期刊
FRONTIERS IN PHYSIOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2022.852795
关键词
basic fiboblast growth factor; tendon injury; tendon repair; tendon healing; mechanism
类别
资金
- Sub-project of Academician Zhong Shizhen Workstation, Joint cultivation project of Southwest Medical University-The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University (Osteopathy of Integrated Traditional Chinese and Western M
- Innovation team project of The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University
- basic research project of the Applied Basic of Southwest Medical University [2021ZKMS050]
- 2020 Luzhou Science and Technology Plan Project Research on Body-Medicine Integration Driving Mechanism [2020-ZRK-60]
- 2020 Southwest Medical University Research Project Research on Body-Medicine Integration Collaborative Innovation Mechanism [2020TYZD002]
- Research on the theory and practice of collaborative innovation in sports rehabilitation - Sichuan Pin-Clad Medical Technology Co. [YK 2020A01]
This review summarizes the effects of bFGF in tendon healing, including the promotion of neovascularization and acceleration of the inflammatory response in the inflammatory phase, stimulation of collagen secretion and acceleration of tendon healing in the cell proliferation phase, and promotion of collagen transition in the remodeling phase. However, excessive injection of bFGF may lead to negative effects.
Tendon injury is a disorder of the musculoskeletal system caused by overuse or trauma, which is characterized by pain and limitations in joint function. Since tendon healing is slowly and various treatments are generally ineffective, it remains a clinically challenging problem. Recent evidences suggest that basic fibroblast growth factor (bFGF) not only plays an important role in tendon healing, but also shows a positive effect in laboratory experimentations. The purpose of this review is to summarize the effects of bFGF in the tendon healing. Firstly, during the inflammatory phase, bFGF stimulates the proliferation and differentiation of vascular endothelial cells to foster neovascularization. Furthermore, bFGF enhances the production of pro-inflammatory factors during the early phase of tendon healing, thereby accelerating the inflammatory response. Secondly, the cell proliferation phase is accompanied by the synthesis of a large number of extracellular matrix components. bFGF speeds up tendon healing by stimulating fibroblasts to secrete type III collagen. Lastly, the remodeling phase is characterized by the transition from type III collagen to type I collagen, which can be promoted by bFGF. However, excessive injection of bFGF can cause tendon adhesions as well as scar tissue formation. In future studies, we need to explore further applications of bFGF in the tendon healing process.
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