期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.819574
关键词
gamma delta (gamma delta) T cells; SARS-CoV-2; innate immunity; aminobisphosphonates COVID-19; COVID-19
类别
资金
- NIH
- [R01-AI125097]
- [R21-AI157864]
COVID-19 is a complex disease caused by SARS-CoV-2, and the immune response to the disease can vary. The role of gamma delta T cells in COVID-19 has not been extensively studied, but they may contribute to the control of infection in mild to moderate clinical outcomes.
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a complex disease which immune response can be more or less potent. In severe cases, patients might experience a cytokine storm that compromises their vital functions and impedes clearance of the infection. Gamma delta (gamma delta) T lymphocytes have a critical role initiating innate immunity and shaping adaptive immune responses, and they are recognized for their contribution to tumor surveillance, fighting infectious diseases, and autoimmunity. gamma delta T cells exist as both circulating T lymphocytes and as resident cells in different mucosal tissues, including the lungs and their critical role in other respiratory viral infections has been demonstrated. In the context of SARS-CoV-2 infection, gamma delta T cell responses are understudied. This review summarizes the findings on the antiviral role of gamma delta T cells in COVID-19, providing insight into how they may contribute to the control of infection in the mild/moderate clinical outcome.
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