Early Intracranial Hemorrhage Predicts Poor Clinical Outcome in Community-Acquired Bacterial Meningitis

BackgroundCommunity-acquired bacterial meningitis in adults is associated with significant morbidity and mortality; therefore, early prognostication is important to identify severe cases and possibly allocate more intensive treatment. We hypothesized that early intracranial hemorrhage portends a poor prognosis. The objective of this study was to evaluate the prognostic impact of early intracranial hemorrhage regardless of size and location on clinical outcome. MethodsRetrospective analysis of patients with community-acquired bacterial meningitis treated at a tertiary academic center between 2009 and 2019 about patient characteristics, cerebral imaging findings, and clinical outcome. Uni- and multivariable logistic regression analyses were performed to identify independent predictors of poor clinical outcomes defined as a modified Rankin scale score of 5 or 6 upon discharge. ResultsA total of 102 patients were included, of which 22.5% had poor clinical outcomes. Intracranial micro- or macrohemorrhages were present in 7.8% of cases and associated with poor clinical outcomes [odds ratio (OR) 55.75, 95% CI 3.08-1,008.48, p = 0.006] in multivariate analysis, further predictors included ischemic stroke (OR 15.06, 95% CI 1.32-172, p = 0.029), age (OR 2.56, 95% CI 1.4-4.67, p = 0.002), and reduced consciousness (OR 4.21, 95% CI 1.07-16.64, p = 0.04). ConclusionEarly cerebral hemorrhage (ECHO) is a potential prognostic marker for clinicians confronted with decision-making in patients who are critically ill with community-acquired bacterial meningitis.

Automated summary

This study retrospectively analyzed patients with community-acquired bacterial meningitis treated at a tertiary academic center between 2009 and 2019, evaluating the impact of early intracranial hemorrhage on clinical outcomes. The presence of intracranial micro- or macrohemorrhages was found to be significantly associated with poor clinical outcomes, suggesting that early cerebral hemorrhage can serve as a potential prognostic marker for clinicians managing critically ill patients with community-acquired bacterial meningitis.