期刊
NANOMATERIALS
卷 12, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/nano12162760
关键词
magnetic hyperthermia; magnetic fluid; maghemite; core-shell; asymptotic temperature; Box-Lucas model
类别
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Apoio a Pesquisa do Distrito Federal (FAPDF)
- Fundacao de Apoio a Pesquisa do Estado de Goias (FAPEG) [201710267000511]
- CNPq [310230/2017-9, 305481/2018-5, 305717/2020-0]
- FAPDF [193-00000188/2019-58]
This study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in MHT assays. By varying the thickness of the gold shell, the study found that gold thickness could control the asymptotic temperature, providing a new strategy for safe MHT use. Thinner gold shell layers showed the highest SAR value and the time required to reach asymptotic temperature could be modeled by changing thermal conductivity and the structure of the nanoparticles.
This study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 +/- 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100-650 kHz) and field amplitudes (9-25 mT). The asymptotic temperatures (T-infinity) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59-77 degrees C (naked maghemite), 44-58 degrees C (g/m=0.0376) and 33-51 degrees C (g/m=0.0752). The MHT data revealed that T-infinity could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T-infinity could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box-Lucas method (which was reported as phenomenological).
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