期刊
APPLIED SCIENCES-BASEL
卷 12, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/app12157779
关键词
Betti reaction; antitumor activity; neuroblastoma; adenocarcinoma
Two aminobenzylnaphthols, synthesized with the Betti reaction, were investigated as antiproliferative agents against adenocarcinoma human colorectal (Caco-2) and human neuroblastoma (SH-SY5Y) cell lines. One molecule showed better antiproliferative activity after 24 hours of incubation, while the other was more effective after 72 hours. These results suggest that both compounds have potential biological activity.
Two aminobenzylnaphthols, which are representative items of the family of compounds synthesized with the Betti reaction, were investigated as antiproliferative agents against adenocarcinoma human colorectal (Caco-2) and human neuroblastoma (SH-SY5Y) cell lines, using cisplatin as a positive control. A better antiproliferative activity was recorded after 24 h of incubation for the first tested molecule, whereas the other one was more effective after 72 h of incubation. These results support the hypothesis that both of the tested aminobenzylnaphthols could potentially be endowed with a biological activity.
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