A novel necroptosis-related LncRNA signature for prediction of prognosis and therapeutic responses of head and neck squamous cell carcinoma

Article Cell Biology

Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma

Zixuan Wu et al.

Aging-US (2022)

Article Multidisciplinary Sciences

Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer

Zaoqu Liu et al.

Summary: The study developed a machine learning-based method to predict prognosis, recurrence, and treatment benefits in colorectal cancer patients, and constructed an immune-related long non-coding RNA signature.

NATURE COMMUNICATIONS (2022)

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Review Biochemistry & Molecular Biology

Targeting Necroptosis as a Promising Therapy for Alzheimer's Disease

Wenli Zhao et al.

Summary: This article summarizes the potential role of necroptosis in Alzheimer's disease progression and explores the therapeutic capacity of targeting necroptosis for AD patients.

ACS CHEMICAL NEUROSCIENCE (2022)

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Article Oncology

Use of Immune Checkpoint Inhibitor Pembrolizumab in the Treatment of High-Risk, Early-Stage Triple-Negative Breast Cancer: ASCO Guideline Rapid Recommendation Update

Larissa A. Korde et al.

Summary: ASCO Rapid Recommendations Updates aim to improve cancer care recommendations by providing timely updates to better inform healthcare practitioners and the public about the best available care options.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Biotechnology & Applied Microbiology

lncRNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5

Yingying Jiang et al.

Summary: VN1R5 and its downstream target lnc-POP1-1 are key proteins related to cisplatin resistance, affecting the repair of DNA damage in HNSCC cells through the regulation of MCM5.

MOLECULAR THERAPY (2022)

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Article Medicine, Research & Experimental

Bulk and single-cell transcriptome profiling reveal necroptosis-based molecular classification, tumor microenvironment infiltration characterization, and prognosis prediction in colorectal cancer

Wenqin Luo et al.

Summary: The roles of necroptosis-related genes in colorectal cancer have been comprehensively explored in this study. The findings provide insights into the biological functions of necroptosis, as well as prognosis prediction, drug selection, and therapeutics development in colorectal cancer.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Article Cell Biology

M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway

Huaili Jiang et al.

Summary: This study revealed that M1-derived exosomes containing HOTTIP activate the TLR5/NF-kappa B signaling pathway by competitively sponging miR-19a-3p and miR-19b-3p, thereby suppressing the progression of head and neck squamous cell carcinoma (HNSCC). Additionally, M1-derived exosomes and HOTTIP induce the polarization of circulating monocytes towards an M1 phenotype, providing new insights into HNSCC immunotherapy.

CELL DEATH & DISEASE (2022)

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Article Oncology

Identification of pyroptosis-related gene prognostic signature in head and neck squamous cell carcinoma

Zhanzhan Li et al.

Summary: We constructed and validated a risk model for HNSCC prognosis using seven pyroptosis-related signature genes, which could predict the overall survival of HNSCC patients and facilitate treatment.

CANCER MEDICINE (2022)

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Article Oncology

Development of a prediction model for radiotherapy response among patients with head and neck squamous cell carcinoma based on the tumor immune microenvironment and hypoxia signature

Guang-Li Zhu et al.

Summary: This study developed a model to predict radiotherapy response in patients with head and neck squamous cell carcinoma based on the tumor immune microenvironment and hypoxia signature, and validated its efficacy.

CANCER MEDICINE (2022)

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Article Oncology

A necroptosis-related gene signature for predicting prognosis, immune landscape, and drug sensitivity in hepatocellular carcinoma

Junliang Chen et al.

Summary: The necroptosis-related gene signature provides a new method for the risk stratification and treatment optimization of HCC. The nomogram can further improve predictive accuracy.

CANCER MEDICINE (2022)

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Article Immunology

A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer

Xin Zhang et al.

Summary: In this study, a prognostic signature consisting of 7 necroptosis-associated lncRNAs was established to independently predict the clinical outcome of breast cancer patients. The difference in tumor immune microenvironment between low- and high-risk groups may be the reason for resistance to immunotherapy in some patients.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

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Article Genetics & Heredity

A Novel Inflammatory Response-Related Gene Signature Improves High-Risk Survival Prediction in Patients With Head and Neck Squamous Cell Carcinoma

Yanxun Han et al.

Summary: A prognostic model consisting of 14 inflammatory-related genes was constructed for head and neck squamous cell carcinoma (HNSCC), with the high-risk group showing significantly shorter overall survival. Immune infiltration analysis revealed higher abundance of various immune cells in the low-risk group, with risk scores correlating with chemotherapeutic sensitivity and immune checkpoint genes expression.

FRONTIERS IN GENETICS (2022)

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Review Cell Biology

Necroptosis and Prostate Cancer: Molecular Mechanisms and Therapeutic Potential

Giovanni Luca Beretta et al.

Summary: Necroptosis is a cell death mechanism characterized by inflammatory reactions and is involved in viral defense, inflammatory diseases, and drug response of tumors such as prostate cancer.

CELLS (2022)

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Article Cell Biology

Integrated Analysis of Multi-Omics Alteration, Immune Profile, and Pharmacological Landscape of Pyroptosis-Derived lncRNA Pairs in Gastric Cancer

Chunguang Guo et al.

Summary: This study comprehensively analyzed multi-omics data from three independent cohorts of gastric cancer patients and found that pyroptosis-derived long non-coding RNAs (PDLs) play important roles in the biological process and prognosis of gastric cancer. By constructing a pyroptosis-derived lncRNA pair prognostics signature (PLPPS) model, it can help improve the prognostic management and personalized treatment of gastric cancer patients.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Cell Biology

Necroptosis and Viral Myocarditis: Tumor Necrosis Factor α as a Novel Biomarker for the Diagnosis of Viral Myocarditis

Jin Zhou et al.

Summary: Programmed cell death, including necroptosis, plays an important role in cardiovascular diseases such as viral myocarditis. This review summarizes the evidence on the pathogenesis, molecule mechanism, diagnosis, and potential treatment strategies of viral myocarditis, with a special focus on the novel mechanism of necroptosis for cardiomyocytes death. Studies have shown that tumor necrosis factor-alpha (TNF-alpha) is involved in the activation of necroptosis and may have diagnostic implications for viral myocarditis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Medicine, General & Internal

Inflammation-Related Gene Signature for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma

Yilong Lu et al.

Summary: This study established a novel prognostic signature consisting of 7 hub genes for the prediction of prognosis in patients with HNSCC. A nomogram model was generated to improve accuracy of prognosis evaluation. The immune cell infiltration analysis revealed that 5 hub genes were associated with tumor purity and immune cell infiltration.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

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Article Medicine, General & Internal

Multi-Omics Approaches Identify Necroptosis-Related Prognostic Signature and Associated Regulatory Axis in Cervical Cancer

JuanMei Zhan et al.

Summary: In this study, a prognostic signature related to necroptosis consisting of 13 genes was developed for cervical cancer. Additionally, a regulatory axis involving lncRNA NUTM2B-AS1/miR-361-5p/TNF was identified, which may play a crucial role in the progression of cervical cancer.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

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Article Biochemical Research Methods

Prognosis and personalized treatment prediction in TP53-mutant hepatocellular carcinoma: an in silico strategy towards precision oncology

Chen Yang et al.

Summary: This study retrospectively analyzed 1135 HCC patients and developed a random forest-based prediction model to estimate TP53 mutational status, as well as a robust poor prognosis-associated signature which showed superior ability to predict survival in TP53-mutant patients. In silico screening revealed three targets and two agents that might have potential therapeutic implications in high-PPS patients, presenting a comprehensive view of potential treatment strategy.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Cell Biology

TTN/OBSCN 'Double-Hit' predicts favourable prognosis, 'immune-hot' subtype and potentially better immunotherapeutic efficacy in colorectal cancer

Zaoqu Liu et al.

Summary: A recent study revealed that CRC patients with TTN/OBSCN 'Double-Hit' phenotype had significantly better prognosis, an 'immune-hot' subtype, and potentially better immunotherapeutic efficacy.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Microbiology

DNA Methylation and HPV-Associated Head and Neck Cancer

Takuya Nakagawa et al.

Summary: Head and neck squamous cell carcinoma, especially oropharyngeal squamous cell carcinoma, is significantly associated with human papillomavirus (HPV) infection. While HPV-associated OPSCC generally has a better prognosis, a subset of patients still show poor outcomes or response to therapy, with the molecular mechanisms behind this phenomenon in the intermediate-risk group remaining unclear. Differences in mutation patterns partly explain the biological differences between HPV-associated HNSCC and HPV-negative HNSCC.

MICROORGANISMS (2021)

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Article Cell Biology

Establishment and experimental validation of an immune miRNA signature for assessing prognosis and immune landscape of patients with colorectal cancer

Zaoqu Liu et al.

Summary: A miRNA prognostic signature (IAMIPS) was developed and validated for evaluating overall survival and inflammatory landscape of CRC patients, proving to be more accurate than traditional clinical stage. Patients in the high-risk group showed worse outcomes and IAMIPS remained a powerful independent predictor for OS even after stratification for clinical factors.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Immunology

IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures

Dongqiang Zeng et al.

Summary: Recent advances in next-generation sequencing technologies have led to a rapid accumulation of publicly available multi-omics datasets. The development of IOBR as a computational tool aims to comprehensively interpret multi-omics data and facilitate immuno-oncology exploration for precision immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Effect of a multidisciplinary Severe Immunotherapy Complications Service on outcomes for patients receiving immune checkpoint inhibitor therapy for cancer

Leyre Zubiri et al.

Summary: The study found that establishing a highly specialized care team focused on IRAEs is associated with improved patient outcomes and reduced healthcare utilization. Additionally, the SIC Service successfully integrated blood and tissue collection safety into routine care.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Medicine, Research & Experimental

Inhibition of kras-derived exosomes downregulates immunosuppressive BACH2/GATA-3 expression via RIP-3 dependent necroptosis and miR-146/miR-210 modulation

Savvas Petanidis et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biotechnology & Applied Microbiology

Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Linlin Ma et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Review Medicine, General & Internal

Head and Neck Cancer

Laura Q. M. Chow

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Oncology

Machine-Learning-Based Prediction of Treatment Outcomes Using MR Imaging-Derived Quantitative Tumor Information in Patients with Sinonasal Squamous Cell Carcinomas: A Preliminary Study

Noriyuki Fujima et al.

CANCERS (2019)

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Article Multidisciplinary Sciences

DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

Hyunchul Jung et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NE-κB pathway activation through RPS3

Zixian Huang et al.

CELL DEATH & DISEASE (2019)

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Article Multidisciplinary Sciences

Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer

Carolina Moretto Carnielli et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Clonal dynamics in osteosarcoma defined by RGB marking

Stefano Gambera et al.

NATURE COMMUNICATIONS (2018)

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Review Oncology

Implementing tumor mutational burden (TMB) analysis in routine diagnostics-a primer for molecular pathologists and clinicians

Michael Allgaeuer et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2018)

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Article Biochemistry & Molecular Biology

A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth

Jin-Zhou Huang et al.

MOLECULAR CELL (2017)

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Article Multidisciplinary Sciences

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Laura A. Laviolette et al.

NATURE COMMUNICATIONS (2017)

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Article Cell Biology

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Pornpimol Charoentong et al.

CELL REPORTS (2017)

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Article Genetics & Heredity

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

Zachary R. Chalmers et al.

GENOME MEDICINE (2017)

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Article Oncology

Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer

Fuquan Zhang et al.

CANCER BIOLOGY & THERAPY (2017)

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Article Biochemistry & Molecular Biology

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer

D. S. Matassa et al.

CELL DEATH AND DIFFERENTIATION (2016)

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The relationship between nuclear factor (NF)-κB family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment

Ji-Yeon Kim et al.

SCIENTIFIC REPORTS (2016)

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Global Cancer Statistics, 2012

Lindsey A. Torre et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2015)

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Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Agnieszka K. Witkiewicz et al.

NATURE COMMUNICATIONS (2015)

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Article Oncology

Prediction of recurrence-free survival using a protein expression-based risk classifier for head and neck cancer

S. S. Chauhan et al.

ONCOGENESIS (2015)

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Article Statistics & Probability

A SIGNIFICANCE TEST FOR THE LASSO

Richard Lockhart et al.

ANNALS OF STATISTICS (2014)

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Article Biology

Simultaneous discovery of rare and common segment variants

X. Jessie Jeng et al.

BIOMETRIKA (2013)

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Gene set enrichment analysis: performance evaluation and usage guidelines

Jui-Hung Hung et al.

BRIEFINGS IN BIOINFORMATICS (2012)

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Article Oncology

Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma

Ahmed O. Kaseb et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

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Letter Genetics & Heredity

GenePattern 2.0

M Reich et al.

NATURE GENETICS (2006)

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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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A novel necroptosis-related LncRNA signature for prediction of prognosis and therapeutic responses of head and neck squamous cell carcinoma

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