Immunosenescence, aging and successful aging

Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and successful aging, and the effects on diseases are not revealed obviously. In order to provide theoretical basis for preventing or controlling diseases effectively and achieve successful aging, we conducted the review and found that changes of aging-related phenotypes, deterioration of immune organ function and alterations of immune cell subsets participated in the process of immunosenescence, which had great effects on the occurrence and development of age-related diseases.

Automated summary

Immunosenescence, the immune related changes caused by aging, plays crucial roles in various age-related diseases, including neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases, and COVID-19. However, the mechanisms, association with aging and successful aging, as well as the effects on diseases, are not clearly understood. This review highlights the involvement of aging-related phenotypic changes, deterioration of immune organ function, and alterations of immune cell subsets in the process of immunosenescence, which significantly impact the occurrence and development of age-related diseases.