Advances in understanding interferon-mediated immune responses to enteric viruses in intestinal organoids

Article Biology

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

Jacob A. Van Winkle et al.

Summary: Bacterial microbiota stimulate the expression of antiviral genes in intestinal epithelial cells, enhancing host defense against enteric viruses.

ELIFE (2022)

添加到收藏夹

Article Cell Biology

Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota

Sanghyun Lee et al.

Summary: Mutations in the autophagy gene EPG5 lead to protection against multiple enteric viruses in mice, primarily through modulation of intestinal IFNλ responses, independent of microbiota influence.

AUTOPHAGY (2022)

添加到收藏夹

Article Virology

Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial Cells

Camila Metz-Zumaran et al.

Summary: This study demonstrates that both type I and III interferons can inhibit SARS-CoV-2 infection in human intestinal cells, but type III interferons exhibit stronger antiviral activity. Shorter treatment times and lower concentrations are required for type III interferons to effectively reduce virus load. Furthermore, type III interferons can significantly inhibit SARS-CoV-2 even 4 hours post-infection and induce a long-lasting antiviral effect in intestinal epithelial cells.

JOURNAL OF VIROLOGY (2022)

添加到收藏夹

Review Microbiology

SARS-CoV-2 pathogenesis

Mart M. Lamers et al.

Summary: This Review explores the recent clinical and experimental advancements in understanding the pathogenesis of SARS-CoV-2, its interactions with host cells, and the role of the immune system in the development of severe disease, with a focus on the mechanisms underlying COVID-19-associated ARDS. The findings suggest that SARS-CoV-2 can infect the lower respiratory tract, causing alveolar damage and dysfunctional immune responses, leading to inflammation and immunopathology. These insights may contribute to the development of new therapeutic interventions against COVID-19.

NATURE REVIEWS MICROBIOLOGY (2022)

添加到收藏夹

Article Microbiology

Human Norovirus Triggers Primary B Cell Immune Activation In Vitro

Carmen Mirabelli et al.

Summary: Research found that primary B cells are susceptible to HNoV infection and the NS1 protein can alter B cell activation and metabolism, suggesting important implications for viral pathogenesis and immune responses.

MBIO (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ins and Outs of Reovirus: Vesicular Trafficking in Viral Entry and Egress

Alexa N. Roth et al.

Summary: The function of intracellular vesicular transport systems in reovirus entry, trafficking, and egress is discussed, with a focus on designing strategic therapeutic interventions. Understanding the mechanisms by which viruses coopt vesicular trafficking may lead to the development of antiviral agents.

TRENDS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Virology

Targeted Profiling of Immunological Genes during Norovirus Replication in Human Intestinal Enteroids

Jenny C. M. Chan et al.

Summary: Norovirus is the major cause of acute gastroenteritis worldwide but its pathogenesis and immune response are still unclear due to the lack of a robust virus culture system. In this study, productive norovirus replications were achieved in 75% of inoculations using secretor-positive Chinese human intestinal enteroid (HIE) lines. The upregulation of immune-related genes CXCL10 and IFI44L was positively correlated with norovirus RNA replication levels, suggesting HIE as a potential model for future virus-host interaction studies.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Microbiology

New Insights and Enhanced Human Norovirus Cultivation in Human Intestinal Enteroids

Khalil Ettayebi et al.

Summary: The study demonstrates that optimization of cultivation conditions in human intestinal enteroid cultures can effectively replicate multiple strains of human noroviruses (HuNoVs), which is crucial for research on HuNoV biology and the development of treatment methods.

MSPHERE (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Interferon responses to norovirus infections: current and future perspectives

Aminu S. Jahun et al.

Summary: Human noroviruses are a major cause of transmissible gastroenteritis globally, with no effective treatment or vaccine available. Understanding host responses to infection and the importance of IFN responses in restricting noroviruses is critical for the development of vaccines or treatments. This review discusses the molecular mechanisms of IFN induction in norovirus-infected cells and the strategies used by noroviruses to evade host IFN responses.

JOURNAL OF GENERAL VIROLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses

Jessica Oi-Ling Tsang et al.

Summary: The human small intestinal organoids have been established as a novel platform for characterizing viral replication kinetics and evaluating candidate antivirals for enteroviruses, showing promising results for studying pathogenesis and antiviral drug development.

BIOMEDICINES (2021)

添加到收藏夹

Review Biochemical Research Methods

Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases

Julia Y. Co et al.

Summary: The polarity of gastrointestinal organoids is reversed to study epithelial biology and host-microbe interactions, allowing increased access to the apical surface while preserving functions. The method quickly establishes an outward-facing apical surface, maintaining epithelial integrity, secretory and absorptive functions, and enabling differentiation control. This technique enhances the possibilities of organoid use in gastrointestinal and respiratory health and disease research by controlling organoid polarity.

NATURE PROTOCOLS (2021)

添加到收藏夹

Article Immunology

Murine astrovirus tropism for goblet cells and enterocytes facilitates an IFN-λ response in vivo and in enteroid cultures

Harshad Ingle et al.

Summary: Astroviruses, which cause viral gastroenteritis in children globally, have been understudied due to the lack of well-defined animal models. This study establishes a platform to cultivate muAstV using mouse enteroid-derived air-liquid interface (ALI) cultures, providing insights into chronic infection characteristics and the correlation with interferon-lambda expression in the small intestine.

MUCOSAL IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Differential roles of interferons in innate responses to mucosal viral infections

Forrest C. Walker et al.

Summary: Interferons play specific roles in limiting local and systemic infection, showing synergistic activities and a spectrum of protective and detrimental effects during the infection response.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut

Sergio Triana et al.

Summary: An exacerbated pro-inflammatory immune response contributes to COVID-19 pathology, with the gut identified as a prime target of SARS-CoV-2 infection. Infected cells activate strong pro-inflammatory programs and produce interferon, while expression of interferon-stimulated genes is limited to bystander cells.

MOLECULAR SYSTEMS BIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection

Sergio Triana et al.

Summary: The study revealed that interferon controls human astrovirus infection and the virus can infect all major cell types and lineages in human intestinal organoids. Each intestinal epithelial cell lineage undergoes an antiviral transcriptional reprogramming by upregulating distinct sets of interferon-stimulated genes upon infection, indicating a unique role in resolving virus infection.

MOLECULAR SYSTEMS BIOLOGY (2021)

添加到收藏夹

Article Virology

Comparative Analysis of Public RNA-Sequencing Data from Human Intestinal Enteroid (HIEs) Infected with Enteric RNA Viruses Identifies Universal and Virus-Specific Epithelial Responses

Roberto J. Cieza et al.

Summary: Recent studies utilizing novel biomimetic human models of enteric disease have identified conserved and specific epithelial responses to viral infections in acute gastroenteritis (AGE), shedding light on host-microbe interactions at the intestinal epithelial interface.

VIRUSES-BASEL (2021)

添加到收藏夹

Review Virology

Experimental Methods to Study the Pathogenesis of Human Enteric RNA Viruses

Somya Aggarwal et al.

Summary: This article discusses the methodological advancements and tools available for studying human enteric RNA viruses, including in vitro and in vivo experiments. It provides insights into many features of viral pathogenesis and unclear aspects, highlighting key areas and opportunities that require further research.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Biology

Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates

Megan Culler Freeman et al.

Summary: EV-D68 virus is associated with severe respiratory illness and acute flaccid myelitis, potentially transmitted through respiratory and enteric routes. Recent isolates show decreased sensitivity to acid and temperature, with respiratory epithelium inducing a robust defense response to restrict infection.

ELIFE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

Yuling Han et al.

Summary: Researchers have developed lung and colonic organoid models using human pluripotent stem cells, which demonstrate susceptibility to SARS-CoV-2 infection. These models are valuable for studying the infection of the virus and screening drugs, with potential therapeutic implications for COVID-19.

NATURE (2021)

添加到收藏夹

Article Immunology

Comparison of Microneutralization and Histo-Blood Group Antigen-Blocking Assays for Functional Norovirus Antibody Detection

Robert L. Atmar et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Microbiology

Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells

Megan L. Stanifer et al.

NATURE MICROBIOLOGY (2020)

添加到收藏夹

Article Cell Biology

A brief history of organoids

Claudia Corro et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Covid-19 and the digestive system

Sunny H. Wong et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 productively infects human gut enterocytes

Mart M. Lamers et al.

SCIENCE (2020)

添加到收藏夹

Article Microbiology

Norovirus Replication in Human Intestinal Epithelial Cells Is Restricted by the Interferon-Induced JAK/STAT Signaling Pathway and RNA Polymerase II-Mediated Transcriptional Responses

Myra Hosmillo et al.

mBio (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Human norovirus targets enteroendocrine epithelial cells in the small intestine

Kim Y. Green et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Infection of bat and human intestinal organoids by SARS-CoV-2

Zhou Jie et al.

NATURE MEDICINE (2020)

添加到收藏夹

Letter Gastroenterology & Hepatology

Prolonged presence of SARS-CoV-2 viral RNA in faecal samples

Yongjian Wu et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

添加到收藏夹

Article Immunology

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

Ruochen Zang et al.

SCIENCE IMMUNOLOGY (2020)

添加到收藏夹

Review Infectious Diseases

Pediatric acute gastroenteritis associated with adenovirus 40/41 in low-income and middle-income countries

Benjamin Lee et al.

CURRENT OPINION IN INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Cell Biology

Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions

Kim E. Boonekamp et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Article Cell Biology

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

Megan L. Stanifer et al.

CELL REPORTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids

Shih-Ching Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Microbiology

Rotavirus Infection and Cytopathogenesis in Human Biliary Organoids Potentially Recapitulate Biliary Atresia Development

Sunrui Chen et al.

MBIO (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Human sapovirus propagation in human cell lines supplemented with bile acids

Hirotaka Takagi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Cell Biology

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

Julia Y. Co et al.

CELL REPORTS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Type III interferon signaling restricts enterovirus 71 infection of goblet cells

Charles Good et al.

SCIENCE ADVANCES (2019)

添加到收藏夹

Article Microbiology

Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ

Harshad Ingle et al.

NATURE MICROBIOLOGY (2019)

添加到收藏夹

Article Microbiology

IFN-I and IL-22 mediate protective effects of intestinal viral infection

Jessica A. Neil et al.

NATURE MICROBIOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Adenovirus persistence, reactivation, and clinical management

Thomas Lion

FEBS LETTERS (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Updated classification of norovirus genogroups and genotypes

Preeti Chhabra et al.

JOURNAL OF GENERAL VIROLOGY (2019)

添加到收藏夹

Article Microbiology

Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape

Abimbola O. Kolawole et al.

PLOS PATHOGENS (2019)

添加到收藏夹

Review Infectious Diseases

Astrovirus evolution and emergence

Nicholas Wohlgemuth et al.

INFECTION GENETICS AND EVOLUTION (2019)

添加到收藏夹

Article Virology

Genetic diversity of human sapovirus across the Americas

Marta Diez-Valcarce et al.

JOURNAL OF CLINICAL VIROLOGY (2018)

添加到收藏夹

Article Virology

Adenovirus Infection of Human Enteroids Reveals Interferon Sensitivity and Preferential Infection of Goblet Cells

Mayumi K. Holly et al.

JOURNAL OF VIROLOGY (2018)

添加到收藏夹

Review Medicine, General & Internal

Viral gastroenteritis

Krisztian Banyai et al.

LANCET (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Attempts to grow human noroviruses, a sapovirus, and a bovine norovirus in vitro

Tomoichiro Oka et al.

PLOS ONE (2018)

添加到收藏夹

Review Virology

Distinct Effects of Type I and III Interferons on Enteric Viruses

Harshad Ingle et al.

VIRUSES-BASEL (2018)

添加到收藏夹

Article Multidisciplinary Sciences

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

Siyuan Ding et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Cell & Tissue Engineering

JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation

Camilla A. Richmond et al.

STEM CELL REPORTS (2018)

添加到收藏夹

Article Virology

HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection

Donna A. MacDuff et al.

JOURNAL OF VIROLOGY (2018)

添加到收藏夹

Article Infectious Diseases

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

Christopher Troeger et al.

LANCET INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Microbiology

A viral trigger for celiac disease

Judy J. Brown et al.

PLOS PATHOGENS (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses

Gabriela Alvarado et al.

GASTROENTEROLOGY (2018)

添加到收藏夹

Article Public, Environmental & Occupational Health

Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study

James A. Platts-Mills et al.

LANCET GLOBAL HEALTH (2018)

添加到收藏夹

Article Immunology

Human Norovirus Replication in Human Intestinal Enteroids as Model to Evaluate Virus Inactivation

Veronica Costantini et al.

EMERGING INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

Shu Zhu et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

Kapil Saxena et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner

Coyne G. Drummond et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

Romain Bouziat et al.

SCIENCE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Circulation of HAdV-41 with diverse genome types and recombination in acute gastroenteritis among children in Shanghai

Peng Li et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Virology

Astrovirus Biology and Pathogenesis

Valerie Cortez et al.

ANNUAL REVIEW OF VIROLOGY, VOL 4 (2017)

添加到收藏夹

Review Immunology

Interferon Lambda Genetics and Biology in Regulation of Viral Control

Emily A. Hemann et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut

Kalliopi Pervolaraki et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹

Review Gastroenterology & Hepatology

Gastrointestinal Organoids: Understanding the Molecular Basis of the Host-Microbe Interface

David R. Hill et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

Nicholas C. Zachos et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

添加到收藏夹

Article Virology

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology

Kapil Saxena et al.

JOURNAL OF VIROLOGY (2016)

添加到收藏夹

Article Immunology

Norovirus Infections Occur in B-Cell-Deficient Patients

Julianne R. Brown et al.

CLINICAL INFECTIOUS DISEASES (2016)

添加到收藏夹

Article Infectious Diseases

Persistence and reactivation of human adenoviruses in the gastrointestinal tract

K. Kosulin et al.

CLINICAL MICROBIOLOGY AND INFECTION (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients

Umesh C. Karandikar et al.

JOURNAL OF GENERAL VIROLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Replication of human noroviruses in stem cell-derived human enteroids

Khalil Ettayebi et al.

SCIENCE (2016)

添加到收藏夹

Article Microbiology

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

Siyuan Ding et al.

PLOS PATHOGENS (2016)

添加到收藏夹

Article Microbiology

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity

Timothy J. Nice et al.

PLOS PATHOGENS (2016)

添加到收藏夹

Article Microbiology

Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections

Jian-Da Lin et al.

PLOS PATHOGENS (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Modeling rotavirus infection and antiviral therapy using primary intestinal organoids

Yuebang Yin et al.

ANTIVIRAL RESEARCH (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

Sina Bartfeld et al.

GASTROENTEROLOGY (2015)

添加到收藏夹

Article Immunology

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

Pedro P. Hernandez et al.

NATURE IMMUNOLOGY (2015)

添加到收藏夹

Article Biochemical Research Methods

Human norovirus culture in B cells

Melissa K. Jones et al.

NATURE PROTOCOLS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori

Sina Bartfeld et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity

Timothy J. Nice et al.

SCIENCE (2015)

添加到收藏夹

Review Microbiology

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

Thomas Lion

CLINICAL MICROBIOLOGY REVIEWS (2014)

添加到收藏夹

Review Microbiology

Human Astroviruses

Albert Bosch et al.

CLINICAL MICROBIOLOGY REVIEWS (2014)

添加到收藏夹

Article Microbiology

Genotypic and Epidemiologic Trends of Norovirus Outbreaks in the United States, 2009 to 2013

Everardo Vega et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Enteric bacteria promote human and mouse norovirus infection of B cells

Melissa K. Jones et al.

SCIENCE (2014)

添加到收藏夹

Article Immunology

Norovirus Epidemiology in Community and Health Care Settings and Association with Patient Age, Denmark

Kristina T. Franck et al.

EMERGING INFECTIOUS DISEASES (2014)

添加到收藏夹

Article Virology

Adaptive Immunity Restricts Replication of Novel Murine Astroviruses

Christine C. Yokoyama et al.

JOURNAL OF VIROLOGY (2012)

添加到收藏夹

Article Microbiology

Rotavirus Stimulates Release of Serotonin (5-HT) from Human Enterochromaffin Cells and Activates Brain Structures Involved in Nausea and Vomiting

Marie Hagbom et al.

PLOS PATHOGENS (2011)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Enhancement of Enteric Adenovirus Cultivation by Viral Transactivator Proteins

Misoon Kim et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)

添加到收藏夹

Article Oncology

Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation

T. Lion et al.

LEUKEMIA (2010)

添加到收藏夹

Article Virology

Human stool contains a previously unrecognized diversity of novel astroviruses

Stacy R. Finkbeiner et al.

VIROLOGY JOURNAL (2009)

添加到收藏夹

Article Microbiology

Rotavirus NSP1 Inhibits NF kappa B Activation by Inducing Proteasome-Dependent Degradation of beta-TrCP: A Novel Mechanism of IFN Antagonism

Joel W. Graff et al.

PLOS PATHOGENS (2009)

添加到收藏夹

Article Virology

Human astrovirus isolation and propagation in multiple cell lines

JP Brinker et al.

ARCHIVES OF VIROLOGY (2000)

添加到收藏夹

Advances in understanding interferon-mediated immune responses to enteric viruses in intestinal organoids

相关参考文献

导出引文

分享论文