4.7 Article

Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results From the DiViD Study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors

Laura Nigi et al.

Summary: The interaction between genetic and environmental factors determines the development of type 1 diabetes. Some viruses can infect and damage pancreatic beta cells, and MDA5 may play a role in the response of pancreatic islets to viral infections. In T1D donors, MDA5 expression is increased and may characterize dedifferentiated or newly forming islet cells.

FRONTIERS IN IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes

Paola S. Apaolaza et al.

Summary: The study reveals the presence of IFN response markers in the islets of T1D patients, which may lead to inflammation and impair beta cell function. Therapeutic interventions targeting the elimination of persistent infections and reduction of inflammation are crucial for individuals with T1D.

SCIENCE ADVANCES (2021)

Article Biochemistry & Molecular Biology

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes

Kendra Vehik et al.

NATURE MEDICINE (2019)

Article Pharmacology & Pharmacy

Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention

Sarah J. Richardson et al.

CURRENT OPINION IN PHARMACOLOGY (2018)

Article Endocrinology & Metabolism

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

Sarah J. Richardson et al.

DIABETOLOGIA (2016)

Article Endocrinology & Metabolism

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

Martha Campbell-Thompson et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2012)

Article Endocrinology & Metabolism

Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes

Sami Oikarinen et al.

DIABETES (2011)

Review Medicine, General & Internal

Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies

Wing-Chi G. Yeung et al.

BMJ-BRITISH MEDICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

Mechanism of PKR activation by dsRNA

Peter A. Lemaire et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

Review Immunology

Interferon-inducible antiviral effectors

Anthony J. Sadler et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Virology

Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method

A. Elfaitouri et al.

JOURNAL OF MEDICAL VIROLOGY (2007)

Review Immunology

Viruses and interferon: A fight for supremacy

MG Katze et al.

NATURE REVIEWS IMMUNOLOGY (2002)