期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.885672
关键词
monoclonal antibodies; antidrug antibodies; human leukocyte antigen; HLA haplotypes; ntADA; biomarker
类别
This review discusses ADA formation of mAbs and its clinical impact, as well as proposes the use of HLA haplotypes as biomarkers to predict patients' susceptibility to ADA formation.
The use of monoclonal antibodies (mAbs) in the clinic has successfully expanded to treatment of cancer, viral infections, inflammations, and other indications. However, some of the classes of mAbs that are used in the clinic show the formation of anti-drug antibodies (ADAs) leading to loss of efficacy. This review describes ADA formation for the various mAbs, and its clinical effect. Lastly, this review considers the use of HLA-haplotypes as biomarkers to predict vulnerability of patients sensitive to formation of ADAs.
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