☆ 4.6 Review

Nanomaterials in Bone Regeneration

APPLIED SCIENCES-BASEL (2022)

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Review Chemistry, Inorganic & Nuclear

Biomedical Applications of Functionalized Gold Nanoparticles: A Review

Kazem Nejati et al.

Summary: Metal nanoparticles, especially gold nanoparticles, have unique physicochemical properties that make them valuable for biomedical applications such as biosensing, cancer therapy, and drug delivery. Their large surface area allows for functionalization with biological molecules, making them a promising carrier for targeted drug delivery.

JOURNAL OF CLUSTER SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Green one-step synthesis of silver nanoparticles and their biosafety and antibacterial properties

Xueling Cao et al.

Summary: Silver nanoparticles with antibacterial properties were synthesized using a one-step method, with environmentally friendly reagents and no need for subsequent purification. The structure and antibacterial properties of the nanoparticles were investigated and characterized, showing good antibacterial activity and biosafety.

GREEN CHEMISTRY LETTERS AND REVIEWS (2022)

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Article Chemistry, Multidisciplinary

Ferrimagnetic Large Single Domain Iron Oxide Nanoparticles for Hyperthermia Applications

Diana Zahn et al.

Summary: This paper describes the preparation and magnetic properties of large single domain iron oxide nanoparticles. The particles exhibit single domain ferrimagnetic behavior and their properties are size-dependent. Additionally, the particles show promising potential for magnetic hyperthermia applications.

NANOMATERIALS (2022)

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Review Biotechnology & Applied Microbiology

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

Duraipandy Natarajan et al.

Summary: The challenges in bone graft and prosthetic implant designing for clinical application are being addressed with the revolutionary advances of nanotechnology, particularly in the use of rare earth (RE) materials with unique properties for tissue engineering. Researchers have developed smart nano-biomaterials using RE materials for bone tissue engineering and implantology applications, exploring their molecular mechanisms and potential for novel strategies. The biomedical applications of micro or nano-scale RE materials have shown promise in providing cost-effective solutions in bone tissue engineering.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Synergistic sorption performance of karaya gum crosslink poly (acrylamide-co-acrylonitrile) @ metal nanoparticle for organic pollutants

Sadanand Pandey et al.

Summary: In this study, facile hydrogels nanocomposite (HNC) based on sustainable karaya gum were prepared for water treatment. The HNC exhibited high adsorption capacity for crystal violet (CV) dye removal and could be regenerated for multiple reuse. The loading of silver nanoparticles (AgNPs) into the polymeric matrix significantly enhanced the removal percentage of CV dye.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Polymer Science

Silver, Copper, Magnesium and Zinc Contained Electroactive Mesoporous Bioactive S53P4 Glass-Ceramics Nanoparticle for Bone Regeneration: Bioactivity, Biocompatibility and Antibacterial Activity

A. Kumar et al.

Summary: This study investigated the properties of therapeutic ions doped mesoporous S53P4 electroactive glass-ceramics nanoparticles for bone regeneration. The results showed that the doped MGCs exhibited good electrical property and in vitro bioactivity, and had no significant cytotoxic effects on cells.

JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS (2022)

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Article Chemistry, Physical

Synthesis and characterization of Cu2Zn1.75Mo3O12 ceramic nanoparticles with excellent antibacterial property

Fatemeh Karkeh-Abadi et al.

Summary: This study introduces Cu2Zn1.75Mo3O12 nanoparticles as an effective antibacterial agent for the first time. The nanoparticles were prepared using the ultrasonic method and their structural and morphological properties were investigated. The results show that Cu2Zn1.75Mo3O12 nanoparticles have remarkable antibacterial properties, attributed to the presence of zinc which improves the photocatalytic and ion release mechanisms.

JOURNAL OF MOLECULAR LIQUIDS (2022)

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Article Endocrinology & Metabolism

Low serum osteocalcin levels are associated with diabetes mellitus in glucocorticoid treated patients

H. Florez et al.

Summary: Bone turnover markers are decreased in GC-treated subjects with diabetes mellitus (DM), with reduced OC levels associated with increased DM risk. Among these markers, only OC was independently associated with the presence of DM in GC-treated patients.

OSTEOPOROSIS INTERNATIONAL (2022)

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Review Chemistry, Multidisciplinary

Current Methods in the Study of Nanomaterials for Bone Regeneration

Manabu Tanaka et al.

Summary: Nanomaterials have great potential for bone regeneration and can be used as fillers or carriers. Currently, the evaluation of bone regeneration materials heavily relies on animal experiments, which should be minimized. This review introduces an in vitro strategy for evaluating these materials and discusses the caveats encountered in nanomaterial research. The development of versatile assessment methods for biomaterial development is anticipated.

NANOMATERIALS (2022)

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Article Biotechnology & Applied Microbiology

Fabrication of In Situ Grown Hydroxyapatite Nanoparticles Modified Porous Polyetheretherketone Matrix Composites to Promote Osteointegration and Enhance Bone Repair

Ningning Wang et al.

Summary: In this study, nanohydroxyapatite-doped porous polyetheretherketone materials were successfully fabricated, and both in vitro and in vivo experiments demonstrated their ability to promote bone regeneration and osteointegration.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Chemistry, Applied

Chitosan nanocarriers for microRNA delivery and detection: A preliminary review with emphasis on cancer

Saman Sargazi et al.

Summary: In recent years, gene therapy based on miRNA has emerged as a potential technique for treating co-morbidities. Chitosan, as an effective carrier for miRNA delivery, has been widely utilized. This review discusses the recent progress and future prospects of using chitosan and its derivatives to deliver and detect miRNAs, with a focus on cancer.

CARBOHYDRATE POLYMERS (2022)

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Article Chemistry, Physical

Radioactive organic semiconducting polymer nanoparticles for multimodal cancer theranostics

Ningyue Yu et al.

Summary: This study reports the development of radioactive semiconducting polymer nanoparticles (rSPNs) for multimodal cancer theranostics. The rSPNs, constructed by labeling poly (ethylene glycol) (PEG) grafted SPNs with iodine-131 (I-131), demonstrate ideal photothermal property, excellent singlet oxygen generating ability, and good radiolabeling stability. With their small particle size and PEG surface corona, rSPNs effectively accumulate in subcutaneous tumors after systemic administration in living mice. The fluorescence property and stable radiolabeling of rSPNs enable contrast signals for near-infrared (NIR) fluorescence and single photon emission computed tomography (SPECT) dual-model imaging of tumors. Furthermore, rSPNs exhibit combinational action of photothermal therapy (PTT), photodynamic therapy (PDT), and radiotherapy under NIR laser irradiation, resulting in higher therapeutic efficacy compared to SPNs-mediated treatment.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Materials Science, Characterization & Testing

Preparation of osteoinductive - Antimicrobial nanocomposite scaffolds based on poly (D,L-lactide-co-glycolide) modified with copper - Doped bioactive glass nanoparticles

Cristian Covarrubias et al.

Summary: This study explored the preparation of porous nanocomposite scaffolds with simultaneous osteogenic and antibacterial properties by incorporating copper-doped bioactive glass nanoparticles. The copper-doped nanoparticles promoted bone mineralization and osteogenic differentiation of stem cells. However, the antibacterial activity of the nanocomposite scaffolds was not significantly superior to that of the pure polymer scaffold.

POLYMERS & POLYMER COMPOSITES (2022)

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Article Nutrition & Dietetics

Relationship Between Chronic Kidney Disease, Glucose Homeostasis, and Plasma Osteocalcin Carboxylation and Fragmentation

Mario Kratz et al.

Summary: In chronic kidney disease (CKD) patients, circulating osteocalcin concentrations are elevated, partly due to increased proportions of fragmented forms. However, osteocalcin carboxylation status does not significantly differ between individuals with and without CKD. The data also do not support the hypothesis that differences in osteocalcin carboxylation may explain reduced insulin sensitivity in individuals with CKD.

JOURNAL OF RENAL NUTRITION (2021)

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Article Nanoscience & Nanotechnology

Gold Nanoparticles Promote the Bone Regeneration of Periodontal Ligament Stem Cell Sheets Through Activation of Autophagy

Yangheng Zhang et al.

Summary: The study showed that AuNPs can enhance osteogenesis of PDLSC sheets by promoting bone-related protein expression and mineralization, with 45-nm AuNPs being more effective than 13-nm ones. Additionally, AuNPs were found to activate the autophagy pathway to promote differentiation and enhance bone regeneration in ectopic models. These findings suggest a potential AuNP-based pretreatment strategy for improving CST in bone repair and regeneration.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Materials Science, Multidisciplinary

Silica nanoparticles-incorporated carbon nanofibers as bioactive biomaterial for bone tissue engineering

Houra Nekounam et al.

Summary: This study fabricated different ECNFs/SNPs composites via electrospinning and thermal treatments, and evaluated the effect of SNPs incorporation on the properties of ECNFs. The results showed that the incorporation of SNPs can improve the cell attachment, viability, and proliferation rate of the materials.

DIAMOND AND RELATED MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Phytomolecules-Coated NiO Nanoparticles Synthesis Using Abutilon indicum Leaf Extract: Antioxidant, Antibacterial, and Anticancer Activities

Shakeel Ahmad Khan et al.

Summary: NiO nanoparticles coated with plant molecules synthesized using plant extract demonstrated superior antibacterial and anticancer performance, excellent antioxidant activity, and biocompatibility.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Chemistry, Multidisciplinary

Local and Systemic In Vivo Responses to Osseointegrative Titanium Nanotube Surfaces

Erin A. Baker et al.

Summary: The study characterized the effects of different TiNT surface morphologies on rat bone marrow cell attachment and overall response, showing that TiNT surfaces can promote osseointegration and have no significant differences in body and blood parameters in rats. However, the trabecular TiNT group had higher aluminum levels in the lungs compared to controls.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Nano-Based Biomaterials as Drug Delivery Systems Against Osteoporosis: A Systematic Review of Preclinical and Clinical Evidence

Francesca Salamanna et al.

Summary: Osteoporosis is a significant cause of morbidity, especially in post-menopausal women and older men, but the search for an effective treatment remains a challenge. Despite the progress in developing nano-based materials as drug delivery systems against OP, further clinical investigations and evaluation are necessary. Some main challenges include low reproducibility in manufacturing processes, unsatisfactory drug-loading capacity, uncontrollable release kinetics, and low delivery efficiency, which limit the clinical application of these materials.

NANOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles

Sharlee L. More et al.

Summary: Nickel nanomaterials have exceptional physical and chemical properties, which have been utilized in various applications, but may also pose potential adverse health effects. This review critically evaluates the toxicity data of oxidic nickel nanoparticles, emphasizing physico-chemistry properties, model system appropriateness, biodistribution, and exposure routes. Future studies are needed to better understand the dose-response relationship and potential biological responses of nickel nanomaterials.

NANOMATERIALS (2021)

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Article Multidisciplinary Sciences

Undercarboxylated osteocalcin inhibits the early differentiation of osteoclast mediated by Gprc6a

Hailong Wang et al.

Summary: Our study demonstrated that ucOCN negatively affected the early differentiation and bone resorption of osteoclasts through the Gprc6a receptor. The inhibitory effects of ucOCN on osteoclasts were mainly observed at the early stage of osteoclastogenesis. Signaling analysis suggested that Gprc6a receptor played a crucial role in mediating the effects of ucOCN.

PEERJ (2021)

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Article Anatomy & Morphology

Bone tissue and histological and molecular events during development of the long bones

Michael J. F. Blumer

Summary: Bones are crucial for vertebrate locomotion and organ protection, developing through intricate processes like intramembranous and endochondral ossification. These two modes of bone formation play a key role in the establishment of the skeletal system.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2021)

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Review Endocrinology & Metabolism

Broadening the role of osteocalcin in the hypothalamic-pituitary-gonadal axis

Chang Shan et al.

Summary: Bones are now seen as an important endocrine organ, with osteocalcin playing a crucial role in influencing insulin secretion, glucose and lipid metabolism, testosterone biosynthesis, and male fertility. However, the detailed functional mechanisms of osteocalcin on the hypothalamic-pituitary-gonadal axis or the pancreas-bone-gonadal axis are not fully understood.

JOURNAL OF ENDOCRINOLOGY (2021)

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Article Materials Science, Biomaterials

Multi-functional cerium oxide nanoparticles regulate inflammation and enhance osteogenesis

Fei Wei et al.

Summary: Cerium oxide nanoparticles exhibit beneficial effects on bone-related cells and cytokine expression under both acute and chronic inflammatory conditions, but do not promote osteogenic differentiation or mineral deposition.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Chemistry, Physical

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

Gan Huang et al.

Summary: Porous tantalum (Ta) possesses excellent biological and mechanical properties that promote bone growth and implant stability. With the advancement of additive manufacturing, personalized porous Ta-based implants or prostheses have demonstrated significant clinical value in treatment.

MATERIALS (2021)

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Article Chemistry, Physical

Beneficial Influence of Water-Soluble PEG-Functionalized C60 Fullerene on Human Osteoblast Growth In Vitro

Piotr Piotrowski et al.

Summary: The study found that the new PEG-functionalized C-60 fullerene derivative has good solubility in water, high temperature stability, and no cytotoxic effect on cells, which promotes osteoblast proliferation.

MATERIALS (2021)

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Article Engineering, Biomedical

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway

Chunxia Ren et al.

Summary: Metformin carbon dots (MCDs) prepared in this study showed excellent biocompatibility and enhanced osteogenic activity more effectively under inflammatory conditions compared to metformin. MCDs also demonstrated promising potential for regenerating lost alveolar bone in periodontitis rat model, indicating a novel nanomaterial for periodontitis treatment with potential pharmacological targets.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Novel Inorganic Nanomaterial-Based Therapy for Bone Tissue Regeneration

Yu Fu et al.

Summary: Repairing extensive bone defects remains a challenge in clinical settings, and inorganic nanomaterials such as nano hydroxyapatites, nano silica, and metallic nanomaterials offer unique advantages in enhancing biocompatibility and biological activity to support bone regeneration. Through processes like biosilica mineralization and the mechanical properties of metallic nanomaterials, these materials can facilitate bone structure repair and strengthen, laying the foundation for novel bone regeneration strategies.

NANOMATERIALS (2021)

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Review Oncology

Nanotechnology in Bladder Cancer: Diagnosis and Treatment

Mahmood Barani et al.

Summary: Bladder cancer is a common cancer in both men and women, and the use of nanotechnology has shown promising potential in improving the diagnosis and treatment of this disease. Nanoparticles offer a novel approach to enhance drug delivery and therapeutic performance, reducing the limitations of conventional cancer therapies. Developing nanosystems that can effectively diagnose and treat bladder cancer is crucial in advancing medical approaches in cancer management.

CANCERS (2021)

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Article Biology

Composite Scaffolds for Bone Tissue Regeneration Based on PCL and Mg-Containing Bioactive Glasses

Mauro Petretta et al.

Summary: In this study, 3D-printed PCL scaffolds reinforced with Mg-doped bioactive glass were developed, showing improved mechanical properties and biological reactivity for bone tissue engineering applications. The composite scaffolds demonstrated high biocompatibility, bioactivity, and cell adhesion, making them promising for promoting cell viability and supporting mechanical loading in trabecular bone.

BIOLOGY-BASEL (2021)

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Review Biochemistry & Molecular Biology

A Review on Green Synthesis, Characterization and Anticancer Application of Metallic Nanoparticles

Piyush Kumar Thakur et al.

Summary: Cancer is a major cause of mortality worldwide, with challenges in clinical management due to side effects of traditional treatment. Nanotechnology shows promise in improving cancer treatment and drug development, offering potential for enhancing quality of life for humans.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Overview on green synthesis of metallic nanoparticles

Pranali Kurhade et al.

Summary: Nanotechnology offers advanced solutions to modern issues, allowing for more sustainable products and processes. Green synthesis of metal nanoparticles is non-toxic, high-yield, and influenced by the diverse chemical components of biological extracts. This method shows potential applications across various fields and demonstrates a unique sustainability impact over the environment.

CHEMICAL PAPERS (2021)

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Review Biochemistry & Molecular Biology

Vitamin K-Dependent Proteins in Skeletal Development and Disease

Michael Stock et al.

Summary: Vitamin K and Vitamin K-dependent proteins play crucial roles in blood coagulation and are also important in skeletal biology and diseases. These proteins have diverse roles in controlling calcification and turnover in bone and cartilage.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

In Situ Hydroxyapatite Synthesis Enhances Biocompatibility of PVA/HA Hydrogels

Petra Chocholata et al.

Summary: Bone tissue engineering aims to mimic the natural behavior of hard tissues. This study found that scaffolds with in situ synthesized hydroxyapatite (HAp) showed better proliferation of human osteoblast-like cells than those with physically mixed pre-prepared HAp, indicating the advantages of in situ synthesizing HAp directly in the organic matrix to improve scaffold properties.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Engineering, Biomedical

Green electrospinning for biomaterials and biofabrication

Christopher Z. Mosher et al.

Summary: This study introduced a green electrospinning technique that utilized environmentally benign acetic acid as a solvent to update the fabrication of various biomaterials. The resulting green fibers and composites exhibited properties comparable to traditional meshes but with improved biomimicry.

BIOFABRICATION (2021)

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Article Chemistry, Physical

Nanostructured Surfaces to Promote Osteoblast Proliferation and Minimize Bacterial Adhesion on Titanium

Samira Esteves Afonso Camargo et al.

Summary: The study found that titanium nanotubes promoted the proliferation of human osteoblasts and reduced biofilm adhesion. The presence of silicon carbide also had an effect on the nanostructured surfaces.

MATERIALS (2021)

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Review Materials Science, Multidisciplinary

Metallic Nanoscaffolds as Osteogenic Promoters: Advances, Challenges and Scope

Sougata Ghosh et al.

Summary: This review explores advances in nanotechnology driven solutions for bone tissue engineering, discussing the fabrication of osteogenic scaffolds using metals and polymeric bases with tunable physico-chemical properties. It also mentions future directions for incorporating bioceramics, biogenic nanoparticles, and fourth generation biomaterials to enhance biocompatibility and mechanical properties in orthopedic applications, potentially revolutionizing the future of orthopedics.

METALS (2021)

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Review Orthopedics

Copper-based biomaterials for bone and cartilage tissue engineering

Yufeng Wang et al.

Summary: Copper-based biomaterials have been increasingly used in tissue engineering for bone and cartilage repair, providing unique properties that enhance biological functions such as cell migration, adhesion, osteogenesis, chondrogenesis, angiogenesis, and antibacterial activities.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2021)

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Review Materials Science, Biomaterials

Application of nanoparticles in bone tissue engineering; a review on the molecular mechanisms driving osteogenesis

Azam Bozorgi et al.

Summary: Nanoparticles play a significant role in advancing osteogenesis by regulating cellular and molecular pathways and creating an osteogenic niche. They enhance scaffold-free and scaffold-based tissue engineering strategies to promote bone regeneration, but more considerations are needed for their clinical applications due to potential toxicities.

BIOMATERIALS SCIENCE (2021)

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Article Biotechnology & Applied Microbiology

Biodegradable zinc oxide composite scaffolds promote osteochondral differentiation of mesenchymal stem cells

Ateka Khader et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

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Article Materials Science, Ceramics

Enhanced bone regeneration of 3D printed β-Ca2SiO4 scaffolds by aluminum ions solid solution

Bin Yu et al.

CERAMICS INTERNATIONAL (2020)

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Review Engineering, Electrical & Electronic

Nanomanufacturing of biopolymers using electron and ion beams

Jianjuan Jiang et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2020)

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Article Biotechnology & Applied Microbiology

Silver nanoparticles stimulate osteogenesis of human mesenchymal stem cells through activation of autophagy

Wei He et al.

NANOMEDICINE (2020)

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Article Spectroscopy

Determining elemental strontium distribution in rat bones treated with strontium ranelate and strontium citrate using 2D micro-XRF and 3D dual energy K-edge subtraction synchrotron imaging

Daniel Cardenas et al.

X-RAY SPECTROMETRY (2020)

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Article Chemistry, Physical

Fabrication of palladium nanoparticles anchored polypyrrole functionalized reduced graphene oxide nanocomposite for antibiofilm associated orthopedic tissue engineering

Murugesan Balaji et al.

APPLIED SURFACE SCIENCE (2020)

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Review Chemistry, Multidisciplinary

Cell-Inspired All-Aqueous Microfluidics: From Intracellular Liquid-Liquid Phase Separation toward Advanced Biomaterials

Qingming Ma et al.

ADVANCED SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Cytotoxicity, Oxidative Stress, and Autophagy Effects of Tantalum Nanoparticles on MC3T3-E1 Mouse Osteoblasts

Peihuan Wang et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2020)

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Article Polymer Science

3D Hierarchical, Nanostructured Chitosan/PLA/HA Scaffolds Doped with TiO2/Au/Pt NPs with Tunable Properties for Guided Bone Tissue Engineering

Julia Radwan-Praglowska et al.

POLYMERS (2020)

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Review Pharmacology & Pharmacy

The Bone Extracellular Matrix in Bone Formation and Regeneration

Xiao Lin et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Chemistry, Multidisciplinary

The Use of Electrospun Organic and Carbon Nanofibers in Bone Regeneration

Kaoru Aoki et al.

NANOMATERIALS (2020)

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Review Chemistry, Multidisciplinary

Protein-based Smart Microtubes and Nanotubes as Ultrasmall Biomaterials

Teruyuki Komatsu

CHEMISTRY LETTERS (2020)

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Article Chemistry, Multidisciplinary

Biofabrication of gold nanoparticles with bone remodeling potential: an in vitro and in vivo assessment

Sneha Singh et al.

JOURNAL OF NANOPARTICLE RESEARCH (2020)

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Article Engineering, Chemical

In-vivo study of ultrafine-grained CP-Ti dental implants surface modified by SLActive with excellent wettability

Milad Masrouri et al.

INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES (2020)

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Review Nanoscience & Nanotechnology

The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics

Hongru Li et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Nanoscience & Nanotechnology

Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review

Yuehong Li et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Engineering, Biomedical

3D construct of hydroxyapatite/zinc oxide/palladium nanocomposite scaffold for bone tissue engineering

Fatemeh Heidari et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2020)

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Review Cell & Tissue Engineering

Metal-based nanoparticles for bone tissue engineering

Reza Eivazzadeh-Keihan et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2020)

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Article Materials Science, Biomaterials

Improved osteogenesis and angiogenesis of a novel copper ions doped calcium phosphate cement

Zefeng Lin et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Polymer Science

Mechanical and Antimicrobial Polyethylene Composites with CaO Nanoparticles

Cristian Silva et al.

POLYMERS (2020)

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Review Chemistry, Multidisciplinary

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

Pawan Kumar et al.

NANOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Icariin-Functionalized Nanodiamonds to Enhance Osteogenic Capacity In Vitro

Somang Choi et al.

NANOMATERIALS (2020)

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Article Materials Science, Biomaterials

Stable and Antibacterial Magnesium-Graphene Nanocomposite-Based Implants for Bone Repair

Narges Safari et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Biotechnology & Applied Microbiology

Nanostructured Biomaterials for Bone Regeneration

Joseph G. Lyons et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Materials Science, Biomaterials

Au, Pd and maghemite nanofunctionalized hydroxyapatite scaffolds for bone regeneration

Giovanna Calabrese et al.

REGENERATIVE BIOMATERIALS (2020)

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Article Cell Biology

Investigation of Cytotoxicity, Oxidative Stress, and Inflammatory Responses of Tantalum Nanoparticles in THP-1-Derived Macrophages

Li Zhang et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Engineering, Biomedical

Nanoparticle technology and its implications in endodontics: a review

Natasha Raura et al.

BIOMATERIALS RESEARCH (2020)

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Article Nanoscience & Nanotechnology

Nano-Silicate-Reinforced and SDF-1α-Loaded Gelatin-Methacryloyl Hydrogel for Bone Tissue Engineering

Zhe Shi et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Materials Science, Biomaterials

Gelatin-alginate-cerium oxide nanocomposite scaffold for bone regeneration

Shiv Dutt Purohit et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Materials Science, Biomaterials

Osteopromotive carbon dots promote bone regeneration through the PERK-eIF2α-ATF4 pathway

Nianqiang Jin et al.

BIOMATERIALS SCIENCE (2020)

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Review Engineering, Multidisciplinary

Metal Oxide Nanoparticles as Biomedical Materials

Maria P. Nikolova et al.

BIOMIMETICS (2020)

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Review Medicine, Research & Experimental

Silver nanoparticles: Synthesis, medical applications and biosafety

Li Xu et al.

THERANOSTICS (2020)

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Article Biochemistry & Molecular Biology

Ceria nanoparticles enhance endochondral ossification-based critical-sized bone defect regeneration by promoting the hypertrophic differentiation of BMSCs via DHX15 activation

Jianmei Li et al.

FASEB JOURNAL (2019)

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Article Materials Science, Biomaterials

Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation

Hao Zhu et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Biotechnology & Applied Microbiology

Advances in green synthesis of nanoparticles

Aman Gour et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Article Nanoscience & Nanotechnology

Mechanically Strong Silica-Silk Fibroin Bioaerogel: A Hybrid Scaffold with Ordered Honeycomb Micromorphology and Multiscale Porosity for Bone Regeneration

Hajar Maleki et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Allergy

Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

Malin G. Ahlstrom et al.

CONTACT DERMATITIS (2019)

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Article Chemistry, Physical

Near-Infrared Light-Triggered Porous AuPd Alloy Nanoparticles To Produce Mild Localized Heat To Accelerate Bone Regeneration

Xingang Zhang et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2019)

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Article Chemistry, Analytical

Green synthesis of strontium nanoparticles self-assembled in the presence of carboxymethyl cellulose: an in vivo imaging study

Hojjat Samareh Fekri et al.

LUMINESCENCE (2019)

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Article Materials Science, Biomaterials

Fabrication and characterization of biomimetic hydroxyapatite thin films for bone implants by direct ablation of a biogenic source

Gabriela Graziani et al.

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Article Chemistry, Physical

Femtosecond Laser Nano/Micro Textured Ti6Al4V Surfaces-Effect on Wetting and MG-63 Cell Adhesion

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Article Chemistry, Physical

Metal Nanoparticles Released from Dental Implant Surfaces: Potential Contribution to Chronic Inflammation and Peri-Implant Bone Loss

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An Injectable Strong Hydrogel for Bone Reconstruction

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NANOMATERIALS (2019)

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Surface treatments on titanium implants via nanostructured ceria for antibacterial and anti-inflammatory capabilities

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Effect of Strontium and Magnesium Additions on the Microstructure and Mechanical Properties of Al-12Si Alloys

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METALS AND MATERIALS INTERNATIONAL (2019)

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Morphometry Results of Formed Osteodefects When Using Nanocrystalline CeO2 in the Early Stages of Regeneration

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INTERNATIONAL JOURNAL OF DENTISTRY (2019)

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Evaluation of Mechanical Properties and Cell Viability of Poly (3-Hydroxybutyrate)-Chitosan/Al2O3 Nanocomposite Scaffold for Cartilage Tissue Engineering

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A genomic characterization of the influence of silver nanoparticles on bone differentiation in MC3T3-E1 cells

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Injectable nanosilica-chitosan microparticles for bone regeneration applications

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Strontium-Doped Bioactive Glass Nanoparticles in Osteogenic Commitment

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Versatile effects of magnesium hydroxide nanoparticles in PLGA scaffold-mediated chondrogenesis

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Promoting in vivo early angiogenesis with sub-micrometer strontium-contained bioactive microspheres through modulating macrophage phenotypes

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Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

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The bone remodelling cycle

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ANNALS OF CLINICAL BIOCHEMISTRY (2018)

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Role of osteopontin in bone remodeling and orthodontic tooth movement: a review

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PROGRESS IN ORTHODONTICS (2018)

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Nanoparticles in tissue engineering: applications, challenges and prospects

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Proliferation of Osteoblasts on Laser-Modified Nanostructured Titanium Surfaces

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Combined effect of grain refinement and surface modification of pure titanium on the attachment of mesenchymal stem cells and osteoblast-like SaOS-2 cells

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Optimized composition of nanocomposite scaffolds formed from silk fibroin and nano-TiO2 for bone tissue engineering

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Corrosion and surface modification on biocompatible metals: A review

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Osteogenic differentiation of bone marrow mesenchymal stem cells by magnetic nanoparticle composite scaffolds under a pulsed electromagnetic field

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Size-dependent Effects of Gold Nanoparticles on Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells

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The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration

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Modification of the Surface Topography and Composition of Ultrafine and Coarse Grained Titanium by Chemical Etching

Denis V. Nazarov et al.

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Micro-Arc Oxidation Enhances the Blood Compatibility of Ultrafine-Grained Pure Titanium

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Nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration

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Synthesis and characterization of CaO-loaded electrospun matrices for bone tissue engineering

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Strategic role of selected noble metal nanoparticles in medicine

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Multiwall carbon nanotubes/polycaprolactone scaffolds seeded with human dental pulp stem cells for bone tissue regeneration

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Fe3O4/BSA particles induce osteogenic differentiation of mesenchymal stem cells under static magnetic field

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ACTA BIOMATERIALIA (2016)

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Concentration-dependent behaviors of bone marrow derived mesenchymal stem cells and infectious bacteria toward magnesium oxide nanoparticles

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ACTA BIOMATERIALIA (2016)

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Femto second laser surface texturing of titanium as a method to reduce the adhesion of Staphylococcus aureus and biofilm formation

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Magnetic nanocomposite scaffolds combined with static magnetic field in the stimulation of osteoblastic differentiation and bone formation

Hyung-Mun Yun et al.

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New insights into the biology of osteocalcin

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Sodium alginate stabilized silver nanoparticles-silica nanohybrid and their antibacterial characteristics

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Smart nickel oxide based core-shell nanoparticles for combined chemo and photodynamic cancer therapy

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Preparation of bone-implants by coating hydroxyapatite nanoparticles on self-formed titanium dioxide thin-layers on titanium metal surfaces

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Enhanced osteointegration on tantalum-implanted polyetheretherketone surface with bone-like elastic modulus

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Evaluation of polyphenols as possible therapeutics for amyloidoses: Comparative analysis of Kaempferol and Catechin

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Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway

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Silica-based mesoporous nanobiomaterials as promoter of bone regeneration process

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Comparison of Fibroblast and Osteoblast Response to Cultivation on Titanium Implants with Different Grain Sizes

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Silver nanoparticles promote osteogenesis of mesenchymal stem cells and improve bone fracture healing in osteogenesis mechanism mouse model

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Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases

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Surface Modifications and Their Effects on Titanium Dental Implants

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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

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Incorporation of copper into chitosan scaffolds promotes bone regeneration in rat calvarial defects

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CHEMICAL REVIEWS (2014)

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Effect of doping in carbon nanotubes on the viability of biomimetic chitosan-carbon nanotubes-hydroxyapatite scaffolds

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Enhanced bone regeneration with a gold nanoparticle-hydrogel complex

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Nanotechnology based approaches in cancer therapeutics

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Protein-Protein Nanoimprinting of Silk Fibroin Films

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Growth and Potential Damage of Human Bone-Derived Cells on Fresh and Aged Fullerene C60 Films

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Electrospinning of polymer nanofibers loaded with noncovalently functionalized graphene

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Comparative study of membranotropic action of single- and multi-walled carbon nanotubes

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Multi-protein Delivery by Nanodiamonds Promotes Bone Formation

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Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells

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Preparation, mechanical properties and biocompatibility of graphene oxide/ultrahigh molecular weight polyethylene composites

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Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis

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Influence of the fetal bovine serum proteins on the growth of human osteoblast cells on graphene

Marie Kalbacova et al.

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Antimicrobial acrylic materials with in situ generated silver nanoparticles

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Stimulation of Minerals by Carbon Nanotube Grafted Glucosamine in Mouse Mesenchymal Stem Cells for Bone Tissue Engineering

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Accelerated stem cell attachment to ultrafine grained titanium

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The generation of biomolecular patterns in highly porous collagen-GAG scaffolds using direct photolithography

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Ionized calcium

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Advances in bone repair with nanobiomaterials: mini-review

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Electrospun poly (lactic-co-glycolic acid)/multiwalled carbon nanotubes composite scaffolds for guided bone tissue regeneration

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The Effects of Replacing Collagen Fibers with Carbon Nanotubes on the Rate of Bone Remodeling Process

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Nanodiamond as a Vector for siRNA Delivery to Ewing Sarcoma Cells

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Gold Nanoparticles Promote Osteogenic Differentiation of Mesenchymal Stem Cells through p38 MAPK Pathway

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Regulation of gene expression in osteoblasts

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Fullerenol-Cytotoxic Conjugates for Cancer Chemotherapy

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BioglassA®-based scaffolds with carbon nanotube coating for bone tissue engineering

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Nanodiamond as Promising Material for Bone Tissue Engineering

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Normal Bone Anatomy and Physiology

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Affective Disorders, Bone Metabolism, and Osteoporosis

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CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM (2008)

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Differential biocompatibility of carbon nanotubes and nanodiamonds

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Improved biological characteristics of poly(L-lactic acid) electrospun membrane by incorporation of multiwalled carbon nanotubes/hydroxyapatite nanoparticles

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Improved adhesion and growth of human osteoblast-like MG 63 cells on biomaterials modified with carbon nanoparticles

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Characterization of antibacterial nanoparticles froin the scallop, Ptinopecten yessoensis

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Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers

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Effects of strontium and titanium on the microstructure, tensile properties and creep behavior of AM50 alloys

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Oligonucleotide-modified gold nanoparticles for intracellular gene regulation

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Bactericidal effects of CaO (scallop-shell powder) on foodborne pathogenic bacteria

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Nanofibers and their applications in tissue engineering

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Gas-phase synthesis of nitrogen-doped TiO2 nanorods by microwave plasma torch at atmospheric pressure -: art. no. 114501

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PHYSICS OF PLASMAS (2005)

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Article Chemistry, Physical

A bone mimic based on the self-assembly of hydroxyapatite on chemically functionalized single-walled carbon nanotubes

B Zhao et al.

CHEMISTRY OF MATERIALS (2005)

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Wnt/β-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

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DEVELOPMENTAL CELL (2005)

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Matrix remodeling during endochondral ossification

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TRENDS IN CELL BIOLOGY (2004)

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Developmental regulation of the growth plate

HM Kronenberg

NATURE (2003)

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Bone matrix proteins: their function, regulation, and relationship to osteoporosis

MF Young

OSTEOPOROSIS INTERNATIONAL (2003)

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Reaching a genetic and molecular understanding of skeletal development

G Karsenty et al.

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The transcription factors L-sox5 and sox6 are essential for cartilage formation

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Antimycobacterial activity of ionic fullerene derivatives

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)

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Effect of mechanical surface pretreatment on metal ion release

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