期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.931690
关键词
inflammasome; NOD-like receptor protein 3 (NLRP3); rheumatoid arthritis; IL-1 beta; inflammation
类别
资金
- National Natural Science Foundation of China [81960296, 81871286]
- JiangXi Provincial Natural Science Foundation of China [20192ACB21006]
- Frontier Science Key Research Project of Jiangxi Provincial People's Hospital [19-008]
- Long-term (Youth) Project for Leading Innovative Talents in Jiangxi Province
- Jiangxi Provincial Clinical Research Center for Rheumatic and Immunologic Diseases [20192BCD42005]
- Jiangxi Province Medical Leading Discipline Construction Project (Rheumatology)
- Provincial and municipal joint construction projects of medical disciplines in Jiangxi Province (Rheumatology)
Rheumatoid arthritis is a chronic inflammatory disease characterized by immune system abnormalities. Recent studies suggest that NLRP3 inflammasome might play an important role in the development of rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular, symmetrical and invasive arthritis resulting from immune system abnormalities involving T and B lymphocytes. Although significant progress has been made in the understanding of RA pathogenesis, the underlying mechanisms are not fully understood. Recent studies suggest that NLRP3 inflammasome, a regulator of inflammation, might play an important role in the development of RA. There have been increasing clinical and pre-clinical evidence showing the treatment of NLRP3/IL-1 beta in inflammatory diseases. To provide a foundation for the development of therapeutic strategies, we will briefly summarize the roles of NLRP3 inflammasome in RA and explore its potential clinical treatment.
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