Third-Generation Sequencing in Clinical Practice: The New Era of Precision Medicine?

In the last decades, the spreading of next-generation sequencing (NGS) in clinical practice has considerably increased the genomic knowledge of several disorders. The recent advent of third-generation sequencing is transforming the standard way of conceiving clinical genomics, overcom-ing the main limits of conventional NGS technologies and achieving challenges so far considered unreasonable. What was impracticable only a few years ago, in terms of potential and affordability, now is becoming achievable. The new sequencing era will improve diagnostic and therapeutic ap-proaches, providing clinicians with valid support in their practice.

Automated summary

The widespread adoption of next-generation sequencing (NGS) in clinical practice has significantly expanded the understanding of various disorders at the genomic level. The recent introduction of third-generation sequencing has revolutionized the field of clinical genomics by overcoming the limitations of conventional NGS technologies and achieving previously perceived as unattainable. What was once impractical in terms of potential and affordability has now become achievable. This new era of sequencing will enhance diagnostic and therapeutic approaches, providing clinicians with valuable support in their healthcare practice.