4.8 Article

Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

The role of cellular senescence and SASP in tumour microenvironment

Masaki Takasugi et al.

Summary: Cellular senescence is an irreversible cell cycle arrest induced by various stresses, playing a crucial role in tumor suppression. The altered secretory profile of senescent cells contributes to the microenvironment promoting tumor development. Understanding the mechanisms underlying the diversity of the senescence-associated secretory phenotype allows the development of strategies to target senescent cells for cancer therapy effectively.

FEBS JOURNAL (2023)

Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

Article Cell Biology

The Longevity-Associated Variant of BPIFB4 Reduces Senescence in Glioma Cells and in Patients' Lymphocytes Favoring Chemotherapy Efficacy

Annibale Alessandro Puca et al.

Summary: Glioblastoma is the most common primary brain cancer, with aging being an important risk factor. Current anti-GBM therapies induce cellular senescence and the release of proinflammatory SASP factors, highlighting the need for adjuvant therapies that limit cellular senescence.
Article Cell Biology

Reciprocal regulation of p21 and Chk1 controls the cyclin D1-RB pathway to mediate senescence onset after G2 arrest

Gerald Lossaint et al.

Summary: The balance between p21 and Chk1 controls cyclin D-CDK activity during cell cycle arrest, with p21 activating RB in non-transformed cells and Chk1 maintaining its activity in cancer cells. The compromised G2 exit in cancer cells is associated with sustained Chk1 activity, delayed p21 induction, untimely cyclin E1 re-expression, and genome reduplication.

JOURNAL OF CELL SCIENCE (2022)

Article Oncology

Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses

Maximilian Rentschler et al.

Summary: Despite extensive treatment efforts, cancer remains a leading cause of death. Immunotherapy has emerged as a promising approach to combat cancer by targeting malignant cells and immune cells in the tumor microenvironment. Specific cytokines in the tumor microenvironment can induce senescence in tumor cells, which significantly affects anti-tumor responses. Unlike traditional treatments, immunotherapies primarily target cells within the tumor microenvironment, such as lymphocytes and antigen-presenting cells. Strengthening the interaction between immune cells and tumors is crucial for effective cancer control.

CANCERS (2022)

Review Oncology

Exploiting senescence for the treatment of cancer

Liqin Wang et al.

Summary: This review discusses how senescence can be induced in cancer cells and how the distinctive features of senescent cancer cells can be exploited for selective eradication. It also explores activation of the host immune system as an attractive way to clear senescent cancer cells, and the potential benefits of a sequential treatment approach with pro-senescence therapy followed by senolytic therapy.

NATURE REVIEWS CANCER (2022)

Article Oncology

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial

Francois Quenet et al.

Summary: This study aimed to evaluate the specific benefit of adding hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery compared with receiving cytoreductive surgery alone in patients with colorectal peritoneal metastases. The results showed no significant overall survival benefit after adding HIPEC, with more frequent postoperative late complications, suggesting that cytoreductive surgery alone should be prioritized as a treatment strategy.

LANCET ONCOLOGY (2021)

Review Immunology

Immunosenescence Study of T Cells: A Systematic Review

Ivon Johanna Rodriguez et al.

Summary: Aging leads to alterations in immune response, termed immunosenescence, characterized by decreased naive T cells and increased expression of CD57 and KLRG1 in memory T cells in older adults. Proinflammatory cytokines increase and telomere length decrease in old adult T cells. The heterogeneity and biases among studies hinder robust statistical analysis for identifying flow cytometry markers of T cell immunosenescence phenotype.

FRONTIERS IN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

Ines Sturmlechner et al.

Summary: The cell-cycle inhibitor p21 activates Rb-dependent transcription to generate a complex bioactive secretome, known as PASP, which includes chemokine CXCL14 that attracts macrophages. Macrophages disengage if cells normalize p21 within 4 days, but persisting p21 induction leads to M1 polarization and cytotoxic T cell response for eliminating target cells, including preneoplastic cells. Thus, p21 concurrently induces proliferative arrest and immunosurveillance of cells under duress.

SCIENCE (2021)

Review Biochemistry & Molecular Biology

CD44: A Multifunctional Mediator of Cancer Progression

Malak Hassn Mesrati et al.

Summary: CD44, a non-kinase cell surface transmembrane glycoprotein, is widely implicated as a cancer stem cell marker in multiple cancers. Cells overexpressing CD44 possess CSC traits and resistance to therapy. The CD44 gene undergoes alternative splicing, resulting in different isoforms that interact with various ligands and drive cancer-associated signaling pathways. However, the association between CD44 expression levels and clinicopathological features is contradictory, although high CD44 expression significantly contributes to tumorigenic mechanisms.

BIOMOLECULES (2021)

Article Oncology

Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy

Pataje G. Prasanna et al.

Summary: Cellular senescence is crucial in suppressing tumor growth, but radiation and chemotherapy can lead to accumulation of senescent cells in both tumor and normal tissues, potentially promoting tumor relapse and resistance to treatment. Targeting cellular senescence could be important in the fight against cancer.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Multidisciplinary Sciences

Abundant intratumoral fibrosis prevents lymphocyte infiltration into peritoneal metastases of colorectal cancer

En Wang et al.

Summary: This study investigated the organ specificities of tumor-infiltrating lymphocyte (TIL) infiltration and intratumoral fibrosis in colorectal cancer, finding that high intratumoral fibrosis in peritoneal metastases prevents T lymphocytes infiltration and may lead to treatment resistance and poor prognosis.

PLOS ONE (2021)

Review Cell Biology

Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells

Amrutha Mohan et al.

Summary: Cancer stem cells (CSCs) exhibit functional heterogeneity and hierarchical organization, giving rise to tumor-initiating cells, drug-resistant cells, or metastasis-initiating cells. Various markers are used to identify CSCs, with a combination of markers used to demarcate the heterogeneous CSCs in solid tumors.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Oncology

Senescent Cells in Cancer Therapy: Friends or Foes?

Boshi Wang et al.

TRENDS IN CANCER (2020)

Article Cell Biology

T-cell senescence contributes to abnormal glucose homeostasis in humans and mice

Hyon-Seung Yi et al.

CELL DEATH & DISEASE (2019)

Review Biochemistry & Molecular Biology

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology

Wei X. Huff et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

Article Multidisciplinary Sciences

Senescence-associated reprogramming promotes cancer stemness

Maja Milanovic et al.

NATURE (2018)

Review Oncology

Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?

R. G. Morgan et al.

BRITISH JOURNAL OF CANCER (2018)

Review Cell Biology

The Senescence-Stemness Alliance - A Cancer-Hijacked Regeneration Principle

Maja Milanovic et al.

TRENDS IN CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

Arianna Fumagalli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

To clear, or not to clear (senescent cells)? That is the question

Amaia Lujambio

BIOESSAYS (2016)

Review Biochemistry & Molecular Biology

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Bennett G. Childs et al.

NATURE MEDICINE (2015)

Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

PIK3CA and APC mutations are synergistic in the development of intestinal cancers

D. A. Deming et al.

ONCOGENE (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Oncology

Inside and out: the activities of senescence in cancer

Pedro A. Perez-Mancera et al.

NATURE REVIEWS CANCER (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Multidisciplinary Sciences

T-helper-1-cell cytokines drive cancer into senescence

Heidi Braumueller et al.

NATURE (2013)

Article Cell Biology

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Juan Carlos Acosta et al.

NATURE CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

Santhi Achuthan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Oncology

Hyperthermic intraperitoneal chemotherapy: Rationale and technique

Santiago Gonzalez-Moreno et al.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2010)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis

NE Sharpless et al.

ONCOGENE (2004)

Article Biochemistry & Molecular Biology

Reversal of human cellular senescence:: roles of the p53 and p16 pathways

CM Beauséjour et al.

EMBO JOURNAL (2003)

Article Biochemistry & Molecular Biology

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

R Edgar et al.

NUCLEIC ACIDS RESEARCH (2002)