期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 8, 期 9, 页码 3741-3753出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c01287
关键词
urushiol; antibacterial activity; cross-linking; primer; bonding strength
资金
- Scientific and Technological Development Scheme of Jilin Province [20200201425JC]
Urushiol, as a primer in dentin bonding, improves the biological stability of dentin collagen through cross-linking, inhibits bacterial growth and biofilm formation, and enhances the bonding strength.
Commercial dentin adhesive systems are applied to restorations due to their resistant bonding properties, but they suffer from the lack of bioactivity and are prone to hydrolysis. Therefore, to overcome these limitations, an eco-friendly natural monomer, urushiol, was adopted to be a primer in dentin bonding due to its interaction with collagen and antibacterial activity, preventing further hydrolysis develop-ment. First, urushiol was determined to be capable of improving the biological stability of dentin collagen through cross-linking. Using high-fidelity analytical chemistry techniques, such as Fourier transform infrared spectroscopy, we quantified the effects of urushiol on collagen molecules. It could also effectively decrease weight loss after collagenase ingestion by improving the stability of dentin. Moreover, urushiol inhibited Streptococcus mutans growth as well as its biofilm formation. Finally, we demonstrated that the urushiol primer could improve the bonding strength, particularly after aging. The cross-linking and antibacterial functions of urushiol have provided promising developmental prospects for biomaterials in dentin adhesion.
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