4.8 Article

V2 hotspot optimized MVA vaccine expressing stabilized HIV-1 Clade C envelope Gp140 delays acquisition of heterologous Clade C Tier 2 challenges in Mamu-A*01 negative Rhesus Macaques

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Structure-guided changes at the V2 apex of HIV-1 Glade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies

Anusmita Sahoo et al.

Summary: HIV-1 Glade C envelope immunogens that elicit both neutralizing and non-neutralizing V1V2-scaffold-specific antibodies are urgently needed. This study introduces structure-guided changes and consensus-C-sequence-guided optimizations to generate a stabilized Glade C trimer capable of eliciting improved neutralizing and V1V2-scaffold antibodies. The results highlight the importance of the V2 region in antibody response.

CELL REPORTS (2022)

Article Immunology

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs

Nanda Kishore Routhu et al.

Summary: The study demonstrates that MVA/S vaccination induces strong neutralizing antibody and T cell responses, providing protection against SARS-CoV-2 in mice and macaques. Single-cell RNA sequencing analysis of lung cells reveals that the vaccination also protects macaques from infection-induced inflammation and B cell abnormalities.

IMMUNITY (2021)

Article Microbiology

The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection

Tysheena P. Charles et al.

Summary: This study demonstrates that neutralizing antibodies primarily targeting an exposed region on the HIV-1 envelope trimer vaccine were associated with protection, which could be achieved by a single expanding antibody family.

PLOS PATHOGENS (2021)

Review Immunology

Current approaches to HIV vaccine development: a narrative review

Jiae Kim et al.

Summary: This review summarizes the lessons learned from previous HIV vaccine efficacy trials, highlights unanswered questions, and discusses new approaches in vaccine development to address existing gaps.

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY (2021)

Review Immunology

Structure-guided envelope trimer design in HIV-1 vaccine development: a narrative review

Ronald Derking et al.

Summary: The development of an effective HIV-1 vaccine is a major challenge, requiring the induction of broadly neutralizing antibodies through the use of native-like HIV-1 envelope trimers. Progress in understanding and improving Env trimers through structural biology has been crucial for vaccine design, accelerating the iterative process and enhancing on-target antibody responses.

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY (2021)

Review Immunology

HIV vaccinology: 2021 update

Jeong Hyun Lee et al.

Summary: HIV remains a major health concern with no cure, leading to intensive research on vaccine discovery. Recent studies focus on efficacy trials and improvements in prophylactic vaccine designs for HIV.

SEMINARS IN IMMUNOLOGY (2021)

Article Immunology

Stabilized diverse HIV-1 envelope trimers for vaccine design

Qian Wang et al.

EMERGING MICROBES & INFECTIONS (2020)

Article Cell Biology

Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy

Venkateswarlu Chamcha et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Immunology

Dendritic cell subsets in T cell programming: location dictates function

S. C. Eisenbarth

NATURE REVIEWS IMMUNOLOGY (2019)

Review Immunology

Native-like Env trimers as a platform for HIV-1 vaccine design

Rogier W. Sanders et al.

IMMUNOLOGICAL REVIEWS (2017)

Article Biotechnology & Applied Microbiology

Coordinated protein co-expression in plants by harnessing the synergy between an intein and a viral 2A peptide

Bei Zhang et al.

PLANT BIOTECHNOLOGY JOURNAL (2017)

Article Multidisciplinary Sciences

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

Leopold Kong et al.

NATURE COMMUNICATIONS (2016)

Article Virology

A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype B env Gene

Pavel Pugach et al.

JOURNAL OF VIROLOGY (2015)

Article Biochemistry & Molecular Biology

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Young Do Kwon et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Multidisciplinary Sciences

Breakthrough of SIV strain smE660 challenge in SIV strain mac239-vaccinated rhesus macaques despite potent autologous neutralizing antibody responses

Samantha L. Burton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

Jean-Philippe Julien et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Young Do Kwon et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Multidisciplinary Sciences

Cryptic Determinant of alpha 4 beta 7 Binding in the V2 Loop of HIV-1 gp120

Boonrat Tassaneetrithep et al.

PLOS ONE (2014)

Article Medicine, General & Internal

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

Supachai Rerks-Ngarm et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Immunology

Impact of MHC class I diversity on immune control of immunodeficiency virus replication

Philip J. R. Goulder et al.

NATURE REVIEWS IMMUNOLOGY (2008)