Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

Article Cardiac & Cardiovascular Systems

Association of cardiometabolic microRNAs with COVID-19 severity and mortality

Clemens Gutmann et al.

Summary: Research shows that circulating miRNAs from different tissue origins play a crucial role in the severity and prognosis of COVID-19, with miR-133a and miR-122 potentially associated with the risk of mortality in patients.

CARDIOVASCULAR RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Deregulated Expression of miR-483-3p Serves as a Diagnostic Biomarker in Severe Pneumonia Children with Respiratory Failure and Its Predictive Value for the Clinical Outcome of Patients

Juan Zhou et al.

Summary: This study revealed that the expression of serum miR-483-3p was higher in children with severe pneumonia compared to controls, and it had diagnostic value for severe pneumonia. High expression of miR-483-3p promoted the development of severe pneumonia by inhibiting cell proliferation, promoting cell apoptosis, and increasing the production of inflammatory cytokines.

MOLECULAR BIOTECHNOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium

Diana A. Gorog et al.

Summary: COVID-19 predisposes patients to thrombotic and thromboembolic events. Numerous biomarkers have emerged to assess the thrombotic risk in these patients, informing prognosis and predicting thrombosis.

NATURE REVIEWS CARDIOLOGY (2022)

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Review Virology

miRNAs, from Evolutionary Junk to Possible Prognostic Markers and Therapeutic Targets in COVID-19

Brandon Bautista-Becerril et al.

Summary: The COVID-19 pandemic has highlighted the importance of prognostic predictors and therapeutic targets in the disease. miRNA biomolecules have been shown to play a vital role in regulating genes associated with the pathophysiology of COVID-19 and can be used as predictors of complications and potential targets for treatment. However, further studies are needed to confirm these findings.

VIRUSES-BASEL (2022)

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Article Multidisciplinary Sciences

Cell specific peripheral immune responses predict survival in critical COVID-19 patients

Junedh M. Amrute et al.

Summary: In this study, single-cell sequencing and machine learning were used to characterize the immune response in critically ill COVID-19 patients. The researchers found cell type-specific transcriptional signatures that are associated with and can predict survival in these patients. The activation of antibody processing, early activation response, and cell cycle regulation pathways were most prominent in patients who survived the infection. Furthermore, interferon signaling and antigen presentation pathways within specific immune cell types were identified as predictors of mortality with high accuracy.

NATURE COMMUNICATIONS (2022)

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Article Immunology

Plasma miRNA profile at COVID-19 onset predicts severity status and mortality

Asier Fernandez-Pato et al.

Summary: COVID-19 deeply affects the plasma miRNome from an early stage, indicating that miRNAs can serve as valuable early predictors of severity and mortality.

EMERGING MICROBES & INFECTIONS (2022)

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Article Immunology

A Differential Signature of Circulating miRNAs and Cytokines Between COVID-19 and Community-Acquired Pneumonia Uncovers Novel Physiopathological Mechanisms of COVID-19

Pedro Martinez-Fleta et al.

Summary: This study compared plasma miRNA and cytokine profiles between COVID-19 and other community-acquired pneumonias (CAP), revealing 15 dysregulated miRNAs and differential cytokine signatures. These findings provide new insights into the etiopathological mechanisms of COVID-19.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19

Julie C. Wilson et al.

Summary: This study found that inflammatory cytokines and chemokines play an important role in the pathogenesis of COVID-19. By analyzing the measurements of microRNA and CC, it is possible to more accurately distinguish patients with severe disease. Furthermore, the analysis of an independent cohort confirmed the feasibility of CC/miRNA profiling in clinical practice and identified key factors associated with fatal COVID-19.

ISCIENCE (2022)

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Article Health Care Sciences & Services

miR-155: A Potential Biomarker for Predicting Mortality in COVID-19 Patients

Reut Kassif-Lerner et al.

Summary: This study investigated circulating miRNAs in hospitalized COVID-19 patients and found that miR-155 expression was lower in mild and severe patients compared to healthy individuals. The researchers also identified miR-155 as a good predictor of COVID-19 mortality and suggested testing miR-155 levels upon admission to improve patient care.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article Biology

microRNAs and Inflammatory Immune Response in SARS-CoV-2 Infection: A Narrative Review

Beatrice Maranini et al.

Summary: In this review, the role of ncRNAs in the immune system crosstalk during SARS-CoV-2 infection, specifically focusing on inflammatory pathways and cytokine storm syndromes, is discussed. The study aims to investigate the interaction between SARS-CoV-2 and the host, exploring the potential of miRNA-based therapeutics in tackling SARS-CoV-2 complications.

LIFE-BASEL (2022)

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Article Cell Biology

Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality

Angelica Giuliani et al.

Summary: This study aimed to identify circulating miRNAs associated with the risk of in-hospital mortality in COVID-19 patients. Serum samples of 12 COVID-19 patients were analyzed and the findings were validated in a separate cohort. The study identified significantly elevated levels of miR-320b and miR-483-5p in deceased patients compared to survivors.

MECHANISMS OF AGEING AND DEVELOPMENT (2022)

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Article Multidisciplinary Sciences

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Caroline Junqueira et al.

Summary: This study suggests that SARS-CoV-2 infection in monocytes and macrophages, mediated by antibody uptake, triggers inflammatory cell death and systemic inflammation, which prevents the production of infectious virus but contributes to COVID-19 pathogenesis.

NATURE (2022)

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Article Microbiology

Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology

Lucia Morales et al.

Summary: The SARS-CoV-2 pandemic has emphasized the need to understand the mechanisms of severe lung inflammatory pathology caused by human deadly coronaviruses in order to design new antiviral therapies. Here, we identify miRNA-223-3p as a host miRNA involved in the regulation of lung inflammatory response mediated by envelope (E) protein during SARS-CoV infection. This finding is significant for the development of new antiviral therapies.

MBIO (2022)

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Article Multidisciplinary Sciences

Circulating microRNA profiling is altered in the acute respiratory distress syndrome related to SARS-CoV-2 infection

Natalia Garcia-Giralt et al.

Summary: One of the hallmarks of SARS-CoV-2 infection is immune dysregulation, leading to cytokine storm syndrome and acute respiratory distress syndrome (ARDS). This study found that the circulating miRNA, miR-369-3p, was significantly decreased in COVID-19 patients requiring mechanical ventilation, suggesting its potential as a prognostic factor for ARDS.

SCIENTIFIC REPORTS (2022)

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Article Medicine, General & Internal

Cardiovascular signatures of COVID-19 predict mortality and identify barrier stabilizing therapies

Dakota Gustafson et al.

Summary: This study prospectively evaluated circulating inflammatory, cardiac, and endothelial cell activation markers in COVID-19 patients and identified microRNA and vascular biomarkers that are prognostic of in-hospital mortality. The study also found that COVID-19 patient plasma can cause endothelial barrier dysfunction, which can be improved with therapeutic interventions.

EBIOMEDICINE (2022)

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Article Medicine, Research & Experimental

Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis

Wojciech Francuzik et al.

Summary: This study aimed to investigate serum biomarker profiles (proteins, lipids, and miRNAs) to support the diagnosis of anaphylaxis. It was found that hsa-miR-451a was elevated during anaphylaxis and could serve as a significant biomarker. Additionally, combining multiple biomarkers improved the accuracy of diagnosing patients with anaphylaxis.

JCI INSIGHT (2022)

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Article Multidisciplinary Sciences

Distinct miRNAs associated with various clinical presentations of SARS-CoV-2 infection

Qiqi Zeng et al.

iScience (2022)

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Article Immunology

Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses - are we our own worst enemy?

Lok-Yin Roy Wong et al.

Summary: Human coronaviruses can cause a wide range of diseases, with severe cases characterized by dysregulated host immune responses and active viral interference. The severity of disease is mainly determined by host immune responses and viral interference.

NATURE REVIEWS IMMUNOLOGY (2022)

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Article Biochemical Research Methods

IsoMiRmap: fast, deterministic and exhaustive mining of isomiRs from short RNA-seq datasets

Phillipe Loher et al.

Summary: IsomiRs, the multiple isoforms generated from microRNA precursors, are influenced by factors such as sex, genetic ancestry, and tissue type. IsoMiRmap is a fast, standalone, user-friendly tool that accurately identifies and quantifies all isomiRs while providing comprehensive information.

BIOINFORMATICS (2021)

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Article Critical Care Medicine

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study

Rishi K. Gupta et al.

Summary: A prognostic model was developed and validated to predict the risk of clinical deterioration in acute COVID-19 cases. The model showed consistent discrimination, calibration, and clinical utility across different regions, demonstrating strong potential for informing decision making among hospitalized adults with COVID-19.

LANCET RESPIRATORY MEDICINE (2021)

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Article Medicine, Research & Experimental

An immune-based biomarker signature is associated with mortality in COVID-19 patients

Michael S. Abers et al.

Summary: Immune and inflammatory responses are important factors contributing to disease severity in COVID-19. This study identified specific immune-based biomarkers associated with mortality in COVID-19 patients, with some biomarkers consistently higher in those who died compared to those who recovered, suggesting their potential for early prediction of disease outcome.

JCI INSIGHT (2021)

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Letter Immunology

Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients

Penghui Yang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

MicroRNA-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload

Deepak Ramanujam et al.

Summary: Recent research has shown that miR-21 is the most highly expressed microRNA in cardiac macrophages, playing a critical role in fibrosis and cardiac dysfunction. Furthermore, miR-21 regulates the polarization of macrophages towards an M1-like phenotype and promotes communication between macrophages and cardiac fibroblasts, leading to fibrotic remodeling.

CIRCULATION (2021)

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Article Biochemistry & Molecular Biology

The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p

Dong-Liang Chen et al.

Summary: The study highlights the upregulation of circDLG1 in distant metastatic lesions and gastric cancer tissues resistant to anti-PD-1 therapy, correlating with aggressive tumor phenotype and poor prognosis. Ectopic circDLG1 expression promotes proliferation, migration, invasion, and immune evasion of gastric cancer cells. Mechanistically, circDLG1 interacts with miR-141-3p as a miRNA sponge to increase CXCL12 expression, promoting gastric cancer progression and resistance to anti-PD-1 therapy.

MOLECULAR CANCER (2021)

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Review Biochemistry & Molecular Biology

SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids

Marta Trevisan et al.

Summary: This Review briefly describes the virology and pathogenesis of SARS-CoV-2, emphasizing how stem cell technology and organoids can help understand the cell tropisms of SARS-CoV-2 and its disease mechanisms in the human host. Studies using these technologies showed that lung epithelial cells, gastrointestinal cells, heart cells, and choroid plexus epithelial cells are key targets of SARS-CoV-2, leading to cell damage and inflammation. Neurological symptoms and vascular damage are suggested to be indirect effects of systemic inflammatory and immunological responses to SARS-CoV-2 infection, as endothelial cells and neurons are less susceptible to viral infection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

Clinical significance of serum miR-101-3p expression in patients with neonatal sepsis

Juan Zhang et al.

Summary: The study identified elevated expression of miR-101-3p in neonatal sepsis patients, which was closely related to clinical parameters and may ameliorate inflammation responses by negatively regulating DUSP1.

PERSONALIZED MEDICINE (2021)

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Article Cell Biology

microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis

Richard Y. Kim et al.

Summary: miR-21 aberrant expression in COPD is associated with lung disease and can be a therapeutic target. Using a specific miR-21 inhibitor can effectively prevent and treat COPD, improving lung function.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Medical Laboratory Technology

Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

David De Gonzalo-Calvo et al.

Summary: This study demonstrated a close association between the circulating miRNA profile of COVID-19 patients and disease severity. Analysis of miRNA levels proved useful in distinguishing between ICU patients and ward patients, as well as between ICU nonsurvivors and survivors. The potential of miRNA signatures in predicting disease progression in critical COVID-19 patients was found to be superior to traditional laboratory parameters such as leukocyte counts, CRP, and D-dimer levels.

TRANSLATIONAL RESEARCH (2021)

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Article Virology

Comparison of SARS-CoV-2 Receptors Expression in Primary Endothelial Cells and Retinoic Acid-Differentiated Human Neuronal Cells

Francesca Benedetti et al.

Summary: Research demonstrates that SARS-CoV-2 virus can infect lung epithelial cells, endothelial cells, and neuronal cells. Interaction between the Spike protein and cellular receptors may lead to cellular dysfunction. Neuronal cells and endothelial cells are potential targets for the virus.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences

Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

Emanuel Wyler et al.

Summary: Detailed analysis of SARS-CoV-2 infection in comparison with SARS-CoV reveals a stronger induction of innate immune response, including the upregulation of miRNA-155. Infected cells show broad upregulation of genes, while interferon beta/lambda genes and pro-inflammatory cytokines like IL-6 are expressed in only a small subset of cells. Time analysis suggests that interferon regulatory factors are activated before nuclear factor kappa B in response to infection, with heat shock protein 90 (HSP90) identified as a relevant protein for viral replication and inflammatory cytokine expression.

ISCIENCE (2021)

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Article Pathology

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein *

Gerard J. Nuovo et al.

Summary: Neurologic complications of symptomatic COVID-19 are commonly seen, with brain tissues from autopsies showing the presence of pseudovirions in endothelial cells. The spike protein was found to induce ACE2+ endothelial damage, highlighting its central role in SARS-CoV2 pathology. Immunohistochemistry for caspase-3 and ACE2 can be used by diagnostic pathologists to document endothelial cell damage in COVID-19.

ANNALS OF DIAGNOSTIC PATHOLOGY (2021)

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Letter Cardiac & Cardiovascular Systems

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Yuyang Lei et al.

CIRCULATION RESEARCH (2021)

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Article Cell Biology

Detection of Atherosclerosis by Small RNA-Sequencing Analysis of Extracellular Vesicle Enriched Serum Samples

Alex Hildebrandt et al.

Summary: The study analyzed serum-derived miRNA profiles from patients and volunteers to identify potential biomarkers for atherosclerosis. The differential expression analysis found 27 differentially expressed miRNAs in patients compared to healthy volunteers, with specific miRNA fingerprints for different atherosclerotic manifestations. Overrepresentation analysis revealed relevant biological processes related to atherosclerosis, indicating the potential of these miRNAs as biomarker candidates.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Identification of novel circulating microRNAs in advanced heart failure by next-generation sequencing

Alessandro Galluzzo et al.

Summary: The study aimed to assess risk stratification in patients with advanced chronic heart failure by analyzing circulating microRNA levels. Certain dysregulated miRNAs were identified to be associated with heart failure biomarkers and significantly improved prognostic stratification of heart failure patients. Further validation in larger populations is needed to confirm these results.

ESC HEART FAILURE (2021)

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Article Multidisciplinary Sciences

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization

Gita A. Pathak et al.

Summary: This study integrates genome-wide association study data with mRNA expression, splicing, and protein levels to identify genes and pathways related to COVID-19 hospitalization, highlighting putative causal genes impacting disease severity and symptomology.

NATURE COMMUNICATIONS (2021)

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Article Microbiology

Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients

Jonathan Youngs et al.

Summary: The activation of MAIT cells in critically ill COVID-19 patients is a significant predictor of death and is associated with other mortality-associated immunologic measures. Additionally, a shift from focused IFN alpha-driven signals to broad pro-inflammatory responses in fatal COVID-19 patients was observed, which was not seen in severe influenza cases. The study identified key potential biomarkers and targetable pathways in critical viral illnesses, shared between influenza and COVID-19, with some unique to each infection.

PLOS PATHOGENS (2021)

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Article Microbiology

Altered microRNA expression in COVID-19 patients enables identification of SARS-CoV-2 infection

Ryan J. Farr et al.

Summary: This study analyzed the host miRNA response to COVID-19 and identified a three-miRNA signature that can independently classify COVID-19 cases with high accuracy. The findings suggest that miRNA profiling could potentially improve COVID-19 detection and patient management.

PLOS PATHOGENS (2021)

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Article Microbiology

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

Martina Severa et al.

Summary: The study highlights the crucial role of pDC/type I IFN axis in defending against SARS-CoV-2 infection in COVID-19 patients, suggesting that a deeper understanding may aid in the development of new drug strategies and host-directed therapies. Moreover, the findings indicate that critically ill patients exhibit impaired type I IFN response and high levels of inflammatory cytokines and chemokines, leading to multi-organ failure.

PLOS PATHOGENS (2021)

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Article Cell Biology

Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2

Jae Hyun Park et al.

Summary: Extracellular vesicles are nanometer-scaled, membrane-bound materials released by cells, containing diverse contents such as proteins and nucleic acids. These vesicles have shown potential as therapeutic agents for SARS-CoV-2 infection by inhibiting viral replication and mediating anti-viral responses through miRNAs.

CELLS (2021)

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Article Hematology

Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

Ning Tang et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Review Cardiac & Cardiovascular Systems

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

Masataka Nishiga et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Article Virology

Modelling West Nile Virus and Usutu Virus Pathogenicity in Human Neural Stem Cells

Silvia Riccetti et al.

VIRUSES-BASEL (2020)

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Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

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Article Multidisciplinary Sciences

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Prabhu S. Arunachalam et al.

SCIENCE (2020)

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Review Medicine, General & Internal

Cytokine Storm

David C. Fajgenbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Toxicology

High expression of miR-483-5p aggravates sepsis-induced acute lung injury

Chenghui Leng et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2020)

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Article Critical Care Medicine

Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock

Yang Jiao et al.

CRITICAL CARE (2020)

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Review Cell Biology

Regulation of microRNA function in animals

Luca F. R. Gebert et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Cell Biology

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

Thomas Treiber et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

Dongchao Lu et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Article Biochemical Research Methods

MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis

Valerio Licursi et al.

BMC BIOINFORMATICS (2019)

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Article Biochemistry & Molecular Biology

miRBase: from microRNA sequences to function

Ana Kozomara et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Biochemistry & Molecular Biology

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research

Denise N. Slenter et al.

NUCLEIC ACIDS RESEARCH (2018)

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Article Multidisciplinary Sciences

miRWalk: An online resource for prediction of microRNA binding sites

Carsten Sticht et al.

PLOS ONE (2018)

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Article Biochemistry & Molecular Biology

MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses to influenza whole-virus vaccine

Masaaki Okamoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Cardiac & Cardiovascular Systems

miR-30c-5p regulates macrophage-mediated inflammation and pro-atherosclerosis pathways

Giulio Ceolotto et al.

CARDIOVASCULAR RESEARCH (2017)

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Article Biochemistry & Molecular Biology

KEGG as a reference resource for gene and protein annotation

Minoru Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2016)

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Article Oncology

MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS)

Shengfeng Wan et al.

ONCOTARGET (2016)

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Review Immunology

MicroRNAs as regulatory elements in immune system logic

Arnav Mehta et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Article Immunology

Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function

Leonid A. Pobezinsky et al.

NATURE IMMUNOLOGY (2015)

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Review Immunology

MicroRNA as type I interferon-regulated transcripts and modulators of the innate immune response

Samuel C. Forster et al.

FRONTIERS IN IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data

Warren A. Kibbe et al.

NUCLEIC ACIDS RESEARCH (2015)

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Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

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Review Genetics & Heredity

Regulation of the MIR155 host gene in physiological and pathological processes

Terry S. Elton et al.

GENE (2013)

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Article Biochemical Research Methods

Calculating Sample Size Estimates for RNA Sequencing Data

Steven N. Hart et al.

JOURNAL OF COMPUTATIONAL BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes

Damon Polioudakis et al.

NUCLEIC ACIDS RESEARCH (2013)

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Review Genetics & Heredity

MicroRNA profiling: approaches and considerations

Colin C. Pritchard et al.

NATURE REVIEWS GENETICS (2012)

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Article Biotechnology & Applied Microbiology

MicroRNAs and their isomiRs function cooperatively to target common biological pathways

Nicole Cloonan et al.

GENOME BIOLOGY (2011)

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Article Immunology

Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1

Pin Wang et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Cell Biology

Altered microRNA expression in human heart disease

Sadakatsu Ikeda et al.

PHYSIOLOGICAL GENOMICS (2007)

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Article Multidisciplinary Sciences

Requirement of bic/microRNA-155 for normal immune function

Antony Rodriguez et al.

SCIENCE (2007)

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Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

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Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

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