4.6 Review

Sirtuins and cognition: implications for learning and memory in neurological disorders

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Plant Sciences

BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice

Lin Li et al.

Summary: The study found that BZBS can improve cognitive and motor functions in aging mice, maintain redox balance, alleviate immunosenescence, and preserve telomerase activity and length. Additionally, BZBS can inhibit rapid aging in mice by reducing the expressions of P53, caspase-3, and Bax, while increasing the expressions of Sirt6, p-HO-1, p-NRF2, PGC-1 alpha, and Bcl-2.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Neurosciences

Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol

Lin-Hui Ma et al.

Summary: Repeated neonatal propofol exposure can lead to cognitive dysfunction later in life, which is characterized by reduced SIRT1 expression, suppressed synaptic plasticity, and decreased neuronal excitability in the hippocampus. Overexpression of SIRT1 attenuates propofol-induced cognitive dysfunction and synaptic plasticity damage.

MOLECULAR NEUROBIOLOGY (2022)

Review Behavioral Sciences

Multifaced role of protein deacetylase sirtuins in neurodegenerative disease

Rohan Gupta et al.

Summary: Sirtuins, a class III histone/protein deacetylase, play a central role in regulating metabolic function and cellular stress response. They are involved in the pathogenesis and progression of neurodegenerative diseases and are considered as potential therapeutic targets. Manipulating sirtuins activity, calorie restriction, and miR-based therapies have shown promise in treating neurodegenerative diseases.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2022)

Review Clinical Neurology

Vascular Cognitive Impairment (VCI)

Tatjana Rundek et al.

Summary: Vascular cognitive impairment (VCI) is mainly caused by vascular risk factors and cerebrovascular disease, accounting for 20-40% of all dementia diagnoses. Cerebrovascular pathology is the most important contributor to dementia, with interactions with neurodegenerative pathology. Controlling vascular risk factors plays a key role in the prevention and treatment of VCI.

NEUROTHERAPEUTICS (2022)

Article Critical Care Medicine

The Montreal Cognitive Assessment is a valid cognitive screening tool for cardiac arrest survivors

Pauline van Gils et al.

Summary: This study examines the diagnostic value of the Montreal Cognitive Assessment (MoCA) in patients after out-of-hospital cardiac arrest (OHCA). The results show that the MoCA has good sensitivity and adequate specificity in identifying cognitive impairment, with a high negative predictive value.

RESUSCITATION (2022)

Article Biology

SIRT2 and FOXO3a expressions in the cerebral cortex and hippocampus of young and aged male rats: antioxidant and anti-apoptotic effects of melatonin

Arzu Keskin-Aktan et al.

Summary: Melatonin can reduce the expression of SIRT2 and FOXO3a, decrease oxidative stress and pro-apoptotic proteins, as well as increase antioxidant capacity and anti-apoptotic proteins in the brains of aged rats, with a more pronounced effect in the hippocampus.

BIOLOGIA FUTURA (2022)

Article Clinical Neurology

Reduced serum SIRT1 levels in patients with Parkinson's disease: a cross-sectional study in China

Yuting Zhu et al.

Summary: The study detected reduced serum SIRT1 levels in PD patients compared to healthy controls, which were associated with disease severity and cognitive function. ROC analysis indicated that serum SIRT1 may serve as a potential biomarker for PD with diagnostic value.

NEUROLOGICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

SIRT5 Represses Neurotrophic Pathways and Aβ Production in Alzheimer's Disease by Targeting Autophagy

Shanshan Wu et al.

Summary: The study revealed that SIRT5 plays a crucial role in the treatment of Alzheimer's disease (AD), as its overexpression can ameliorate AD progression by activating autophagy, reducing oxidative stress, and protecting neurons by inhibiting activated microglia and astrocytes. This therapeutic approach shows promise for AD treatment.

ACS CHEMICAL NEUROSCIENCE (2021)

Article Pharmacology & Pharmacy

Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

Xiang-Sheng Zhang et al.

Summary: The study showed that astaxanthin significantly reduced oxidative stress and neuronal apoptosis after traumatic brain injury. Astaxanthin improved neurological functions through the SIRT1/Nrf2/Prx2/ASK1/p38 signaling pathway, suggesting it as a potential candidate for alleviating traumatic brain injury.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3

Hai-Jian Sun et al.

Summary: Sodium tetrasulfide (Na2S4) treatment can ameliorate diabetic kidney disease by inhibiting inflammation cytokines and reducing oxidative stress, renal fibrosis, and cell apoptosis. Na2S4 acts through sulfhydrating SIRT1 to deactivate p65 NF-kappa B and STAT3 phosphorylation/acetylation, ultimately reducing oxidative stress, inflammation response, and EMT progression in renal tubular epithelial cells.

REDOX BIOLOGY (2021)

Article Sport Sciences

Changes in mitochondrial biogenesis and fatty liver indicators in rat following continuous and high intensity interval training

Fatemeh Heiat et al.

Summary: The study demonstrated that continuous swimming training can increase the levels of PGC-1 alpha and SIRT3 in hepatocytes, while significantly reducing levels of LDL, TG, and FBS. On the other hand, high-intensity interval swimming training can significantly increase SIRT3 levels and decrease FBS levels, showing some effectiveness in improving fatty liver markers.

JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS (2021)

Review Medicine, Research & Experimental

A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism

Shahab Shahgaldi et al.

Summary: Sirtuins, a class of protein deacetylases, are highly regulated and play crucial roles in regulating fundamental biological processes such as inflammation, metabolism, and cell senescence. Their ability to target multiple intracellular proteins makes them key players in cellular redox homeostasis and bioenergetics.

LIFE SCIENCES (2021)

Article Immunology

Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation

Qiang Liu et al.

Summary: This study found that SIRT3 can improve postoperative cognitive dysfunction in aged mice by suppressing hippocampal neuroinflammation, and may be a promising therapeutic and diagnostic target for POCD.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Clinical Neurology

Sirtuin 5-Mediated Lysine Desuccinylation Protects Mitochondrial Metabolism Following Subarachnoid Hemorrhage in Mice

Zhi-Peng Xiao et al.

Summary: The study revealed that protein lysine succinylation is altered after subarachnoid hemorrhage, and activation of Sirt5 helps restore mitochondrial metabolism and alleviate early brain injury.

STROKE (2021)

Article Nutrition & Dietetics

Impact of Dietary Modifications on Plasma Sirtuins 1, 3 and 5 in Older Overweight Individuals Undergoing 12-Weeks of Circuit Training

Paulina Wasserfurth et al.

Summary: The study found that exercise intervention significantly increased the activity of SIRT1 and SIRT3, with additional dietary modifications potentially enhancing this increase.

NUTRIENTS (2021)

Article Biochemistry & Molecular Biology

Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice

Xiao Le Tang et al.

Summary: Sevoflurane exposure leads to cognitive impairment in developing mice, which is ameliorated by resveratrol treatment through modulating the balance of microglia functions in the SIRT1 and NF-kappa B pathways.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

H2S Attenuates Sleep Deprivation-Induced Cognitive Impairment by Reducing Excessive Autophagy via Hippocampal Sirt-1 in WISTAR RATS

Shan Gao et al.

Summary: The study showed that H2S can reverse cognitive impairment caused by SD and inhibit excessive hippocampal autophagy induced by SD in rats, possibly through upregulation of Sirt-1.

NEUROCHEMICAL RESEARCH (2021)

Article Critical Care Medicine

Cognitive dysfunction after out-of-hospital cardiac arrest: Rate of impairment and clinical predictors

Aziza Byron-Alhassan et al.

Summary: The study found that 43% of OHCA survivors experienced cognitive impairment, compared to only around 7% of MI patients. Cognitive impairment primarily affected attention, memory, language, and executive function.

RESUSCITATION (2021)

Article Medicine, Research & Experimental

Effects of Shenfu Qiangxin Drink on H2O2-induced oxidative stress, inflammation and apoptosis in neonatal rat cardiomyocytes and possible underlying mechanisms

Sujie Zhang et al.

Summary: This study found that Shenfu Qiangxin Drink may alleviate oxidative stress-induced myocardial injury by potentially regulating SIRT4/FOXO3a signaling pathway, suggesting its potential clinical value in the treatment of acute myocardial infarction.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Medicine, General & Internal

Alzheimer disease

David S. Knopman et al.

Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive impairments. The pathophysiology involves a complex interplay of loss of synaptic homeostasis and dysfunction in endosomal/lysosomal clearance pathways. Therapeutic options are still being sought to substantially alter the clinical course of individuals with Alzheimer's disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Clinical Neurology

Stroke and dementia, leading causes of neurological disability and death, potential for prevention

Abolfazl Avan et al.

Summary: In 2019, stroke accounted for 69.8% and dementia for 17.3% of neurological deaths globally. The number of cases for stroke and dementia is increasing, but their age-standardized rates are falling, offering the possibility of joint delay, mitigation, or prevention. Globally, hypertension and unhealthy diet pose the greatest risk for stroke DALYs, while smoking and obesity are significant factors for dementia DALYs.

ALZHEIMERS & DEMENTIA (2021)

Article Neurosciences

SIRT1 Protects Dopaminergic Neurons in Parkinson's Disease Models via PGC-1α-Mediated Mitochondrial Biogenesis

Yu Chen et al.

Summary: The study revealed that SIRT1 has neuroprotective effects on dopaminergic neurons by promoting cell survival, maintaining mitochondrial function, and reducing cell apoptosis. These effects are dependent on SIRT1-mediated mitochondrial biogenesis via PGC-1α, suggesting great therapeutic potential of SIRT1 for disorders associated with dopaminergic neuron loss such as PD.

NEUROTOXICITY RESEARCH (2021)

Article Physiology

Involvement of Sirtuins and Klotho in Cardioprotective Effects of Exercise Training Against Waterpipe Tobacco Smoking-Induced Heart Dysfunction

Samaneh Sadat Alavi et al.

Summary: Waterpipe smoking (WPS) can cause left ventricular dysfunction in rats, while moderate endurance exercise may partially prevent WPS-induced heart dysfunction, possibly through its anti-apoptotic features and activation of the sirtuins and Klotho pathways.

FRONTIERS IN PHYSIOLOGY (2021)

Article Clinical Neurology

Effect of ApoE isoforms on mitochondria in Alzheimer disease

Junxiang Yin et al.

NEUROLOGY (2020)

Article Neurosciences

Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices

Joana Sa de Almeida et al.

FRONTIERS IN NEUROSCIENCE (2020)

Article Geriatrics & Gerontology

The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men

Babak Hooshmand-Moghadam et al.

EXPERIMENTAL GERONTOLOGY (2020)

Review Medicine, Research & Experimental

Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

Jin Zhang et al.

THERANOSTICS (2020)

Article Biochemistry & Molecular Biology

Decreased Neuron Number and Synaptic Plasticity in SIRT3-Knockout Mice with Poor Remote Memory

Hyopil Kim et al.

NEUROCHEMICAL RESEARCH (2019)

Article Neurosciences

Exercise activates lysosomal function in the brain through AMPK-SIRT1-TFEB pathway

Jun Huang et al.

CNS NEUROSCIENCE & THERAPEUTICS (2019)

Article Biochemical Research Methods

Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions

Cora N. Betsinger et al.

JOURNAL OF PROTEOME RESEARCH (2019)

Article Biochemistry & Molecular Biology

Activation of liver x receptors prevents the spinal LTP induced by skin/muscle retraction in the thigh via SIRT1/NF-Kb pathway

Xiongxiong Zhong et al.

NEUROCHEMISTRY INTERNATIONAL (2019)

Article Biochemistry & Molecular Biology

One year of exercise training promotes distinct adaptations in right and left ventricle of female Sprague-Dawley rats

Rita Nogueira-Ferreira et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2019)

Review Geriatrics & Gerontology

SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases

Hao Meng et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Review Neurosciences

Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options

Jeffrey L. Cummings et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Biochemistry & Molecular Biology

Sirt3-dependent deacetylation of COX-1 counteracts oxidative stress-induced cell apoptosis

Long-Fang Tu et al.

FASEB JOURNAL (2019)

Review Biochemistry & Molecular Biology

The NAD(+)-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning

Nathalie Khoury et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Biochemistry & Molecular Biology

SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH2-terminal kinase

Mohsen Sarikhani et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Cell Biology

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

Meng-yu Wu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

Xiu-Fei Chen et al.

EMBO REPORTS (2018)

Article Biochemistry & Molecular Biology

SIRT7 functions in redox homeostasis and cytoskeletal organization during oocyte maturation

Min Gao et al.

FASEB JOURNAL (2018)

Article Neurosciences

Amyloid- Increases Tau by Mediating Sirtuin 3 in Alzheimer's Disease

Junxiang Yin et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Multidisciplinary Sciences

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Yujun Hou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

SIRT6 facilitates directional telomere movement upon oxidative damage

Ying Gao et al.

SCIENTIFIC REPORTS (2018)

Article Biotechnology & Applied Microbiology

Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction

Zhaoling Shi et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Article Medicine, Research & Experimental

Effect of Sirtuin-1 on Synaptic Plasticity in Nucleus Accumbens in a Rat Model of Heroin Addiction

Baijuan Xia et al.

MEDICAL SCIENCE MONITOR (2018)

Review Clinical Neurology

Treatments to Promote Neural Repair after Stroke

Steven C. Cramer

JOURNAL OF STROKE (2018)

Review Biochemistry & Molecular Biology

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C. Cheignon et al.

REDOX BIOLOGY (2018)

Article Multidisciplinary Sciences

SIRT6 deficiency results in developmental retardation cynomolgus monkeys

Weiqi Zhang et al.

NATURE (2018)

Review Clinical Neurology

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

Miia Kivipelto et al.

NATURE REVIEWS NEUROLOGY (2018)

Review Cardiac & Cardiovascular Systems

Prediction of cognitive dysfunction after resuscitation - a systematic review

Wioletta A. Medrzycka-Dabrowska et al.

POSTEPY W KARDIOLOGII INTERWENCYJNEJ (2018)

Article Biochemistry & Molecular Biology

Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC- la-SOD2-mediated regulation of mitochondrial function

Yong Ding et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

Review Clinical Neurology

Alzheimer's Disease: Past, Present, and Future

Mark W. Bondi et al.

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2017)

Review Clinical Neurology

Potential oxidative stress biomarkers of mild cognitive impairment due to Alzheimer disease

Ana Garcia-Blanco et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

Review Clinical Neurology

Alzheimer's disease prevention: from risk factors to early intervention

Marta Crous-Bou et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

Article Clinical Neurology

Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration

Preeti Singh et al.

PARKINSONS DISEASE (2017)

Article Clinical Neurology

Serum tau and neurological outcome in cardiac arrest

Niklas Mattsson et al.

ANNALS OF NEUROLOGY (2017)

Article Biochemistry & Molecular Biology

Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy

Guoxiang Liu et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

Article Neurosciences

The use of MMSE and MoCA in patients with acute ischemic stroke in clinical

Yi-Jun Shen et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2016)

Article Biochemistry & Molecular Biology

PGC-1α/ERRα-Sirt3 Pathway Regulates DAergic Neuronal Death by Directly Deacetylating SOD2 and ATP Synthase β

Xuefei Zhang et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Article Neurosciences

Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior

Naoko Abe-Higuchi et al.

BIOLOGICAL PSYCHIATRY (2016)

Review Biochemistry & Molecular Biology

Using mitochondrial sirtuins as drug targets: disease implications and available compounds

Melanie Gertz et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Clinical Neurology

Cognitive and Functional Consequence of Cardiac Arrest

Claudia A. Perez et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2016)

Article Biochemistry & Molecular Biology

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

Lisha Zhou et al.

EMBO REPORTS (2016)

Review Biochemistry & Molecular Biology

The role of mitochondrial sirtuins in health and disease

Brenna Osborne et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Medicine, Research & Experimental

SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro

Ying-Wei Ding et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Article Surgery

Cognitive impairment after sudden cardiac arrest

Magdalena Jaszke-Psonka et al.

KARDIOCHIRURGIA I TORAKOCHIRURGIA POLSKA (2016)

Article Biochemistry & Molecular Biology

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

Luisa Tasselli et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Review Neurosciences

The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

Heidi Martini-Stoica et al.

TRENDS IN NEUROSCIENCES (2016)

Article Biochemistry & Molecular Biology

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

Luisa Tasselli et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Multidisciplinary Sciences

Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5

Kahlilia C. Morris-Blanco et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp

Bor-Jang Hwang et al.

BMC MOLECULAR BIOLOGY (2015)

Article Clinical Neurology

Post-stroke cognitive impairment is common even after successful clinical recovery

H. Jokinen et al.

EUROPEAN JOURNAL OF NEUROLOGY (2015)

Article Clinical Neurology

Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

M. Erburu et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3

Pankaj K. Bagul et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2015)

Article Critical Care Medicine

Cognitive function and health-related quality of life four years after cardiac arrest

Eirik Alnes Buanes et al.

RESUSCITATION (2015)

Article Critical Care Medicine

Neurocognitive outcomes following successful resuscitation from cardiac arrest

Alexa R. Sabedra et al.

RESUSCITATION (2015)

Review Clinical Neurology

The Role of Na+/Ca2+ Exchanger Subtypes in Neuronal Ischemic Injury

Botros Shenoda

TRANSLATIONAL STROKE RESEARCH (2015)

Review Biotechnology & Applied Microbiology

Working Memory and Executive Function Decline across Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease

Anna-Mariya Kirova et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Review Neurosciences

Association between Stroke and Alzheimer's Disease: Systematic Review and Meta-Analysis

Jing Zhou et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Biochemistry & Molecular Biology

Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response

Alessio Cardinale et al.

NEUROCHEMICAL RESEARCH (2015)

Article Cell Biology

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

Dongryeol Ryu et al.

CELL METABOLISM (2014)

Article Biochemistry & Molecular Biology

Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis

Shu-Hui Dai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Biochemistry & Molecular Biology

Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid

Jennifer Shih et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Geriatrics & Gerontology

Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity

Pengcheng Han et al.

NEUROBIOLOGY OF AGING (2014)

Article Neurosciences

Distinct Patterns of Sirtuin Expression During Progression of Alzheimer's Disease

Mirjam I. Lutz et al.

NEUROMOLECULAR MEDICINE (2014)

Article Critical Care Medicine

Cerebrospinal fluid biomarkers in cardiac arrest survivors

Christoffer Rosen et al.

RESUSCITATION (2014)

Review Clinical Neurology

Use of Montreal Cognitive Assessment in Patients With Stroke

Guido Chiti et al.

STROKE (2014)

Review Neurosciences

Oxidative stress in Alzheimer's disease

Zhichun Chen et al.

NEUROSCIENCE BULLETIN (2014)

Article Biochemistry & Molecular Biology

SIRT5 desuccinylates and activates SOD1 to eliminate ROS

Zhi-Feng Lin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal

Shashi Kiran et al.

FEBS JOURNAL (2013)

Review Biochemistry & Molecular Biology

Redox regulation of SIRT1 in inflammation and cellular senescence

Jae-woong Hwang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Editorial Material Neurosciences

Epigenetics of Methamphetamine-Induced Changes in Glutamate Function

Jean Lud Cadet et al.

NEUROPSYCHOPHARMACOLOGY (2013)

Article Multidisciplinary Sciences

Sirtuin1: A Promising Serum Protein Marker for Early Detection of Alzheimer's Disease

Rahul Kumar et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

Yusuke S. Hori et al.

PLOS ONE (2013)

Article Clinical Neurology

Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage

Macarena Hernandez-Jimenez et al.

STROKE (2013)

Review Biochemistry & Molecular Biology

Reactivation of latent HIV by histone deacetylase inhibitors

Kotaro Shirakawa et al.

TRENDS IN MICROBIOLOGY (2013)

Review Biochemistry & Molecular Biology

NADPH oxidases as therapeutic targets in ischemic stroke

Timo Kahles et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Neurosciences

Cerebral Hypoperfusion and Cognitive Impairment: The Pathogenic Role of Vascular Oxidative Stress

Hui Liu et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2012)

Article Biochemistry & Molecular Biology

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

Wei Yu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

Matthew F. Barber et al.

NATURE (2012)

Article Multidisciplinary Sciences

The sirtuin SIRT6 regulates lifespan in male mice

Yariv Kanfi et al.

NATURE (2012)

Article Geriatrics & Gerontology

Selective white matter abnormalities in a novel rat model of vascular dementia

Akihiro Kitamura et al.

NEUROBIOLOGY OF AGING (2012)

Article Clinical Neurology

Neuropsychiatric symptoms in Alzheimer’s disease

Constantine G. Lyketsos et al.

Alzheimers & Dementia (2011)

Article Biochemistry & Molecular Biology

SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

Sergiy Libert et al.

Article Biochemistry & Molecular Biology

Does Serum Tau Protein Predict the Outcome of Patients with Ischemic Stroke?

Joanna Bielewicz et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2011)

Article Multidisciplinary Sciences

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

Zhiyong Mao et al.

SCIENCE (2011)

Review Biochemistry & Molecular Biology

Mitochondria, oxidative metabolism and cell death in stroke

Neil R. Sims et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)

Article Neurosciences

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

Shaday Michan et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

Masato Iwabu et al.

NATURE (2010)

Article Multidisciplinary Sciences

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

Jun Gao et al.

NATURE (2010)

Article Cell Biology

PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

Bin Zheng et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Review Medicine, General & Internal

Serotonin, genetic variability, behaviour, and psychiatric disorders - a review

Niklas Nordquist et al.

UPSALA JOURNAL OF MEDICAL SCIENCES (2010)

Article Biochemistry & Molecular Biology

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

Takashi Nakagawa et al.

Article Clinical Neurology

Frequency and predictors for the risk of stroke recurrence up to 10 years after stroke: the South London Stroke Register

K. M. Mohan et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2009)

Article Clinical Neurology

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

Carl Julien et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)

Article Geriatrics & Gerontology

Executive Decline and Dysfunction Precedes Declines in Memory: The Women's Health and Aging Study II

Michelle C. Carlson et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)

Article Multidisciplinary Sciences

CBP/p300-mediated acetylation of histone H3 on lysine 56

Chandrima Das et al.

NATURE (2009)

Review Critical Care Medicine

Cognitive impairments in survivors of out-of-hospital cardiac arrest: A systematic review

Veronique R. M. P. Moulaert et al.

RESUSCITATION (2009)

Article Biochemistry & Molecular Biology

Where in the cell is SIRT3? – functional localization of an NAD+-dependent protein deacetylase

William C. Hallows et al.

BIOCHEMICAL JOURNAL (2008)

Review Chemistry, Medicinal

Oxidative stress and neurotoxicity

Lawrence M. Sayre et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2008)

Article Cardiac & Cardiovascular Systems

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

Olesya Vakhrusheva et al.

CIRCULATION RESEARCH (2008)

Article Multidisciplinary Sciences

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Eriko Michishita et al.

NATURE (2008)

Review Pharmacology & Pharmacy

Oxidative stress hypothesis in Alzheimer's disease: a reappraisal

Domenico Pratico

TRENDS IN PHARMACOLOGICAL SCIENCES (2008)

Article Biochemistry & Molecular Biology

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacrtylase SIRT1

Masaya Tanno et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

Bjoern Schwer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Cell Biology

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

Alejandro Vaquero et al.

GENES & DEVELOPMENT (2006)

Article Clinical Neurology

Circulating beta amyloid protein is elevated in patients with acute ischemic stroke

PH Lee et al.

JOURNAL OF NEURAL TRANSMISSION (2005)

Article Biochemistry & Molecular Biology

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

G Liszt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α

S Nemoto et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes

T Shi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Clinical Neurology

Predictors of reversible mild cognitive impairment after stroke: a 2-year follow-up study

SMC Rasquin et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2005)

Article Clinical Neurology

Ten year recurrence after first ever stroke in a Japanese community: the Hisayama study

J Hata et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2005)

Article Biochemistry & Molecular Biology

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1

A van der Horst et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

H Daitoku et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Critical Care Medicine

In-hospital cardiac arrest leads to chronic memory impairment

SM O'Reilly et al.

RESUSCITATION (2003)

Article Multidisciplinary Sciences

Neurodegenerative disease - Amyloid pores from pathogenic mutations

HA Lashuel et al.

NATURE (2002)