DCBLD1 Overexpression Is Associated With a Poor Prognosis in Head and Neck Squamous Cell Carcinoma

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Radiotherapy and immunotherapy combination in head and neck cancer: Does current failure qualify as an ending or is it a key to future success?

Panagiota Economopoulou et al.

Summary: Radiation therapy is a main treatment modality for head and neck squamous cell carcinoma, inducing cell death through DNA damage. In addition to its direct effects on tumor cells, radiation also promotes antitumor immunity and immunogenic cell death.

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Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer

Yi Wang et al.

Summary: Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) or programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1)-based immune checkpoint inhibitors (ICIs) have shown significant improvements in overall survival of certain cancer patients, but resistance to immunotherapy remains a challenge. This article examines the metabolic modulation of tumor immunity and immune checkpoints in the tumor microenvironment (TME) and discusses potential metabolism-based therapeutic strategies. Understanding the link between tumor metabolism and immunotherapy is crucial for cancer treatment and research.

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CMTM6 and PD-1/PD-L1 overexpression is associated with the clinical characteristics of malignancy in oral squamous cell carcinoma

Songtao Zhang et al.

Summary: The study showed that the expression of CMTM6 and PD-1/PD-L1 was significantly higher in OSCC tissues compared to paracancerous tissues. PD-L1 expression was associated with clinical stage and lymph node metastasis in OSCC. qRT-PCR results confirmed the relationship between mRNA and protein expression.

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Prognostic Significance of CD4+and CD8+Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis

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Summary: This study provides evidence for the prognostic significance of CD8+ and CD4+ TILs in HNSCC, with variations in tumor subsite needing further investigation. TILs may serve as predictive biomarkers for risk stratifying patients and further research is needed in the application of immune-checkpoint inhibitors.

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High Expression of Hyaluronan-Mediated Motility Receptor Predicts Adverse Outcomes: A Potential Therapeutic Target for Head and Neck Squamous Cell Carcinoma

Tianzhu Lu et al.

Summary: The study found that HMMR is highly expressed in HNSCC tumor tissue, and high HMMR mRNA expression is an independent prognostic factor in TCGA and GSE41613 data. The methylation level of HMMR is negatively correlated with its expression, with patients having low methylation levels showing worse overall survival. HMMR may be associated with biological functions related to the KARS, EMT, and G2M checkpoint pathways, interferon-gamma, and interferon-alpha responses.

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Maternally expressed 3 inhibits the biological activity of oral squamous cell carcinoma SCC25 and CAL27 cell lines

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DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma

Guillaume B. Cardin et al.

Summary: Germline single nucleotide polymorphisms in the promoter region of the DCBLD1 gene are associated with non-smoking cases of both non-small cell lung carcinoma (NSCLC) and human papillomavirus-negative head and neck cancer, with high DCBLD1 expression linked to worse overall survival. Patients with high DCBLD1 expression show an upregulation of the integrin signaling pathway.

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High SEC61G expression predicts poor prognosis in patients with Head and Neck Squamous Cell Carcinomas

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Single Nucleotide Polymorphism rs6942067 Is a Risk Factor in Young and in Non-Smoking Patients with HPV Negative Head and Neck Squamous Cell Carcinoma

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SNP rs17079281 decreases lung cancer risk through creating an YY1-binding site to suppress DCBLD1 expression

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Dynamic multi-site phosphorylation by Fyn and Abl drives the interaction between CRKL and the novel scaffolding receptors DCBLD1 and DCBLD2

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DCBLD1 Overexpression Is Associated With a Poor Prognosis in Head and Neck Squamous Cell Carcinoma

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