期刊
JOURNAL OF ORAL MICROBIOLOGY
卷 14, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/20002297.2022.2098644
关键词
Drug resistance; cell cycle; fibronectins; cell proliferation; proto-oncogene proteins c-fos
类别
资金
- National Natural Science Foundation of China [81870759, 81870778]
- Youth Grant of the Science and Technology, Department of Sichuan Province, China [2017JQ0028]
- Applied Basic Research Programs of Sichuan Province [2020YJ0227]
This study found that MRSA promotes the development of OSCC, and the FnBPA protein is a critical virulence factor. Targeting virulence factors can be a new method to block the interaction between drug-resistant pathogens and tumor development.
Background Oral squamous cell carcinoma (OSCC) is the most common tumor in the oral cavity. Methicillin-resistant Staphylococcus aureus (MRSA) were highly detected in OSCC patients; however, the interactions and mechanisms between drug-resistant bacteria (MRSA) and OSCC are not clear. Aim The aim of this study was to investigate the promotion of MRSA on the development of OSCC. Methods MRSA and MSSA (methicillin-susceptible) strains were employed to investigate the effect on the proliferation of OSCC in vitro and vivo. Results All of the MRSA strains significantly increased the proliferation of OSCC cells and MRSA arrested the cell cycles of OSCC cells in the S phase. MRSA activated the expression of TLR-4, NF-kappa B and c-fos in OSCC cells. MRSA also promoted the development of squamous cell carcinoma in vivo. The virulence factor fnbpA gene was significantly upregulated in all MRSA strains. By neutralizing FnBPA, the promotions of MRSA on OSCC cell proliferation and development of squamous cell carcinoma were significantly decreased. Meanwhile, the activation of c-fos and NF-kappa B by MRSA was also significantly decreased by FnBPA antibody. Conclusion MRSA promoted development of OSCC, and the FnBPA protein was the critical virulence factor. Targeting virulence factors is a new method to block the interaction between a drug-resistant pathogen and development of tumors.
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