☆ 4.8 Review

Hyperthermia combined with immune checkpoint inhibitor therapy in the treatment of primary and metastatic tumors

FRONTIERS IN IMMUNOLOGY (2022)

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Review Chemistry, Medicinal

Enhancement of CD8+ T-Cell-Mediated Tumor Immunotherapy via Magnetic Hyperthermia

Yihan Zhang et al.

Summary: Magnetic hyperthermia (MHT) utilizes magnetic iron oxide nanoparticles to heat up in an alternating magnetic field, triggering biological effects for tumor killing. Combining MHT with immunotherapy can enhance antitumor effects synergistically, preventing cancer recurrence and metastasis, and prolonging survival.

CHEMMEDCHEM (2022)

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Article Materials Science, Biomaterials

Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity

Pei-Ying Huang et al.

Summary: The study developed ICGCQ@RCm NPs to enhance tumor LTPTT by prolonging blood drug circulation, enhancing drug accumulation in tumor tissues, reducing thermal tolerance of tumor cells, and inducing immunogenic cell death. The NPs also optimized therapeutic efficacy through imaging-guided LTPTT and showed high biosafety, with potential for clinical application using FDA-approved drugs.

BIOMATERIALS SCIENCE (2022)

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Article Immunology

Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells

Muxin Yu et al.

Summary: Microwave ablation (MWA) of primary breast cancer activates NK cells, inhibiting lung metastasis and improving survival. NK cells exhibit enhanced cytotoxic functions post-MWA, playing a pivotal role in this process.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

NK cells and ILCs in tumor immunotherapy

Simona Sivori et al.

Summary: Innate immune cells, especially NK cells, play an important role in tumor immunotherapy by controlling tumor growth and metastasis. Various approaches have been developed, such as using IL-15 to improve NK cell function and utilizing NK cell engagers to activate NK cells. Additionally, NK cells may express inhibitory checkpoints like PD-1, which can be targeted for therapeutic use against certain tumors.

MOLECULAR ASPECTS OF MEDICINE (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy

Mengyu Chang et al.

Summary: Hyperthermia therapy has emerged as a strategy against malignant tumors, particularly when combined with nanomaterial-based photothermal therapy or magnetic hyperthermia. While these treatments alone may not completely cure cancer, when combined with cancer immunotherapy, they have shown potential for enhanced therapeutic outcomes against both primary tumors and metastatic lesions, as well as preventing cancer recurrence and prolonging survival period.

ADVANCED MATERIALS (2021)

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Review Medicine, Research & Experimental

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

Sreya Bagchi et al.

Summary: This article highlights the significance of immune checkpoint inhibitors in cancer immunotherapy and the research findings on the changes in local and systemic immune cells after treatment. It emphasizes the need for understanding the requirements for an effective and safe antitumor immune response following ICI therapy.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

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Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Oncology

Targeting hypoxic tumor microenvironment in pancreatic cancer

Jinxin Tao et al.

Summary: Pancreatic cancer, characterized by late diagnosis, early metastasis, and poor prognosis, exhibits high lethality globally. The hypoxic microenvironment in pancreatic cancer has extensive effects on biological behaviors and malignant phenotypes, leading to aggressive progression and therapeutic resistance. Innovative therapies targeting the tumor hypoxic microenvironment show great potential in overcoming treatment resistance and enhancing antitumor efficacy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer

Brett Z. Fite et al.

Summary: High intensity focused ultrasound (HIFU) can rapidly and non-invasively destroy tumor tissue. A combination of HIFU with innate immune agonist CpG and checkpoint inhibitor anti-PD-1 can modulate the immune response, leading to enhanced anti-tumor effects. Both mechanical disruption HIFU and thermal ablation induce potent inflammatory responses, while priming with CpG can further enhance immune response, alter macrophage polarization, and increase T-cell activation.

SCIENTIFIC REPORTS (2021)

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Article Engineering, Biomedical

Recent Progress in the Synergistic Combination of Nanoparticle-Mediated Hyperthermia and Immunotherapy for Treatment of Cancer

Zachary R. Stephen et al.

Summary: Immunotherapy has shown success in certain cancers, and combinational approaches with hyperthermia therapy are being explored to enhance its effectiveness. Nanoparticle-based hyperthermia increases tumor immunogenicity and permeability, particularly effective in solid tumors.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Pharmacology & Pharmacy

Enhancement of Therapies for Glioblastoma (GBM) Using Nanoparticle-based Delivery Systems

Kanawat Wiwatchaitawee et al.

Summary: Glioblastoma multiforme (GBM) is an aggressive brain tumor, with current treatments including surgery, radiation, and chemotherapy, while nanoparticle-mediated delivery systems show promise. Drug delivery via nanoparticles can reduce toxicity, increase specificity, and improve survival and quality of life for GBM patients.

AAPS PHARMSCITECH (2021)

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Article Oncology

Nivolumab and Ipilimumab as Maintenance Therapy in Extensive-Disease Small-Cell Lung Cancer: CheckMate 451

Taofeek K. Owonikoko et al.

Summary: Maintenance therapy with nivolumab plus ipilimumab did not prolong overall survival (OS) for patients with extensive-disease small-cell lung cancer (ED-SCLC) who did not progress on first-line chemotherapy. However, there may be a benefit of nivolumab plus ipilimumab in patients with a tumor mutational burden of >= 13 mutations per megabase. The rates of grade 3-4 treatment-related adverse events were highest in the nivolumab plus ipilimumab group.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

M2-Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy

Wenrong Zhao et al.

Summary: The study established a stimuli-responsive multifunctional nanoplatform that can enhance the infiltration of T lymphocytes and promote immune responses by cutting off PD-L1 and CD47 signals. It effectively suppresses the development of breast cancer, reverses pro-tumor macrophages to anti-tumor ones, offering a promising strategy for developing highly efficient and low-toxic immunotherapy based on nanotechnology.

SMALL (2021)

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Review Oncology

Durvalumab: A Review in Extensive-Stage SCLC

Zaina T. Al-Salama

Summary: Durvalumab, a fully human monoclonal antibody against PD-L1, when used in combination with chemotherapy in first-line treatment of extensive-stage small cell lung cancer, has shown significantly longer overall survival, higher objective response rate, and manageable tolerability profile. This combination therapy represents a valuable treatment option and an accepted standard of care for these patients.

TARGETED ONCOLOGY (2021)

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Article Engineering, Biomedical

Mild hyperthermia promotes immune checkpoint blockade-based immunotherapy against metastatic pancreatic cancer using size-adjustable nanoparticles

Qianwen Yu et al.

Summary: The combination of mild hyperthermia and immune checkpoint blockade treatment effectively suppressed tumor growth and metastasis; size-adjustable nanoparticles have great potential in improving cancer treatment outcomes.

ACTA BIOMATERIALIA (2021)

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Article Pharmacology & Pharmacy

Elucidating the Innate Immunological Effects of Mild Magnetic Hyperthermia on U87 Human Glioblastoma Cells: An In Vitro Study

Stefano Persano et al.

Summary: The study found that local mild thermal treatment can induce immunogenic cell death in U87 glioblastoma cells, modulating their immune profile and increasing their susceptibility to macrophage killing. Additionally, it was demonstrated that mild thermal treatment can modulate the expression of inhibitory and activating NK cell ligands in U87 cells, enhancing their susceptibility to NK cell killing.

PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Mild Magnetic Hyperthermia-Activated Innate Immunity for Liver Cancer Therapy

Jiong Pan et al.

Summary: Magnetic hyperthermia therapy using specially designed composite magnetic nanoparticles showed high efficacy in inhibiting liver cancer cell proliferation and tumor growth by controlling mild hyperthermia at 43-44 degrees Celsius. This treatment also activated natural killer cells and suppressed tumor growth by upregulating UL16-binding proteins, providing a promising approach for liver cancer treatment via induced NK-cell-related antitumor immunity.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Medicine, General & Internal

Breast cancer

Sibylle Loibl et al.

Summary: Breast cancer diagnosis and treatment have become increasingly complex, incorporating various biomarkers and neoadjuvant therapies, with de-escalation schemes for radiotherapy now becoming standard practice.

LANCET (2021)

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Article Health Care Sciences & Services

Long-term efficacy and adverse reactions of IMRT combined with Endostar versus IMRT combined with chemotherapy for locally advanced nasopharyngeal carcinoma: a retrospective study

Wei Chen et al.

Summary: The study aimed to compare the long-term efficacy and late adverse reactions of intensity-modulated radiation therapy (IMRT) combined with recombinant human endostatin (Endostar) versus IMRT combined with concurrent chemotherapy (CCT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Results showed no significant difference in overall survival rates between the two groups, but the IMRT + Endostar group displayed better efficacy and less severe late side effects. More research with a larger sample size and longer follow-up period is needed.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Review Oncology

Innate Immune Checkpoint Inhibitors: The Next Breakthrough in Medical Oncology?

Robert W. Lentz et al.

Summary: While immunotherapy has revolutionized the treatment of many types of advanced cancer, most patients still do not derive benefit. Innate immune checkpoint inhibitors are a promising new target that can disrupt inhibitory interactions between tumor and both phagocytes and natural killer cells. This area of drug development targeting phagocytosis and natural killer-cell checkpoints could revolutionize immune-based cancer therapies.

MOLECULAR CANCER THERAPEUTICS (2021)

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Article Multidisciplinary Sciences

Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor

Wan Fatin Amira Wan Mohd Zawawi et al.

Summary: Near infrared radiation heat therapy can effectively slow down the progression of breast tumors, enhance activation and infiltration of immune cells, and increase the median survival of mice with tumors.

SCIENTIFIC REPORTS (2021)

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Review Nanoscience & Nanotechnology

Recent Advancements in Nanomedicine for 'Cold' Tumor Immunotherapy

Qinjun Chen et al.

Summary: Despite the high clinical success rate of current anticancer immunotherapies using immune check-point inhibitors (ICIs), many patients with 'cold' tumors still respond poorly to ICI therapy due to insufficient T cell infiltration and low immunogenicity. Advances in precision medicine and nanotechnology have shown promise in improving treatment for these patients by targeting the immunosuppressive tumor immune microenvironment in cold tumors.

NANO-MICRO LETTERS (2021)

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Review Immunology

Immune Modulation Plus Tumor Ablation: Adjuvants and Antibodies to Prime and Boost Anti-Tumor Immunity In Situ

Renske J. E. van den Bijgaart et al.

Summary: In situ tumor ablation techniques generate tumor debris serving as immunogenic antigens, but studies show modest tumor-directed immune responses. Immune stimuli provision and counteraction of immunosuppressive tumor microenvironment are crucial to enhance ablation-induced anti-tumor immunity. Novel multifunctional antibody formats offer potential in delivering immunomodulators and boosting anti-tumor immunity with reduced toxic side effects.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Neoantigen: A New Breakthrough in Tumor Immunotherapy

Zheying Zhang et al.

Summary: Cancer immunotherapy enhances the body's immune response to target and eliminate cancer cells, with a focus on the emerging approach of tumor neoantigens. Studies have shown the relationship between neoantigens and T cell recognition of cancer cells, highlighting the potential of vaccines developed against these specific antigens in clinical trials.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Engineering, Biomedical

Photothermal therapy mediated by gold nanocages composed of anti-PDL1 and galunisertib for improved synergistic immunotherapy in colorectal cancer

Siyu Wang et al.

Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Nanomedicine-based photothermal therapy (PTT) has shown promising results for solid tumor ablation, providing a potential therapeutic strategy for CRC.

ACTA BIOMATERIALIA (2021)

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Article Biochemistry & Molecular Biology

Surface charge transition nano-theranostics based on ultra-small Fe3O4 nanoparticles for enhanced photodynamic and photothermal therapy against nasopharyngeal carcinoma

Naveen Kumar Bejjanki et al.

Summary: Platinum-based concurrent chemo-radiotherapy is a common treatment for Nasopharyngeal carcinoma, but it has low efficacy and side effects. Photothermal therapy (PTT) and photodynamic therapy (PDT) have been developed as non-invasive modalities to improve cancer therapy. The developed acidity surface charge transformable nanocluster (NCs) shows enhanced synergistic PDT/PTT effects in in vitro and in vivo experiments, suggesting its potential as a nano theranostic agent for cancer therapy.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Review Pharmacology & Pharmacy

Gold nanostructures as mediators of hyperthermia therapies in breast cancer

Andreia Granja et al.

Summary: Breast cancer is the leading cause of cancer-related deaths among women, and new treatment options are needed due to limitations of current therapeutics. Hyperthermia, particularly in combination with chemotherapy and radiotherapy, shows promise in improving breast cancer therapy. The association of hyperthermia with nanotechnology, such as photothermal therapy (PTT), has gained attention and gold nanostructures are emerging as excellent PTT agents for breast cancer management.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Cell Biology

Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells

Tetsuya Kagawa et al.

Summary: This study demonstrates a novel hyperthermia technology, immuno-MHT, for selective cancer therapy targeting individual cancer cells.

CELL CYCLE (2021)

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Review Medicine, General & Internal

Pancreatic Cancer: A Review

Wungki Park et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer with increasing incidence each year, resulting in a high percentage of patients being diagnosed with advanced disease. Current cytotoxic therapies for PDAC are moderately effective, emphasizing the importance of multidisciplinary management, comprehensive germline testing, and integrated supportive care for all patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

Pancreatic adenocarcinoma presenting with Cushing's syndrome

Ioannis Karniadakis et al.

LANCET (2021)

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Editorial Material Medicine, General & Internal

Adjuvant metronomic chemotherapy for locoregionally advanced nasopharyngeal carcinoma Comment

Robert S. Kerbel et al.

LANCET (2021)

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Article Medicine, General & Internal

Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial

Yu-Pei Chen et al.

Summary: This study found that adding oral metronomic capecitabine as adjuvant chemotherapy significantly improved failure-free survival in patients with high-risk locoregionally advanced nasopharyngeal carcinoma, with a good safety profile. These results support the potential role of metronomic chemotherapy as an adjuvant therapy in the treatment of nasopharyngeal carcinoma.

LANCET (2021)

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Review Biotechnology & Applied Microbiology

Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Mona G. Alharbi et al.

Summary: Extracellular vesicles (EVs), such as exosomes, are nanosized membrane-enveloped vesicles containing diverse bioactive cargo. EVs derived from stem cells can be preconditioned to produce vesicles with different therapeutic properties, particularly with respect to heat-shock proteins. Heat-shock proteins play crucial roles in cellular protection and resistance to various therapeutic treatments.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Biotechnology & Applied Microbiology

Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy

Qinmin Liu et al.

Summary: The synthesized USPIO-PEG-sLe(x) nanoparticles demonstrate excellent photothermal conversion properties and showed significant cytotoxic effects on NPC cells in vitro. Additionally, they could target the tumor area and reduce the T2* value of tumor tissue. This nanotheranostic platform may serve as a new strategy for treating NPC.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Immunology

CD8+ T Cell Exhaustion in Cancer

Joseph S. Dolina et al.

Summary: Recent research has revealed the heterogeneity within the exhausted CD8(+) T cell lineage, which consists of multiple interconnected subpopulations with distinct characteristics and locations. This understanding calls for a re-focusing of cancer immunotherapies on targeting the driver mechanisms underlying CD8(+) T(ex) development to stabilize functional subsets.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Endocrinology & Metabolism

Clinical Effects of Microwave Ablation in the Treatment of Low-Risk Papillary Thyroid Microcarcinomas and Related Histopathological Changes

Chenya Lu et al.

Summary: Ultrasound-guided percutaneous microwave ablation is a safe and effective treatment for low-risk papillary thyroid microcarcinoma, with significant reduction in tumor volume and some cases achieving complete remission. The most common histopathological changes after MWA include fibroblastic proliferation and chronic inflammation. Thyroid function may transiently decrease after MWA but returns to normal thereafter, and no serious complications were reported.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Chemistry, Multidisciplinary

Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia

Alba Nicolas-Boluda et al.

Summary: This study reveals that gold decorated iron oxide nanoflowers (GIONF) can significantly impact the tumor immune environment, promoting recruitment of monocytes and creating a pro-inflammatory anti-tumor microenvironment. Furthermore, mild hyperthermia treatment also leads to an increase in CD8+ T lymphocytes and pro-inflammatory cytokines in addition to GIONF effects.

NANOSCALE (2021)

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Article Oncology

Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins

Yasen Maimaitiyiming et al.

Summary: Hyperthermia destabilizes oncofusion proteins, including drug-resistant mutants like PML/RARα, and may improve prognosis in acute promyelocytic leukemia through promoting protein degradation. This approach of utilizing biophysical vulnerabilities of fusion oncoproteins could be a paradigm for therapeutically targeting related cancers with hyperthermia.

BLOOD CANCER DISCOVERY (2021)

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Article Biochemical Research Methods

Protocol Protocol for fever-range whole-body hyperthermia (WBH) in mice to study febrile effect on T-cell adhesion and migration

ChangDong Lin et al.

Summary: This article presents a protocol for treating mice with WBH and evaluating T-cell adhesion and transmigration, which can be applied to studying fever-induced immune system dysfunction. For more details, please refer to Lin et al. (2019).

STAR PROTOCOLS (2021)

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Article Oncology

Whole-body hyperthermia combined with chemotherapy and intensity-modulated radiotherapy for treatment of advanced nasopharyngeal carcinoma: a retrospective study with propensity score matching

Naiying Zheng et al.

Summary: This study evaluated the efficacy of combining radiotherapy, chemotherapy, and whole-body hyperthermia in treating locoregionally advanced nasopharyngeal carcinoma (NPC). The results suggest that whole-body hyperthermia, when combined with CRT, can improve the overall survival of patients with advanced NPC, but has no significant impact on other survival outcomes.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2021)

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Article Multidisciplinary Sciences

Pulsed focused ultrasound can improve the anti-cancer effects of immune checkpoint inhibitors in murine pancreatic cancer

Petros X. E. Mouratidis et al.

Summary: The study showed that pulsed high-intensity focused ultrasound (pHIFU) combined with immune checkpoint inhibitors (ICI) has the potential to enhance survival in pancreatic cancer therapy based on increased infiltration of CD8(+) T cells and extended survival in treated subjects compared to controls.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2021)

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Article Materials Science, Biomaterials

Multifunctional l-arginine-based magnetic nanoparticles for multiple-synergistic tumor therapy

Haiyan Yang et al.

Summary: This study presents high-intensity focused ultrasound-responsive magnetic nanoparticles for synergistic breast cancer therapy, showing enhanced therapeutic effects by accumulating and retaining at the tumor site under magnetic guidance. The nanoparticles exhibit synergistic therapeutic effects through rational combination of ultrasound-based tumor ablation and nitric oxide-assisted antitumor gas therapy, resulting in effective tumor growth suppression.

BIOMATERIALS SCIENCE (2021)

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Article Oncology

Incomplete thermal ablation of tumors promotes increased tumorigenesis

Aurelia Markezana et al.

Summary: The study showed that partial RFA of a target tumor can stimulate residual tumor cells to induce accelerated growth of distant tumors via the IL-6/c-Met/HGF pathway and VEGF production.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2021)

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Article Oncology

Low-dose ipilimumab plus nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series of 131 stage IV cancers - a retrospective study of a single institution

R. Kleef et al.

Summary: This study found a safer and effective treatment approach through combination therapy for patients with 23 different types of cancers, offering good efficacy without compromising safety.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Article Medicine, Research & Experimental

Magnetism-mediated targeting hyperthermia-immunotherapy in cold tumor with CSF1R inhibitor

Yuefei Fang et al.

Summary: The study demonstrated that the targeted delivery of CSF1R inhibitor using magnetic liposomes, along with magnetic hyperthermia, can remodel the tumor microenvironment, activate immune responses, and inhibit tumor growth and recurrence.

THERANOSTICS (2021)

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Article Chemistry, Multidisciplinary

Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments

Jiong Pan et al.

ACS NANO (2020)

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Review Pharmacology & Pharmacy

Molecular and biological rationale of hyperthermia as radio- and chemosensitizer

A. L. Oei et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Biotechnology & Applied Microbiology

Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy

Hongwei Chen et al.

NANOMEDICINE (2020)

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Article Multidisciplinary Sciences

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

NATURE (2020)

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Article Oncology

Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy

Shibin Qu et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Immunology

NK Cell-Based Immune Checkpoint Inhibition

Muhammad Khan et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Nanoscience & Nanotechnology

Direct treatment versus indirect: Thermo-ablative and mild hyperthermia effects

Macy Payne et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020)

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Review Immunology

The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies

Florent Petitprez et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy

Michael Dunne et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Percutaneous Ablation-Induced Immunomodulation in Hepatocellular Carcinoma

Lucile Dumolard et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Pharmacology & Pharmacy

Emerging hyperthermia applications for pediatric oncology

Caitlin Tydings et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Biology

Hyperthermia and protein homeostasis: Cytoprotection and cell death

Kanwal Ahmed et al.

JOURNAL OF THERMAL BIOLOGY (2020)

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Article Nanoscience & Nanotechnology

Preparation and Evaluation of Doxorubicin-Loaded PLA-PEG-FA Copolymer Containing Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for Cancer Treatment: Combination Therapy with Hyperthermia and Chemotherapy

Mohammad Khaledian et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Oncology

Thermal Ablation for Papillary Thyroid Microcarcinoma: How Far We Have Come?

Yu Min et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Correction Oncology

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death (vol 8, e000337, 2020)

Lorenzo Galluzzi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Immunology

Therapeutic strategies to remodel immunologically cold tumors

Minyu Wang et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

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Review Immunology

Hyperthermia Targeting the Tumor Microenvironment Facilitates Immune Checkpoint Inhibitors

Zihui Li et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Oncology

Expert consensus workshop report: Guidelines for thermal ablation of thyroid tumors (2019 edition)

Dong Xu et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2020)

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Article Oncology

Exosomes released by breast cancer cells under mild hyperthermic stress possess immunogenic potential and modulate polarizationin vitroin macrophages

Kacoli Sen et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2020)

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Review Medicine, Research & Experimental

Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology

Jun Yang et al.

THERANOSTICS (2020)

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Article Oncology

Overcoming Radioresistance: Small Molecule Radiosensitisers and Hypoxia-activated Prodrugs

R. K. Jackso et al.

CLINICAL ONCOLOGY (2019)

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Review Oncology

Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System

Shweta Joshi et al.

JOURNAL OF ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

Mauro Poggio et al.

CELL (2019)

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Article Chemistry, Multidisciplinary

Iron Nanoparticles for Low-Power Local Magnetic Hyperthermia in Combination with Immune Checkpoint Blockade for Systemic Antitumor Therapy

Yu Chao et al.

NANO LETTERS (2019)

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Review Cell Biology

Immunogenic cell death in cancer therapy: Present and emerging inducers

Jingyi Zhou et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Oncology

Advances in cancer immunotherapy 2019-latest trends

Stephan Kruger et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Immunology

Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory

Yang Liu et al.

IMMUNOTHERAPY (2019)

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Article Nanoscience & Nanotechnology

Photothermal-Chemotherapy Integrated Nanoparticles with Tumor Microenvironment Response Enhanced the Induction of Immunogenic Cell Death for Colorectal Cancer Efficient Treatment

Yayu Wen et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Oncology

Immune correlates of clinical benefit in a phase I study of hyperthermia with adoptive T cell immunotherapy in patients with solid tumors

Guoliang Qiao et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2019)

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Article Oncology

Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer

Arlene L. Oei et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2019)

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Review Endocrinology & Metabolism

Thermal Ablation for Small Papillary Thyroid Cancer: A Systematic Review

Se Jin Cho et al.

THYROID (2019)

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Article Multidisciplinary Sciences

Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

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NATURE COMMUNICATIONS (2019)

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Article Immunology

A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer

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FRONTIERS IN IMMUNOLOGY (2019)

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Review Oncology

Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors

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JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Surface-Functionalized Modified Copper Sulfide Nanoparticles Enhance Checkpoint Blockade Tumor Immunotherapy by Photothermal Therapy and Antigen Capturing

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ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Oncology

The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors

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INTEGRATIVE CANCER THERAPIES (2019)

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Immunomodulation characteristics by thermal ablation therapy in cancer patients

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ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2018)

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eIF2α phosphorylation is pathognomonic for immunogenic cell death

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CELL DEATH AND DIFFERENTIATION (2018)

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Article Immunology

Exosomes from heat-stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL-6

Danfeng Guo et al.

IMMUNOLOGY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Enhanced antitumor efficacy through microwave ablation in combination with immune checkpoints blockade in breast cancer: A pre-clinical study in a murine model

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DIAGNOSTIC AND INTERVENTIONAL IMAGING (2018)

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Review Immunology

Gold nanoparticles-mediated photothermal therapy and immunotherapy

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IMMUNOTHERAPY (2018)

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Review Immunology

Natural Killer Cells: Development, Maturation, and Clinical Utilization

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FRONTIERS IN IMMUNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation

Travis Cantu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer

Li Li et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

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Review Biotechnology & Applied Microbiology

Complex effects of tumor microenvironment on the tumor disposition of carrier-mediated agents

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NANOMEDICINE (2017)

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Prussian blue nanoparticle-based photothermal therapy combined with checkpoint inhibition for photothermal immunotherapy of neuroblastoma

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Article Cell Biology

The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response

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CELL DEATH & DISEASE (2017)

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Review Cell Biology

Exosomes in cancer theranostic: Diamonds in the rough

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CELL ADHESION & MIGRATION (2017)

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Review Biotechnology & Applied Microbiology

Clinical Applications of Immunotherapy Combination Methods and New Opportunities for the Future

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BIOMED RESEARCH INTERNATIONAL (2017)

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Review Radiology, Nuclear Medicine & Medical Imaging

Thermal ablation and immunomodulation: From preclinical experiments to clinical trials

H. Takaki et al.

DIAGNOSTIC AND INTERVENTIONAL IMAGING (2017)

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Review Oncology

Resistance to PD1/PDL1 checkpoint inhibition

Jake S. O'Donnell et al.

CANCER TREATMENT REVIEWS (2017)

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A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling

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CLINICAL CANCER RESEARCH (2016)

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Review Oncology

Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms

Nathalie van den Tempel et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2016)

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Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

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NATURE COMMUNICATIONS (2016)

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Review Oncology

Classifying Cancers Based on T-cell Infiltration and PD-L1

Michele W. L. Teng et al.

CANCER RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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Article Chemistry, Multidisciplinary

Cu2-xSe@mSiO(2)-PEG core-shell nanoparticles: a low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density

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Article Oncology

Effector CD8(+) T cell IFN-gamma production and cytotoxicity are enhanced by mild hyperthermia

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INTERNATIONAL JOURNAL OF HYPERTHERMIA (2012)

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Article Oncology

Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients

Haijun Zhong et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2011)

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Graphene in Mice: Ultrahigh In Vivo Tumor Uptake and Efficient Photothermal Therapy

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NANO LETTERS (2010)

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Article Biochemistry & Molecular Biology

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells

K. Lin et al.

ONCOGENE (2008)

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Article Oncology

Pattern of carcinoembryonic antigen drop after laparoscopic radiofrequency ablation of liver metastasis from colorectal carcinoma

Mohammed Ghanamah et al.

CANCER (2006)

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PSA elevation during prostate cryosurgery and subsequent decline

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