Necroptosis-Related Genes Associated With Immune Activity and Prognosis of Colorectal Cancer

Article Oncology

B cell-related gene signature and cancer immunotherapy response

Arian Lundberg et al.

Summary: The study revealed that the prognostic impact of tumor-infiltrating B cells depends on the status of cytokine signaling genes, which can predict response to cancer immunotherapy.

BRITISH JOURNAL OF CANCER (2022)

添加到收藏夹

Article Oncology

Identification and quantification of immune infiltration landscape on therapy and prognosis in left- and right-sided colon cancer

Jun-Nan Guo et al.

Summary: The study aimed to identify immune cell infiltration (ICI) subtypes for evaluating prognosis and therapeutic benefits in left-sided and right-sided colon cancer. High ICI scores were associated with increased tumor mutation burden (TMB) and genomic instability related signaling pathways. The study found significant differences in prognosis, sensitivities to targeted inhibitors and immunotherapy, IPS, and expression of immune checkpoints between high and low ICI score groups, with key genes including CA2 and TSPAN1 identified by ICI scores at various levels.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

添加到收藏夹

Review Oncology

Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy

Myriam Ben Khelil et al.

Summary: CD4(+) T cells play a crucial role in antitumor immunity, either by promoting or suppressing cytotoxic T cell responses. This review highlights the role of CD4(+) T subsets within the tumor microenvironment and discusses the latest developments in modulating CD4(+) T responses for cancer immunotherapy and improving cancer strategies.

CANCERS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comprehensive Analysis of Necroptosis-Related Long Noncoding RNA Immune Infiltration and Prediction of Prognosis in Patients With Colon Cancer

Li Liu et al.

Summary: This study identified necroptosis-related lncRNAs in colon cancer patients and found that these lncRNAs can predict patient survival and tumor immunity. They may have implications for personalized cancer therapy.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

添加到收藏夹

Article Cell Biology

An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis

Yan-Jie Chen et al.

Summary: This study reveals the prognostic value of mitochondrial SLC25 in patients with colon cancer and provides direction for further functional and mechanistic studies on the identified member of SLC25 through validation research.

CELL DEATH & DISEASE (2022)

添加到收藏夹

Article Cell Biology

Prognostic model and nomogram construction based on autophagy signatures in lower grade glioma

Chunhui Wang et al.

Summary: The study established a prognostic risk score model based on seven ATG genes for LGG, showing significant differences in overall survival between high and low risk patients. The final prognostic model, incorporating age, WHO grade, 1p19q codeletion status, and ATG risk score, was validated as an independent prognostic indicator and a nomogram for individualized survival prediction.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

RIPK3 signaling and its role in the pathogenesis of cancers

Shanhui Liu et al.

Summary: RIPK3 is a serine/threonine-protein kinase that plays key roles in inflammation and necrosis, potentially with different effects in cancer pathogenesis. It is involved in regulating various cellular processes such as apoptosis, mitochondrial metabolism, and cell proliferation.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Potential role of tumor-infiltrating T-, B-lymphocytes, tumor-associated macrophages and IgA-secreting plasma cells in long-term survival in the rectal adenocarcinoma patients

Dmitry A. Zinovkin et al.

Summary: This study investigated the expressions and roles of immune cells in the rectal cancer microenvironment and found that T lymphocytes, B lymphocytes, and IgA+ plasma cells were significantly associated with patient outcomes. The findings suggest a potential prognostic role of TIL-B and IgA+ PC in long-term survival of rectal cancer patients, with implications for cancer immunotherapy.

LIFE SCIENCES (2021)

添加到收藏夹

Review Immunology

The Therapeutic Potential of Tackling Tumor-Induced Dendritic Cell Dysfunction in Colorectal Cancer

Beatriz Subtil et al.

Summary: Colorectal cancer is the third most common malignancy worldwide, with limited treatment effects for metastatic CRC patients and untreatable cancer metastasis being the main cause of most CRC deaths. Research shows that CRC creates an immunosuppressive tumor microenvironment to hinder immune clearance of tumors, with dysfunction of dendritic cells playing a crucial role in tumor growth and metastasis.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Oncology

Necroptosis-Related lncRNAs: Predicting Prognosis and the Distinction between the Cold and Hot Tumors in Gastric Cancer

Zirui Zhao et al.

Summary: This study constructed a model with necroptosis-related lncRNAs to predict prognosis and aid in precision medication for gastric cancer patients. Analysis of IC50 differences between risk groups and clustering helped effectively distinguish between cold and hot tumors, contributing to precise mediation.

JOURNAL OF ONCOLOGY (2021)

添加到收藏夹

Article Oncology

Development of a novel necroptosis-associated miRNA risk signature to evaluate the prognosis of colon cancer patients

Yang Huang et al.

Summary: This study established a novel necroptosis-related miRNA risk signature to evaluate the prognosis of COAD patients. Functional enrichment analysis and nomograms demonstrated the critical role of these miRNAs in cancer development, metastasis, and prognosis. Target genes associated with the OS in COAD patients were identified for the necroptosis-related miRNAs.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Biochemical Research Methods

oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

Danielle Maeser et al.

Summary: Cell line drug screening datasets can be used for various drug discovery applications, including correcting drug sensitivity levels, predicting clinical drug response, and associating predictions with clinical features for drug biomarker discovery. These methodologies have been unified and updated into the OncoPredict R package to facilitate tool development and adoption, applicable for drug and biomarker discovery in various in vitro and in vivo contexts.

BRIEFINGS IN BIOINFORMATICS (2021)

添加到收藏夹

Article Oncology

Ferroptosis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma

Ting Lei et al.

Summary: This study identified molecular subgroups with different expression patterns of ferroptosis-related genes in osteosarcoma patients and found that the interaction between ferroptosis and immunity may impact the prognosis of patients. Functional analysis highlighted the enrichment of immunity-related signaling pathways, suggesting a potential role of ferroptosis-related genes in regulating the immune microenvironment of osteosarcoma and influencing patient outcomes.

CANCER SCIENCE (2021)

添加到收藏夹

Review Immunology

Promising New Tools for Targeting p53 Mutant Cancers: Humoral and Cell-Based Immunotherapies

Vitaly Chasov et al.

Summary: Mutations in the p53 protein result in loss of transcriptional functions, leading to deactivation of tumor suppressive responses and acquisition of pro-oncogenic properties. Hotspot mutations of p53 are often immunogenic, eliciting T cell responses to mutant p53 neoantigens.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Oncology

Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses

Allan Scarpitta et al.

Summary: Cancer, the second leading cause of death globally, is often treated with chemotherapeutic drugs which can have side effects, but some of these drugs can stimulate anti-tumor immune responses through the induction of immunogenic cell death. The study discusses the potential of inducing different forms of ICD to enhance immunogenicity and stimulate effective anti-tumor immune responses.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Immunology

Tumor Immunology and Tumor Evolution: Intertwined Histories

Jerome Galon et al.

IMMUNITY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5

Yohei Ando et al.

PLOS ONE (2020)

添加到收藏夹

Review Cell Biology

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

Jenny Sprooten et al.

CELLS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The role of necroptosis in cancer biology and therapy

Yitao Gong et al.

MOLECULAR CANCER (2019)

添加到收藏夹

Article Medicine, Research & Experimental

RBCK1 contributes to chemoresistance and sternness in colorectal cancer (CRC)

Min-Li Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

添加到收藏夹

Article Oncology

Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

Yiwei Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Oncology

Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis

Georgios D. Ayiomamitis et al.

CANCERS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

The Prognostic Importance of CD20+ B lymphocytes in Colorectal Cancer and the Relation to Other Immune Cell subsets

Sofia Edin et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Cell Biology

Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression

Kezhou Zhu et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van Hoecke et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Oncology

Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

Xian Li et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2017)

添加到收藏夹

Review Multidisciplinary Sciences

Natural products to prevent drug resistance in cancer chemotherapy: a review

Renyikun Yuan et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing

Abhishek D. Garg et al.

CELL DEATH AND DIFFERENTIATION (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer therapy in the necroptosis era

Z. Su et al.

CELL DEATH AND DIFFERENTIATION (2016)

添加到收藏夹

Article Oncology

Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis

Dominique Bozec et al.

ONCOTARGET (2016)

添加到收藏夹

Article Cell Biology

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

Gi-Bang Koo et al.

CELL RESEARCH (2015)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Th17 Cell Plasticity and Functions in Cancer Immunity

Leslie Guery et al.

BIOMED RESEARCH INTERNATIONAL (2015)

添加到收藏夹

Article Oncology

Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer

X. Feng et al.

NEOPLASMA (2015)

添加到收藏夹

Article Cell Biology

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Zhenyu Cai et al.

NATURE CELL BIOLOGY (2014)

添加到收藏夹

Review Medicine, General & Internal

Necroptosis

Andreas Linkermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Dendritic cell defects in the colorectal cancer

Annalisa Legitimo et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

添加到收藏夹

Article Immunology

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M. Murphy et al.

IMMUNITY (2013)

添加到收藏夹

Review Oncology

Cancer drug resistance: an evolving paradigm

Caitriona Holohan et al.

NATURE REVIEWS CANCER (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

添加到收藏夹

Article Cell Biology

Necroptosis as an alternative form of programmed cell death

Dana E. Christofferson et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

A Degterev et al.

NATURE CHEMICAL BIOLOGY (2005)

添加到收藏夹

Necroptosis-Related Genes Associated With Immune Activity and Prognosis of Colorectal Cancer

相关参考文献

导出引文

分享论文