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Hyperthermia combined with immune checkpoint inhibitor therapy in the treatment of primary and metastatic tumors

期刊

FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.969447

关键词

thermal ablation; mild hyperthermia; immune checkpoint inhibitor; malignant tumor; combined therapy

资金

  1. National Natural Science Foundation of China [81874408]
  2. Project of the Hunan Provincial Department of Education [21B0359]
  3. Project of Hunan Provincial Health Commission [202207015643]
  4. Domestic First-Class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine [2022ZYX03]

向作者/读者索取更多资源

Thermotherapy can be divided into thermal ablation and mild hyperthermia based on temperature difference. Both therapies have advantages in targeting tumors and inhibiting metastasis, but neither induces sustained systemic immunity. This paper summarizes the research on hyperthermia combined with immune checkpoint inhibitor (ICI) therapies and compares the efficacy of the two combinations to provide a better treatment for the recurrence and metastasis of malignant tumors.
According to the difference in temperature, thermotherapy can be divided into thermal ablation and mild hyperthermia. The main advantage of thermal ablation is that it can efficiently target tumors in situ, while mild hyperthermia has a good inhibitory effect on distant metastasis. There are some similarities and differences between the two therapies with respect to inducing anti-tumor immune responses, but neither of them results in sustained systemic immunity. Malignant tumors (such as breast cancer, pancreatic cancer, nasopharyngeal carcinoma, and brain cancer) are recurrent, highly metastatic, and highly invasive even after treatment, hence a single therapy rarely resolves the clinical issues. A more effective and comprehensive treatment strategy using a combination of hyperthermia and immune checkpoint inhibitor (ICI) therapies has gained attention. This paper summarizes the relevant preclinical and clinical studies on hyperthermia combined with ICI therapies and compares the efficacy of two types of hyperthermia combined with ICIs, in order to provide a better treatment for the recurrence and metastasis of clinically malignant tumors.

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