Sirtuins promote brain homeostasis, preventing Alzheimer's disease through targeting neuroinflammation

Both basic pathomechanisms underlying Alzheimer's disease and some premises for stipulating a possible preventive role of some sirtuins, especially SIRT1 and SIRT3, protective against Alzheimer's disease-related pathology, are discussed in this article. Sirtuins can inhibit some processes that underlie Alzheimer's disease-related molecular pathology (e.g., neuroinflammation, neuroinflammation-related oxidative stress, A beta aggregate deposition, and neurofibrillary tangle formation), thus preventing many of those pathologic alterations at relatively early stages of their development. Subsequently, the authors discuss in details which mechanisms of sirtuin action may prevent the development of Alzheimer's disease, thus promoting brain homeostasis in the course of aging. In addition, a rationale for boosting sirtuin activity, both with allosteric activators and with NAD(+) precursors, has been presented.

Automated summary

This article discusses the basic pathomechanisms of Alzheimer's disease and the potential preventive role of sirtuins, particularly SIRT1 and SIRT3, in protecting against Alzheimer's disease-related pathology. Sirtuins can inhibit molecular processes associated with the disease, thus preventing its development. The article also explores the mechanisms by which sirtuins may prevent Alzheimer's disease and presents a rationale for boosting sirtuin activity.