MIR31HG Expression Predicts Poor Prognosis and Promotes Colorectal Cancer Progression

Review Cardiac & Cardiovascular Systems

MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics

Daniel Jakubik et al.

Summary: Research suggests that miRNAs and lncRNAs play a crucial role in the development of diabetic cardiomyopathy, serving as potential biomarkers for diagnosis, prognosis, and therapeutic strategies.

CARDIOVASCULAR DIABETOLOGY (2021)

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Review Oncology

Breast cancer liver metastasis: current and future treatment approaches

Narmeen S. Rashid et al.

Summary: Breast cancer liver metastasis (BCLM) is associated with poor prognoses, with therapeutic selection driven by histologic and molecular hallmarks. Pre-clinical studies are necessary to identify promising new treatment strategies, and accurate recapitulation of the disease process is critical. This review discusses the histologic and molecular characteristics of BCLM, evaluates existing treatment strategies, and suggests future preclinical study approaches.

CLINICAL & EXPERIMENTAL METASTASIS (2021)

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Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, Research & Experimental

PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1a

Jianlong Wang et al.

Summary: PCAT-1, a hypoxia-inducible lncRNA, regulates HIF-1a stability to promote breast cancer progression, suggesting its potential as a therapeutic target.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Biochemistry & Molecular Biology

Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a

Chengcai Lai et al.

Summary: The study identified a previously uncharacterized human lncRNA AVAN in patients infected with influenza A virus, which played a crucial role in antiviral immune responses by regulating the transcription of FOXO3a and enhancing TRIM25-mediated antiviral innate immune responses.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Medicine, Research & Experimental

Serum lncRNAs in early pregnancy as potential biomarkers for the prediction of pregnancy-induced hypertension, including preeclampsia

Chenguang Dai et al.

Summary: The study found that serum levels of certain lncRNAs were significantly increased in women with PIH compared to normotensive pregnant women. Seven candidate lncRNAs were correlated with the severity of PIH, and two lncRNAs were associated with adverse pregnancy outcomes. Nine pathways associated with these lncRNAs were confirmed to have associations with PIH.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Oncology

Long noncoding RNAs in cancer metastasis

S. John Liu et al.

Summary: Long noncoding RNAs play crucial roles in promoting metastasis by participating in discrete pro-metastatic steps and influencing the metastatic tumor microenvironment. They have the potential for diagnostic and therapeutic applications, but also face controversies and ongoing technical challenges. Further research is needed to explore their mechanisms and potential as targets for novel therapies in cancer metastasis.

NATURE REVIEWS CANCER (2021)

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Review Immunology

The inflammatory pathogenesis of colorectal cancer

Mark Schmitt et al.

Summary: The research on colorectal cancer indicates the importance of an inflammatory microenvironment for tumorigenesis, which influences the activation of immune cells and stromal cells, as well as the role of intestinal microbiome in tumor development. Chronic inflammation can initiate tumorigenesis, and tumor-elicited and therapy-induced inflammation are also implicated in promoting colorectal cancer.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology