4.6 Article

Design and Synthesis of Novel PRMT1 Inhibitors and Investigation of Their Effects on the Migration of Cancer Cell

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Protein Arginine Methyltransferases in Neuromuscular Function and Diseases

Jinwoo Lee et al.

Summary: Neuromuscular diseases are characterized by loss of muscle mass and strength, and there is currently no effective treatment. Protein arginine methyltransferases (PRMTs) are being investigated as potential therapeutic targets for these diseases.
Article Biochemistry & Molecular Biology

PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer

Xin-Ke Yin et al.

Summary: Arginine methylation, catalyzed by PRMTs, plays a crucial role in CRC. Overexpression of NONO in CRC tissue is associated with poor prognosis. Methylation of NONO by PRMT1 at R251 promotes CRC growth and metastasis, indicating PRMT1 inhibition as a potential therapeutic strategy for CRC treatment.

ONCOGENE (2021)

Article Oncology

Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells

Claudia Dominici et al.

Summary: The study finds that PARP inhibitors have a strong synergistic interaction with Type I PRMT inhibitors in NSCLC cells, significantly reducing cell viability. Re-introduction of MTAP decreases the sensitivity of the combination therapy in A549 cells, while the combination therapy leads to increased DNA damage and decreased cell viability. The combination therapy is also effective in PARPi resistant ovarian cancer cells, indicating the potential clinical impact of type I PRMT inhibitors in mitigating PARPi resistance.

CLINICAL EPIGENETICS (2021)

Article Biochemistry & Molecular Biology

PRMT1 promotes the tumor suppressor function of p14ARF and is indicative for pancreatic cancer prognosis

Antje Repenning et al.

Summary: The study reveals that PRMT1-mediated arginine methylation is crucial for triggering stress-induced tumor-suppressive function of p14(ARF). The interaction between PRMT1 and p14(ARF) leads to the release of p14(ARF) from nucleoli, promoting p53-independent apoptosis in response to genotoxic stress. This cooperation between PRMT1 and p14(ARF) has implications for cancer prognosis and chemotherapy response in pancreatic ductal adenocarcinoma.

EMBO JOURNAL (2021)

Article Genetics & Heredity

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

Bing Yao et al.

Summary: PRMT1-mediated H4R3me2a recruits SMARCA4, which promotes colorectal cancer progression by enhancing EGFR signaling.

GENOME MEDICINE (2021)

Article Biochemistry & Molecular Biology

The methyltransferase PRMT1 regulates γ-globin translation

Ying Wang et al.

Summary: Inducing fetal hemoglobin is an effective therapeutic strategy for overcoming adult beta-globin gene deficiency in treating beta-hemoglobinopathies. This study identified PRMT1 as a key regulator that can suppress gamma-globin synthesis specifically at the translational level, and this novel mechanism could be targeted by the PRMT1 inhibitor.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Biochemical Research Methods

Global analysis of protein arginine methylation

Fangrong Zhang et al.

Summary: Quantitative analysis of protein arginine methylation (ArgMet) using NMR spectroscopy revealed its prevalence and modulation by inhibitors and metabolites, providing insights into its role in health and disease.

CELL REPORTS METHODS (2021)

Article Medicine, Research & Experimental

PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma

Jianfeng Wang et al.

Summary: The study revealed that PRMT1 overexpression is associated with poor clinicopathological features and outcomes in clear cell renal cell carcinoma. PRMT1 promotes ccRCC cell growth by inducing G1 cell cycle arrest. LCN2 functions as a crucial downstream effector of PRMT1 in regulating ccRCC growth.

THERANOSTICS (2021)

Article Biochemistry & Molecular Biology

Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases

Kun Qian et al.

Summary: PRMTs are crucial epigenetic regulators involved in various human diseases, including cancer. Through virtual screening and enzymatic tests, a new potential anticancer inhibitor K313 was discovered, which exhibited significant inhibitory effects on cell proliferation in leukemia cells by targeting PRMT1.

RSC MEDICINAL CHEMISTRY (2021)

Article Oncology

PRMT1 promotes neuroblastoma cell survival through ATF5

Zhong-Yan Hua et al.

ONCOGENESIS (2020)

Review Medicine, General & Internal

Epithelial-Mesenchymal Transition in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Francesco Salton et al.

MEDICINA-LITHUANIA (2019)

Article Biochemistry & Molecular Biology

The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors

Yutong Sun et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Arginine methylation of SMAD7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem-cell generation

Yoko Katsuno et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Pathology

Epithelial Mesenchymal Transition in Tumor Metastasis

Vivek Mittal

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13 (2018)

Article Chemistry, Multidisciplinary

Mechanisms and Inhibitors of Histone Arginine Methylation

Melody D. Fulton et al.

CHEMICAL RECORD (2018)

Review Biochemistry & Molecular Biology

Arginine Methylation: The Coming of Age

Romeo S. Blanc et al.

MOLECULAR CELL (2017)

Article Chemistry, Medicinal

Design and synthesis of novel PRMT1 inhibitors and investigation of their binding preferences using molecular modelling

Hao Yang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Chemistry, Medicinal

Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1

Leilei Yan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Histone arginine methylation

Alessandra Di Lorenzo et al.

FEBS LETTERS (2011)

Article Chemistry, Medicinal

Target-based approach to inhibitors of histone arginine methyltransferases

Astrid Spannhoff et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Small molecule regulators of protein arginine methyltransferases

DH Cheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)