期刊
GENES
卷 13, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/genes13071278
关键词
CD71+cells; CD71+erythroid cells; human fetal liver; AIRE; tissue specific antigens; TSAs
资金
- Russian Science Foundation [21-15-00087]
The expression of AIRE and TSAs genes was found in CD71+ cells, mainly represented by CD71+ erythroid cells, from human fetal liver parenchyma.
Autoimmune regulator (AIRE) is a multifunctional protein that is capable of inducing tissue-specific antigens' (TSAs) gene expression, a key event in the induction of self-tolerance, that is usually expressed and functions in the thymus. However, its expression has been detected outside the thymus and cells expressing the gene have been named extra-thymic AIRE expressing cells (eTACs). Here, we discuss the finding of AIRE and TSAs gene expression in CD71+ cells from human fetal liver parenchyma, which are mostly represented by CD71+ erythroid cells.
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