services

Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality

Karen H. Seal et al.

Summary: This study aims to investigate the relationship between vitamin D status and COVID-19-related clinical outcomes. The results show a significant inverse dose-response relationship between continuous 25(OH)D concentrations and COVID-19-related hospitalization and mortality after adjusting for factors associated with both vitamin D deficiency and COVID-19 outcomes.

JOURNAL OF GENERAL INTERNAL MEDICINE (2022)

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Article Immunology

The immunoregulatory landscape of human tuberculosis granulomas

Erin F. McCaffrey et al.

Summary: This study used MIBI-TOF technology to map the immune responses within human tuberculosis granulomas, revealing the presence of local spatially coordinated immunoregulatory programs that may have implications for disease progression and treatment response.

NATURE IMMUNOLOGY (2022)

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Review Endocrinology & Metabolism

Greasing the inflammatory pathogenesis of viral pneumonias in diabetes

Michelle S. M. A. Damen et al.

Summary: Type 2 diabetes and obesity increase the severity of influenza and SARS-CoV-2 infection. The immune cell inflammatory response and function are affected by cellular metabolism in obesity and diabetes, but the role of tissue-specific inflammatory responses, mainly adipocytes, in these infections is still unclear.

OBESITY REVIEWS (2022)

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Review Endocrinology & Metabolism

Association between Statin Use and Poor Outcomes in COVID-19 Patients with Diabetes Mellitus: A Systematic Review

Jessica Audrey et al.

Summary: The available evidence suggests that statins may be safely administered to diabetic COVID-19 patients and confer benefits in terms of improving clinical outcomes. However, there is inconsistent evidence regarding the association between statin use and poor outcomes in COVID-19 patients.

CURRENT DIABETES REVIEWS (2022)

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Review Cardiac & Cardiovascular Systems

The Association Between the Use of Statins and Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-analysis

Chia Siang Kow et al.

Summary: The study updated the evidence on the effect of statins on the clinical outcomes of patients with COVID-19 and found that statin use was significantly associated with lower risks of all-cause mortality and severe illness in these patients.

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS (2022)

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Article Endocrinology & Metabolism

Does poor glycaemic control affect the immunogenicity of the COVID-19 vaccination in patients with type 2 diabetes: The CAVEAT study

Raffaele Marfella et al.

DIABETES OBESITY & METABOLISM (2022)

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Article Medicine, Research & Experimental

Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial

Miguel A. Villasis-Keever et al.

Summary: This study found that VD supplementation can effectively prevent SARS-CoV-2 infection in highly exposed healthcare workers, regardless of VD status. It also demonstrated good safety. VD supplementation increased serum levels of 25-hydroxyvitamin D3.

ARCHIVES OF MEDICAL RESEARCH (2022)

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Article Respiratory System

Host lipidome and tuberculosis treatment failure

Rupak Shivakoti et al.

Summary: This study investigated the association between host lipids and treatment failure in tuberculosis (TB) using unbiased lipidomics. The results showed that treatment failure was associated with lower levels of cholesteryl esters and oxylipin, and higher levels of ceramides and triglycerides at the baseline. A lipid signature with predictive accuracy for TB treatment failure was also identified.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Endocrinology & Metabolism

Vitamin D Levels Are Associated With Blood Glucose and BMI in COVID-19 Patients, Predicting Disease Severity

Luigi di Filippo et al.

Summary: This study aimed to evaluate the relationship between vitamin D (VD) levels and inflammatory response, body mass index (BMI), blood glucose, and disease severity in COVID-19 patients. The study found a close association between VD deficiency and high blood glucose, obesity, as well as worse inflammatory response and respiratory parameters.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Article Immunology

A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection

Minh Dao Ngo et al.

Summary: In tuberculosis patients, reduced expression of GPR183 in diabetes patients is associated with more severe tuberculosis. Mycobacterium tuberculosis infection leads to the production of oxidized cholesterols in the lung, facilitating the recruitment of immune cells expressing the oxysterol-sensing receptor GPR183 to the site of infection. The GPR183/oxysterol axis is blunted during dysglycemia, resulting in delayed macrophage recruitment.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Endocrinology & Metabolism

Vitamin D supplementation and COVID-19 risk: a population-based, cohort study

J. Oristrell et al.

Summary: In this large population-based study, it was observed that supplementation with cholecalciferol or calcifediol leading to serum 25OHD levels >= 30 ng/ml was associated with better COVID-19 outcomes.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2022)

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Article Public, Environmental & Occupational Health

Interim Estimates of 2021–22 Seasonal Influenza Vaccine Effectiveness — United States, February 2022

Jessie R. Chung et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

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Article Immunology

Immunogenicity of SARS-CoV-2 BNT162b2 Vaccine in People with Diabetes: A Prospective Observational Study

Eleni Papadokostaki et al.

Summary: The mRNA-based BNT162b2 vaccine showed high efficacy against severe SARS-CoV-2 infection. Limited data is available regarding the immune response in people with diabetes after vaccination with the BNT162b2 vaccine. This study found that almost 17% of participants with diabetes did not develop adequate immune response after the first dose, but the response became high and similar between participants with and without diabetes after the second dose, and remained stable even two months after the second dose. There was no significant difference in antibody levels between participants with and without diabetes throughout the study. At least two doses of the BNT162b2 vaccine are required for sufficient and sustainable immune response in people with diabetes.

VACCINES (2022)

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Article Biotechnology & Applied Microbiology

The intentions to get vaccinated against influenza and actual vaccine uptake among diabetic patients in Ningbo, China: identifying motivators and barriers

Lixia Ye et al.

Summary: This study in China found that although nearly half of diabetic patients expressed intention to receive influenza vaccination, the actual uptake rate was low. Factors such as free vaccination and vaccination history were positively associated with vaccine uptake. Strategies to increase vaccination intention by promoting healthcare workers' recommendation and implementing government-funded free vaccination programs are needed to improve vaccine uptake among diabetic patients.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

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Article Microbiology

Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

Harindra D. Sathkumara et al.

Summary: There is a difference in the efficacy of MET against tuberculosis in diabetic and nondiabetic individuals, which warrants further investigation.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Review Nutrition & Dietetics

Dietary recommendations during the COVID-19 pandemic

Christianne de Faria Coelho-Ravagnani et al.

Summary: This review highlights the importance of optimal nutrition in improving well-being and reducing the risk of COVID-19, with a focus on consuming fruits, vegetables, whole grains, and essential minerals and vitamins. Dietary supplementation is not directly linked to COVID-19 prevention, but certain supplements may benefit individuals with respiratory viral infections or nutrient deficiencies. Hygiene practices for food handling are recommended to prevent transmission of COVID-19. Breastfeeding recommendations remain unchanged for women with COVID-19.

NUTRITION REVIEWS (2021)

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Review Pharmacology & Pharmacy

An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

Sylwester Drozdzal et al.

Summary: The COVID-19 pandemic poses a significant threat to global health with various therapeutic agents initially proclaimed to be effective, but later disproved. The Pfizer agent PAXLOVIDTM has shown promising results in reducing hospitalization time and death rates. Further development of additional treatments is needed due to the insufficiency of current recommended therapeutic options.

DRUG RESISTANCE UPDATES (2021)

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Letter Endocrinology & Metabolism

The role of obesity in inflammatory markers in COVID-19 patients

Jenna N. McNeill et al.

Summary: This study found that obese individuals hospitalized with COVID-19 exhibit a more exuberant inflammatory response and worse clinical outcomes, including higher levels of inflammatory markers and higher mortality rates.

OBESITY RESEARCH & CLINICAL PRACTICE (2021)

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Article Immunology

Human monocyte-derived macrophage responses to M. tuberculosis differ by the host's tuberculosis, diabetes or obesity status, and are enhanced by rapamycin

Blanca Restrepo et al.

Summary: The study found that MDMs from TB patients had reduced activation of T cells or killing of M. tuberculosis, while MDMs from obese participants had higher antigen presenting capacity and those from chronic diabetes patients had lower Mtb killing capacity. Activation of MDMs with rapamycin enhanced anti-mycobacterial activity regardless of TB status, but was less effective in patients with diabetes.

TUBERCULOSIS (2021)

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Article Immunology

Chronic Hyperglycemia Drives Functional Impairment of Lymphocytes in Diabetic INSC94Y Transgenic Pigs

Isabella-Maria Giese et al.

Summary: The study found reduced proliferative response in T cells and distinct changes in protein abundances in CD4(+) T cells of diabetic pigs. Additionally, altered metabolic immune cell phenotype with increased mitochondrial oxygen consumption rate and higher basal glycolytic activity was observed in PBMC of diabetic pigs. The research provides new insights into molecular mechanisms of dysregulated immune cells triggered by permanent hyperglycemia.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Hematology

Diabetes and Metabolic Drivers of Trained Immunity New Therapeutic Targets Beyond Glucose

Robin P. Choudhury et al.

Summary: Physiological functions are intricately intertwined, with evidence from immunometabolism field showing that cells can be programmed by changes in metabolic environment through epigenetic modifications, causing persistent changes. Understanding these processes can have significant implications for the diagnosis and treatment of diabetes and related metabolic states.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

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Article Respiratory System

The cumulative dose-dependent effects of metformin on the development of tuberculosis in patients newly diagnosed with type 2 diabetes mellitus

Eunyoung Heo et al.

Summary: This retrospective cohort study showed that only the highest cumulative doses of metformin were protective against the development of TB among patients newly diagnosed with type 2 DM; lower cumulative doses of metformin did not appear to reduce the incidence of active TB infection.

BMC PULMONARY MEDICINE (2021)

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Article Biology

De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

Thomas Laval et al.

Summary: The research revealed that Mtb has the ability to acquire specific fatty acids through Mce1 importer protein, while infected macrophages increase the synthesis of omega 6 PUFAs during the antiviral process, but this does not affect host cells or Mtb growth.

ELIFE (2021)

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Article Immunology

The Effect of Diabetes and Prediabetes on Mycobacterium tuberculosis Transmission to Close Contacts

Maria B. Arriaga et al.

Summary: This study investigated the epidemiological and clinical characteristics of patients with pulmonary tuberculosis and their close contacts. The results showed that contacts of persons with pulmonary tuberculosis and dysglycemia were at increased risk of being QuantiFERON positive, highlighting the importance of focusing on such close contacts for tuberculosis control.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Review Multidisciplinary Sciences

Pathological findings in organs and tissues of patients with COVID-19: A systematic review

Sasha Peiris et al.

Summary: The main pathological findings of severe/fatal COVID-19 infection include diffuse alveolar damage (DAD), changes related to coagulopathy and/or hemodynamic compromise. Additionally, myocarditis may be associated with sequelae according to the observed organ damage.

PLOS ONE (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

Yuchen Zhang et al.

Summary: The study demonstrates that SARS-CoV-2 infection alters host cell metabolism to support viral replication, with a clear sensitivity to inhibitors of folate and one-carbon metabolism. Targeted therapy focusing on host metabolism may be a valuable tool in fighting future coronavirus outbreaks.

NATURE COMMUNICATIONS (2021)

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Article Cardiac & Cardiovascular Systems

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

Laurienne Edgar et al.

Summary: The study found that hyperglycemia-induced trained immunity may explain the ineffectiveness of targeting elevated glucose in reducing macrovascular risk in diabetes, and suggests new targets for disease prevention and therapy.

CIRCULATION (2021)

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Article Multidisciplinary Sciences

Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort

Yong Suk Jo et al.

Summary: The study found a significant inverse association between total cholesterol level and risk of tuberculosis, with low total cholesterol level associated with increased TB risk, especially in younger subjects and those without diabetes or obesity.

SCIENTIFIC REPORTS (2021)

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Review Endocrinology & Metabolism

Mortality Risk of Antidiabetic Agents for Type 2 Diabetes With COVID-19: A Systematic Review and Meta-Analysis

Chengxia Kan et al.

Summary: The systematic review and meta-analysis found that metformin and sulfonylurea use were associated with lower mortality risk in patients with type 2 diabetes who have COVID-19, while insulin use was linked to higher mortality. There was no significant difference in mortality between DPP-4 inhibitor users and non-users, indicating a need for further exploration of the effects of antidiabetic agents in this population.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Review Endocrinology & Metabolism

Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression

Indriwanto Sakidjan Atmosudigdo et al.

Summary: This study found that dyslipidemia may increase the mortality and severity of COVID-19, especially in patients of older age, male gender, and with hypertension.

CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES (2021)

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Review Peripheral Vascular Disease

COVID-19 and diabetes: A bidirectional relationship

Marcos M. Lima-Martinez et al.

Summary: There is a bidirectional relationship between COVID-19 and diabetes mellitus, with diabetic individuals infected with SARS-CoV-2 having higher rates of hospital admission, severe pneumonia, and mortality compared to non-diabetic individuals. Chronic hyperglycemia and inflammatory state may lead to an exaggerated inflammatory response and increase the risk of acute respiratory distress syndrome.

CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS (2021)

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Article Respiratory System

Clinical and Radiological Presentations of Various Pulmonary Infections in Hospitalized Diabetes Mellitus Patients: A Prospective, Hospital-Based, Comparative, Case Series Study

Pravesh Vishwakarma et al.

Summary: The study found that there are differences in clinical presentation between diabetic and non-diabetic patients with lower respiratory tract infections. Diabetics tend to be older, have higher blood sugar levels, extreme temperatures, lower serum sodium levels, and lower partial arterial pressure than non-diabetic patients. They also commonly exhibit bilateral lesions in radiography.

PULMONARY MEDICINE (2021)

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Article Respiratory System

Association of Vitamin D Deficiency and Newly Diagnosed Pulmonary Tuberculosis

Vijay Jaimni et al.

Summary: The study identified a high prevalence of vitamin D deficiency in pulmonary tuberculosis patients, which was associated with more severe clinical symptoms, higher sputum smear positivity, and extensive lesions on chest radiographs.

PULMONARY MEDICINE (2021)

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Review Endocrinology & Metabolism

COVID-19 and diabetes mellitus: from pathophysiology to clinical management

Soo Lim et al.

Summary: Initial studies have shown that patients with diabetes mellitus have a higher risk of severe COVID-19, potentially due to hyperglycaemia affecting immune and inflammatory responses. Further investigation is needed to determine the optimal management for patients with diabetes mellitus during the ongoing pandemic.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Review Immunology

T-cell activation and cardiovascular risk in adults with type 2 diabetes mellitus: A systematic review and meta-analysis

Tawanda Maurice Nyambuya et al.

CLINICAL IMMUNOLOGY (2020)

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Article Virology

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

Yushun Wan et al.

JOURNAL OF VIROLOGY (2020)

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Letter Infectious Diseases

An interactive web-based dashboard to track COVID-19 in real time

Ensheng Dong et al.

LANCET INFECTIOUS DISEASES (2020)

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Review Nutrition & Dietetics

A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection

Adrian F. Gombart et al.

NUTRIENTS (2020)

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Article Cell Biology

Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21

Emer E. Hackett et al.

CELL REPORTS (2020)

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Article Biochemistry & Molecular Biology

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

Bo Shen et al.

CELL (2020)

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Article Cell Biology

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

Lihua Zhu et al.

CELL METABOLISM (2020)

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Letter Immunology

Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission

Jennifer Lighter et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Editorial Material Immunology

Immunometabolism: From basic mechanisms to translation INTRODUCTION

Liza Makowski et al.

IMMUNOLOGICAL REVIEWS (2020)

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Article Medicine, General & Internal

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Safiya Richardson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Letter Medicine, General & Internal

Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection

Giacomo Spinato et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Microbiology

Glycemic Variability in Diabetes Increases the Severity of Influenza

Rebecca J. Marshall et al.

MBIO (2020)

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Article Medicine, General & Internal

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

Yeming Wang et al.

LANCET (2020)

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Article Immunology

Increased susceptibility to Mycobacterium tuberculosis infection in a diet-induced murine model of type 2 diabetes

Mohammad Abdul Alim et al.

MICROBES AND INFECTION (2020)

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Article Multidisciplinary Sciences

Plasma metabolomic and lipidomic alterations associated with COVID-19

Di Wu et al.

NATIONAL SCIENCE REVIEW (2020)

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Article Medicine, General & Internal

被撤回的出版物: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 (Publication with Expression of Concern. See vol. 382, pg. 2464, 2020) (Retracted article. See vol. 382, pg. 2582, 2020)

Mandeep R. Mehra et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Immunology

Impact of Influenza Vaccination on All-Cause Mortality and Hospitalization for Pneumonia in Adults and the Elderly with Diabetes: A Meta-Analysis of Observational Studies

Angela Bechini et al.

VACCINES (2020)

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Article Endocrinology & Metabolism

COVID-19 and diabetes: Insulin requirements parallel illness severity in critically unwell patients

Linda Wu et al.

CLINICAL ENDOCRINOLOGY (2020)

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Article Endocrinology & Metabolism

Managing Hyperglycemia in the COVID-19 Inflammatory Storm

Roma Gianchandani et al.

DIABETES (2020)

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Article Endocrinology & Metabolism

Influenza Vaccination Is Associated With Reduced Cardiovascular Mortality in Adults With Diabetes: A Nationwide Cohort Study

Daniel Modin et al.

DIABETES CARE (2020)

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Review Endocrinology & Metabolism

Vitamin D and COVID-19

John P. Bilezikian et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2020)

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Review Immunology

The COVID-19 Cytokine Storm; What We Know So Far

Dina Ragab et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

Chaofu Wang et al.

EBIOMEDICINE (2020)

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Article Endocrinology & Metabolism

Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study

Bess Dawson-Hughes et al.

DIABETES CARE (2020)

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Article Medicine, Research & Experimental

Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severeCOVID-19 in type 2 diabetes

Fawaz Alzaid et al.

EMBO MOLECULAR MEDICINE (2020)

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Article Multidisciplinary Sciences

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

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Review Endocrinology & Metabolism

Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications

Eleftheria Papachristoforou et al.

JOURNAL OF DIABETES RESEARCH (2020)

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Article Critical Care Medicine

Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China

Zhilin Zeng et al.

CRITICAL CARE (2020)

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Review Immunology

Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection

Chaeuk Chung et al.

IMMUNE NETWORK (2020)

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Review Medicine, General & Internal

A Review of Postmortem Finding in Patients With COVID-19

Adenike O. Eketunde et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Adjunctive vitamin A and D during pulmonary tuberculosis treatment: a randomized controlled trial with a 2 x 2 factorial design

Jinyu Wang et al.

FOOD & FUNCTION (2020)

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Article Immunology

Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

Ekta Lachmandas et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

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Article Microbiology

Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction

Frank Vrieling et al.

PLOS PATHOGENS (2019)

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Article Infectious Diseases

Interaction of nutritional status and diabetes on active and latent tuberculosis: a cross-sectional analysis

Rachel W. Kubiak et al.

BMC INFECTIOUS DISEASES (2019)

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Article Immunology

Type 2 diabetes is associated with the accumulation of senescent T cells

E. Y. M. Lau et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2019)

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Review Immunology

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

Triantafyllos Chavakis et al.

NATURE IMMUNOLOGY (2019)

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Review Immunology

Western Diet and the Immune System: An Inflammatory Connection

Anette Christ et al.

IMMUNITY (2019)

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Article Endocrinology & Metabolism

Senescent T Cells Predict the Development of Hyperglycemia in Humans

Yong-ho Lee et al.

DIABETES (2019)

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Article Virology

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

Bingpeng Yan et al.

VIRUSES-BASEL (2019)

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Review Medicine, General & Internal

Type 2 Diabetes Mellitus and Altered Immune System Leading to Susceptibility to Pathogens, Especially Mycobacterium tuberculosis

Steve Ferlita et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Anette Christ et al.

CELL (2018)

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Article Endocrinology & Metabolism

Diabetes is associated with increased prevalence of latent tuberculosis infection: Findings from the National Health and Nutrition Examination Survey, 2011-2012

Marissa M. Barron et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

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Article Respiratory System

Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland

Charlotte Warren-Gash et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

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Article Immunology

Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny

Lu Huang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Article Medicine, General & Internal

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection

Jeffrey C. Kwong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Biotechnology & Applied Microbiology

Immunogenicity, safety, and effectiveness of seasonal influenza vaccination in patients with diabetes mellitus: A systematic review

Gael Dos Santos et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

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Article Microbiology

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-gamma/HIF-1 alpha signaling and supports host defense

Matthew Knight et al.

PLOS PATHOGENS (2018)

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Article Endocrinology & Metabolism

Glycemic Control and Risk of Infections Among People With Type 1 or Type 2 Diabetes in a Large Primary Care Cohort Study

Julia A. Critchley et al.

DIABETES CARE (2018)

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Article Microbiology

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes

Nicole C. Howard et al.

NATURE MICROBIOLOGY (2018)

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Review Immunology

Beyond Killing Mycobacterium tuberculosis: Disease Tolerance

Maziar Divangahi et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Endocrinology & Metabolism

Association between glycaemic control and common infections in people with Type 2 diabetes: a cohort study

J. L. Hine et al.

DIABETIC MEDICINE (2017)

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Article Clinical Neurology

METB-08. INCREASING GLUCOSE CONCENTRATIONS IS DELETERIOUS TO Th1 AND CYTOTOXIC T CELLS

Amber Giles

NEURO-ONCOLOGY (2017)

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CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis

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Diabetes mellitus is associated with cavities, smear grade, and multidrug-resistant tuberculosis in Georgia

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Statin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation

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Hypercholesterolemic LDL receptor-deficient mice mount a neutrophilic response to tuberculosis despite the timely expression of protective immunity

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Non-Diabetic Hyperglycemia Exacerbates Disease Severity in Mycobacterium tuberculosis Infected Guinea Pigs

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Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey

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Hypercholesterolemia impairs immunity to tuberculosis

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Respiratory Epithelial Cells Convert Inactive Vitamin D to Its Active Form: Potential Effects on Host Defense

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Cutting edge:: Vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin

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A cholesterol-rich diet accelerates bacteriologic sterilization in pulmonary tuberculosis

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High prevalence of hypovitaminosis D in female type 2 diabetic population

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Respiratory Tract Infections in Diabetes - Lessons From Tuberculosis and Influenza to Guide Understanding of COVID-19 Severity

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