期刊
FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.892125
关键词
dyslipidemia; lipid profiles; hyperandrogenism; insulin resistance; dysglycemia; PCOS
资金
- Natural Science Foundation of Shanghai [19ZR1406700]
- National Natural Science Foundation of China [81871143, 2071642]
This retrospective study examined lipid profiles in women with polycystic ovary syndrome (PCOS) and assessed the correlation between changes in key lipid parameters and PCOS characteristics. The study found a high prevalence of dyslipidemia in Chinese PCOS patients, with different lipid profiles observed in individuals with different PCOS characteristics. The findings suggest a complex relationship between lipid metabolism and PCOS characteristics, which may explain the increased risk of long-term cardiovascular disease. Regular screening of blood lipids is important for PCOS women, and further research is needed to identify optimal subgroups for lipid-lowering treatment and assess therapeutic effectiveness.
PurposeTo exhibit the lipid profiles in PCOS women with different characteristics and to access correlations between alternation of key lipid parameters and characteristics of PCOS. DesignA retrospective study. ParticipantsA total of 700 PCOS women were included. MethodsRetrospective study on 700 women (age 24.6 +/- 4.7 years), diagnosed with PCOS in the outpatient department of Obstetrics and Gynecology Hospital of Fudan University according to Rotterdam criteria. Anthropometric features, hormone levels, lipid levels, and metabolic parameters were measured and compared between PCOS patients with different characteristics. ResultsThere was a high prevalence of dyslipidemia among Chinese PCOS patients (41.3%), and the most common pattern was low HDL. Patients with clinical hyperandrogenism presented with significantly decreased HDL and Apo-A levels. The levels of TG, LDL, Apo-B, TG/HDL, and Apo-B/Apo-A were significantly increased in the insulin resistance subgroup. The levels of TC and TG were significantly increased in the dysglycemia and T2DM women. And in general, the levels of TG, and Apo-B had an increasing trend with BMI. Moreover, AI, TG/HDL, and Apo-B/Apo-A ratios were associated with some characteristics of PCOS, such as insulin resistance, and obesity. ConclusionThe PCOS women with different characteristics presented with different lipid profiles, and there is a complex correlation between lipid metabolism and PCOS characteristics, which may explain the increased risk of long-term cardiovascular disease. Regular screening of blood lipids is essential for PCOS women. Identification of optimal subgroups in PCOS patients that need lipid-lowering treatment and therapeutic effectiveness is worth exploring.
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