期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.916411
关键词
Treg; FOXP3; COVID-19; SARS-CoV-2; Treg-based therapy
类别
资金
- National Key Research and Development Program of China [2019YFA09006100]
- National Natural Science Founding of China [32130041, 81830051, 31961133011]
- Innovative research team of high-level local universities in Shanghai and Shanghai Collaborative Innovation Center of Cellular Homeostasis Regulation and Human Diseases
- Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases
- Shanghai Jiao Tong University (SJTU) - The Chinese University of Hong Kong (CUHK) Joint Research Collaboration Fund
- Fundamental Research Funds for Central Universities
The COVID-19 pandemic has caused severe global impact, with activated immune response as a key feature. Regulatory T cells play a crucial role in suppressing inflammatory response and tissue repair. Research on the changes of FOXP3(+) Tregs in COVID-19 patients, their relationship with disease severity, and the potential role of FOXP3(+) Tregs in SARS-CoV-2 infection are discussed.
Coronavirus disease 2019 (COVID-19) has been raging all around the world since the beginning of 2020, and leads to acute respiratory distress syndrome (ARDS) with strong cytokine storm which contributes to widespread tissue damage and even death in severe patients. Over-activated immune response becomes one of the characteristics of severe COVID-19 patients. Regulatory T cells (Treg) play an essential role in maintaining the immune homeostasis, which restrain excessive inflammation response. So FOXP3(+) Tregs might participate in the suppression of inflammation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Besides suppressive function, tissue resident Tregs are also responsible for tissue repair. In this review, we mainly summarize the latest research focusing on the change of FOXP3(+) Tregs in the COVID-19 patients, discuss the relationship between disease severity and number change of Tregs and speculate the potential role of FOXP3(+) Tregs during SARS-CoV-2 infection. Furthermore, we introduce some potential Treg-based therapies to improve patients' outcomes, which include small molecular drugs, antibody drugs, CAR-Treg and cytokine treatment. We hope to reduce tissue damage of severe COVID-19 patients and offer better prognosis through Treg-based therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据