☆ 4.8 Article

Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression

FRONTIERS IN IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Genetics & Heredity

Characteristics of the Immune Cell Infiltration Landscape in Gastric Cancer to Assistant Immunotherapy

Chenlu Li et al.

Summary: This study identified three subtypes of gastric cancer based on immune cell infiltration scores, with low ICI scores associated with increased tumor mutation burden and the immune-activating signaling pathways, while high ICI scores were linked to immunosuppressive pathways and poor prognosis. Lower ICI scores were shown to exhibit significant therapeutic responses and clinical benefits in external immunotherapy and chemotherapy cohorts, highlighting the importance of ICI scores as predictive indicators for immunotherapy in gastric cancer.

FRONTIERS IN GENETICS (2022)

添加到收藏夹

Article Cell Biology

Immune Infiltration in Gastric Cancer Microenvironment and Its Clinical Significance

An Zhi Zhang et al.

Summary: Immunotherapy has rapidly developed and become an important method for treating gastric cancer. The presence of tumor infiltrating immune cells and immune-related genes in the tumor microenvironment greatly influence tumor progression and prognosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Identification and Validation of Immune Cells and Hub Genes in Gastric Cancer Microenvironment

Huan Wang et al.

Summary: This study identified five immune cells associated with infiltration and 20 hub genes, of which five genes were correlated with overall survival, through the analysis of gene expression profiles and clinical data. Furthermore, the expression differences of these hub genes in gastric cancer and adjacent tissues were detected using real-time PCR. This research provides potential targets for immunotherapy of gastric cancer and offers new insights for immunotherapy in various tumors.

DISEASE MARKERS (2022)

添加到收藏夹

Article Genetics & Heredity

Identification of three immune subtypes characterized by distinct tumor immune microenvironment and therapeutic response in stomach adenocarcinoma

Yimiao Zhu et al.

Summary: This study investigates the association between patient survival, tumor immune microenvironment (TIME), and therapeutic response in primary stomach adenocarcinoma (STAD). The results reveal that the TIME phenotypes of STAD patients can be classified into three different molecular subtypes, which display different prognoses, immune features, and therapeutic responses. These findings shed new light on predicting patient outcomes and the discovery of new anti-STAD therapeutic strategies based on TIME.

GENE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Characteristics of immunophenotypes and immunological in tumor microenvironment and analysis of immune implication of CXCR4 in gastric cancer

Fang Wen et al.

Summary: The study utilized machine learning algorithms to analyze the immunophenotypes and immunological characteristics of gastric cancer patients, finding a connection between C-X-C motif chemokine receptor 4 (CXCR4) and the gastric cancer immune microenvironment. The results indicated that CXCR4 could serve as a potential prognostic biomarker and immunotherapy target for gastric cancer.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Engineering, Biomedical

Single-Cell Sequencing Analysis Based on Public Databases for Constructing a Metastasis-Related Prognostic Model for Gastric Cancer

Rubin Xu et al.

Summary: In this study, we conducted transcriptome and single-cell sequencing analyses using public databases to explore the immune microenvironment of gastric cancer. We developed a prognostic model for gastric cancer patients and identified a candidate vaccine gene, PTPN6.

APPLIED BIONICS AND BIOMECHANICS (2022)

添加到收藏夹

Article Health Care Sciences & Services

Identification of Immune-Related Prognostic Markers in Gastric Cancer

Yanxin He et al.

Summary: In this study, the gene expression difference between gastric cancer (GC) and the control group was analyzed. Immune-related differentially expressed genes (DEGs) were identified and enriched. Differences in immune cell infiltration and immune function between GC and normal tissues were observed. Prognostic genes for GC were determined using Cox regression analysis and survival analysis in TCGA and GSE62254 datasets. The potential prognostic role of genes was further evaluated using a risk score. FABP4, LBP, LCN1, CMA1, INHBA, ANGPTL1, ACKR1, GHR, and OGN were identified as potential markers for monitoring the prognosis of GC in the future.

JOURNAL OF HEALTHCARE ENGINEERING (2022)

添加到收藏夹

Article Immunology

Tumor-infiltrating B cell is associated with the control of progression of gastric cancer

Zhonglin Ni et al.

Summary: The study found that B cell infiltration, especially class-switched memory B cells and plasma cells, in gastric cancer has a significant impact on tumor progression and prognosis. High levels of CD20+ B cell infiltration were significantly associated with improvements in overall survival and disease-free survival.

IMMUNOLOGIC RESEARCH (2021)

添加到收藏夹

Review Oncology

Tumor-Infiltrating Natural Killer Cells

Beatriz Cozar et al.

Summary: NK cells play a crucial role in immune responses to tumors by killing target cells and producing cytokines, but they can become dysfunctional in the immunosuppressive tumor microenvironment. This article provides an overview of NK tumor infiltration and surveillance, as well as the mechanisms by which NK cells become dysfunctional.

CANCER DISCOVERY (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Review Immunology

Top 10 Challenges in Cancer Immunotherapy

Priti S. Hegde et al.

IMMUNITY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

B cells are associated with survival and immunotherapy response in sarcoma

Florent Petitprez et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

Rita Cabrita et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

NATURE (2020)

添加到收藏夹

Review Oncology

The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target

V Gambardella et al.

CANCER TREATMENT REVIEWS (2020)

添加到收藏夹

Review Immunology

Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment

Kaiyue Wu et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Oncology

Lipid accumulation in macrophages confers protumorigenic polarization and immunity in gastric cancer

Qin Luo et al.

CANCER SCIENCE (2020)

添加到收藏夹

Article Oncology

Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial

Kohei Shitara et al.

JAMA ONCOLOGY (2020)

添加到收藏夹

Article Oncology

PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer

Soyoung A. Oh et al.

NATURE CANCER (2020)

添加到收藏夹

Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis

Yudan Chi et al.

SCIENCE (2020)

添加到收藏夹

Review Oncology

DNT Cell-based Immunotherapy: Progress and Applications

Yingrui Li et al.

JOURNAL OF CANCER (2020)

添加到收藏夹

Review Pathology

Tumor immune response and immunotherapy in gastric cancer

Yoonjin Kwak et al.

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Review Immunology

Tumour-intrinsic resistance to immune checkpoint blockade

Anusha Kalbasi et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Oncology

Tumor-infiltrating CD8+T cells combined with tumor-associated CD68+macrophages predict postoperative prognosis and adjuvant chemotherapy benefit in resected gastric cancer

Jun Lu et al.

BMC CANCER (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer

Daniel P. Hollern et al.

CELL (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

Qiming Zhang et al.

CELL (2019)

添加到收藏夹

Article Immunology

The Immune Landscape of Cancer

Vesteinn Thorsson et al.

IMMUNITY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression

Heng Lin et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

添加到收藏夹

Article Medicine, General & Internal

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

P. M. Forde et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Article Cell Biology

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

Peiming Zheng et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The Progress of T Cell Immunity Related to Prognosis in Gastric Cancer

Ming Wei et al.

BIOMED RESEARCH INTERNATIONAL (2018)

添加到收藏夹

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Hussein A. Tawbi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Review Gastroenterology & Hepatology

Resolving gastric cancer aetiology: an update in genetic predisposition

Paul C. Lott et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival

Geoffrey J. Markowitz et al.

JCI INSIGHT (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Advanced gastric adenocarcinoma: optimizing therapy options

Dilsa Mizrak Kaya et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

An Immune Atlas of Clear Cell Renal Cell Carcinoma

Stephane Chevrier et al.

CELL (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Yonit Lavin et al.

CELL (2017)

添加到收藏夹

Article Oncology

Cancer Statistics in China, 2015

Wanqing Chen et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Olivier De Henau et al.

NATURE (2016)

添加到收藏夹

Article Oncology

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression

Megan M. Kaneda et al.

CANCER DISCOVERY (2016)

添加到收藏夹

Article Oncology

CD163+CD14+macrophages, a potential immune biomarker for malignant pleural effusion

Fei Wang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

Jacob H. Levine et al.

CELL (2015)

添加到收藏夹

Article Biochemical Research Methods

Robust enumeration of cell subsets from tissue expression profiles

Aaron M. Newman et al.

NATURE METHODS (2015)

添加到收藏夹

Article Medicine, General & Internal

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

R. J. Motzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

添加到收藏夹

Article Oncology

CD19+CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in gastric cancer

Weiwei Wang et al.

ONCOTARGET (2015)

添加到收藏夹

Article Biotechnology & Applied Microbiology

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

El-ad David Amir et al.

NATURE BIOTECHNOLOGY (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

添加到收藏夹

Article Immunology

Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

Xiang-Liang Yuan et al.

CLINICAL IMMUNOLOGY (2010)

添加到收藏夹

Article Immunology

CD4+CD25+CD127low/- regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression

Li-Song Shen et al.

CLINICAL IMMUNOLOGY (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis

J Condeelis et al.

CELL (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.