Improved comprehensive evaluation of Crohn?s disease activity by intestinal computed tomography enterography combined with endoscopy and biochemical indicators

Background and study aims: The treatment approach for Crohn's disease (CD) is focused on mucosal heal-ing and resolution of transmural inflammation. The aim of this study is to evaluate the correlation between computed tomography enterography (CTE) and other treatments, in particular, endoscopy and biochemical indicators, in newly diagnosed patients with CD. Patients and methods: One hundred twenty-three patients with CD who received CTE in Xiangya Hospital, Central South University, China, from April 2017 to April 2019 were included. The clinical case data and imaging results were retrospectively reviewed. The clinical activity of CD was determined by the Crohn's disease activity index (CDAI) score and biochemical indicators. The relationships between CTE and endo-scopy, CDAI score, and inflammatory markers were evaluated. Results: The diagnostic rate of CTE of the 123CD patients was 68.3% (84/123). Logistic regression analysis showed that the specific CTE manifestations related to CD activity were intestinal wall stratification, comb sign, and abdominal abscesses (P < 0.05). Spearman's rank correlation analysis showed that inflam-matory markers positively correlated with different CTE imaging manifestations. Conclusion: Intestinal CTE combined with endoscopy and biochemical indicators is both comprehensive and effective in evaluating the condition of CD patients. (c) 2022 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.

Automated summary

The aim of this study is to evaluate the correlation between computed tomography enterography (CTE) and other treatments, in particular, endoscopy and biochemical indicators, in newly diagnosed patients with Crohn's disease (CD). The diagnostic rate of CTE was 68.3%, and CTE was positively correlated with endoscopy and inflammatory markers. Intestinal CTE combined with endoscopy and biochemical indicators is comprehensive and effective in evaluating the condition of CD patients.