期刊
APPLIED SCIENCES-BASEL
卷 12, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/app12157530
关键词
3D printing; modeling simulation; chitosan hydrogel; extrusion 3D printing
类别
资金
- National Key Research and Development program of China [2018YFA0703000]
- science Fund for Creative Research Groups of the National Natural Science Foundation of China [51521064]
This study used multiphysics simulation to predict the printability of chitosan hydrogel in extrusion-based 3D printing. The impact of different velocities and viscosities was investigated, and the model validation confirmed the high-quality printing outcomes. The results provide information for determining the optimum parameters for printing chitosan-based ink with high quality.
Extrusion-based three-dimensional (3D) printing has recently become a major field that provides significant benefits, as it is principally employed to fabricate 3D scaffolds, exploiting soft biomaterials. The 3D printing hydrogel-based ink requires crucial properties, such as printability and printing fidelity to fabricate the appropriate structure. However, it typically uses trial and error techniques to achieve a three-dimensional structure, which wastes material and time. This study employed multiphysics simulation to predicate the potential printability of chitosan hydrogel as a desirable biomaterial used in tissue engineering. The flow was presumed to be laminar and two-phased in the simulations. Furthermore, the impact of different velocities and viscosities in extrusion-based chitosan 3D printing was investigated. Moreover, the model validation of the printed chitosan hydrogel was investigated to confirm the simulation outcomes for high-quality printing. The effect of different printing settings was studied during the experimental test. The results obtained from the simulation and experiments provide information for deciding the optimum parameters for printing chitosan-based ink with high quality.
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