期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 8, 期 8, 页码 3361-3376出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.2c00592
关键词
NIR-PTT; ROS-scavenging; oxygen therapy; combination therapy; rheumatoid arthritis treatment
资金
- National Natural Science Foundation of China [21874064, 8167151349, 21871203]
- Natural Science Foundation from Guangdong Science and Technology Department of China [2018A030313456]
- Science and Technology Program of Guangzhou [201904010410]
This study reports a polydopamine-coated CeO2-dopped zeolitic imidazolate framework-8 nanocomposite that can synergistically treat rheumatoid arthritis (RA). Under near-infrared light irradiation, the polydopamine efficiently scavenges reactive oxygen species and increases the temperature in the inflamed area, which helps eliminate inflammatory cells and release encapsulated CeO2 to relieve hypoxia. The constructed composite shows good therapeutic effect on RA through NIR-photothermal/ROS-scavenging/oxygen-enriched combinative therapy.
Rheumatoid arthritis (RA) is an inflammatory type of arthritis that causes joint pain and damage. The inflammatory cell infiltration (e.g., M1 macrophages), the poor O2 supply at the joint, and the excess reactive oxygen species (ROS)-induced oxidative injury are the main causes of RA. We herein report a polydopamine (PDA)-coated CeO2-dopped zeolitic imidazolate framework-8 (ZIF-8) nanocomposite CeO2- ZIF-8@PDA (denoted as CZP) that can synergistically treat RA. Under near-infrared (NIR) light irradiation, PDA efficiently scavenges ROS and results in an increased temperature in the inflamed area because of its good light-to-heat conversion efficiency. The rise of temperature serves to obliterate hyper-proliferative inflammatory cells accumulated in the diseased area while vastly promoting the collapse of the acidic-responsive skeleton of ZIF-8 to release the encapsulated CeO2. The released CeO2 exerts its catalase-like activity to relieve hypoxia by generating oxygen via the decomposition of H2O2 highly expressed in the inflammatory sites. Thus, the constructed CZP composite can treat RA through NIR-photothermal/ROS-scavenging/oxygen-enriched combinative therapy and show good regression of pro-inflammatory cytokines and hypoxia-inducible factor-1 alpha (HIF-1 alpha) in vitro and promising therapeutic effect on RA in rat models. The multimodal nano-platform reported herein is expected to shed light on the design of synergistic therapeutic nanomedicine for effective RA therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据