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Kanglaite (Coix Seed Extract) as Adjunctive Therapy in Cancer: Evidence Mapping Overview Based on Systematic Reviews With Meta-Analyses

FRONTIERS IN PHARMACOLOGY (2022)

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Editorial Material Integrative & Complementary Medicine

Health technology assessment and economic evaluation: Is it applicable for the traditional medicine?

Yingyao Chen

Summary: The gap between limited health resources and expanding health service demands is driving the need for cost-effective strategies in scientific policy-making within healthcare. Health Technology Assessment (HTA) serves as a systematic approach to provide multi-dimensional evidence for optimizing decision-making in healthcare. While the general steps and methods of HTA can be applied to Traditional Medicine (TM), there are three challenging issues that need to be addressed for economic evaluation in TM: PICO structuring, cost measurement, and supportive clinical evidence and information collection.

INTEGRATIVE MEDICINE RESEARCH (2022)

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Review Oncology

Traditional Chinese medicine reverses cancer multidrug resistance and its mechanism

J. Wei et al.

Summary: Chemotherapy is widely used in cancer treatments, but Multidrug resistance (MDR) poses a challenge. Traditional Chinese medicines are known to be effective in reversing MDR due to their low toxicity, high efficacy, and safety.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

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Article Endocrinology & Metabolism

Human microbiome and metabolic health: An overview of systematic reviews

Nathalie Michels et al.

Summary: The microbiome plays a significant role in metabolic disorders like obesity, diabetes, and NAFLD, with high-quality systematic reviews revealing specific gut bacterial differences in these conditions and linking certain gut bacteria abundance to inflammation.

OBESITY REVIEWS (2022)

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Review Pharmacology & Pharmacy

Chinese Medicine as an Adjunctive Treatment for Gastric Cancer: Methodological Investigation of meta-Analyses and Evidence Map

Cuncun Lu et al.

Summary: This study analyzed 20 English-language meta-analyses, finding that combining traditional Chinese medicine with chemotherapy for gastric cancer may improve treatment outcomes and reduce adverse effects. However, the majority of included meta-analyses showed deficiencies in methodological quality, indicating a need for further improvements.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Mathematical & Computational Biology

A new taxonomy was developed for overlap across 'overviews of systematic reviews': A meta-research study of research waste

Carole Lunny et al.

Summary: This study aimed to assess the frequency and characteristics of overlapping overviews. The results showed that one third of overviews overlapped in content and a majority covered broad topic areas. This highlights the ongoing waste of research resources, time, and effort in the medical field.

RESEARCH SYNTHESIS METHODS (2022)

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Article Mathematical & Computational Biology

The application of AMSTAR2 in 32 overviews of systematic reviews of interventions for mental and behavioural disorders: A cross-sectional study

Karina Karolina De Santis et al.

Summary: This study assessed the application of AMSTAR2 tool in systematic reviews of interventions for mental and behavioural disorders, finding that most evaluations resulted in low confidence ratings, particularly for non-Cochrane reviews. Cochrane reviews were more likely to receive high confidence ratings compared to non-Cochrane reviews.

RESEARCH SYNTHESIS METHODS (2022)

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Editorial Material Medicine, General & Internal

Where to prospectively register a systematic review

Dawid Pieper et al.

Summary: The aim of this study was to identify and characterize current options for prospective registration of systematic reviews. The results showed five options, each with different characteristics and features. The research community should discuss sustainable financing models for non-profit operated registers.

SYSTEMATIC REVIEWS (2022)

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Review Integrative & Complementary Medicine

Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: A methodological investigation with evidence map

Ting-ting Lu et al.

Summary: This study evaluated the reporting and methodological quality of meta-analyses on acupuncture for migraine and summarized the evidence on the efficacy and safety of acupuncture for migraine. The included meta-analyses indicated that acupuncture was efficacious and safe in preventing and treating migraine. However, the reporting and methodological quality of these meta-analyses need improvement.

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2022)

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Article Health Policy & Services

Health technology assessment-informed pricing negotiation in China: higher negotiated price for more effective targeted anticancer medicines?

Cong Huang et al.

Summary: This study aims to compare the negotiated price and clinical benefit of selected targeted anticancer medicines (TAMs) and explore the application of health technology assessment (HTA) in the decision-making process.

HEALTH RESEARCH POLICY AND SYSTEMS (2022)

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Editorial Material Health Care Sciences & Services

More Thoughts than Answers: What Distinguishes Evidence-Based Clinical Practice Guidelines from Non-evidence-Based Clinical Practice Guidelines?

Xiaomei Yao et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2021)

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Article Health Care Sciences & Services

Authors should clearly report how they derived the overall rating when applying AMSTAR 2-a cross-sectional study

Dawid Pieper et al.

Summary: The study compared different schemes in deriving the overall confidence in AMSTAR 2 and found that the website scheme was the least strict, with no significant differences between the 5-item and 7-item schemes. Less than half of the publications included in the study reported how they derived the overall rating.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Review Urology & Nephrology

Value-Based Healthcare in Urology: A Collaborative Review

Chanan Reitblat et al.

Summary: The implementation of value-based healthcare in urology has shown promising results in improving guideline-compliant care, patient outcomes, and resource utilization. However, further research is needed to evaluate and measure the impact of value-based healthcare interventions on patient outcomes.

EUROPEAN UROLOGY (2021)

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Article Pharmacology & Pharmacy

Unlocking the Mystery of the Therapeutic Effects of Chinese Medicine on Cancer

Shao-Hsiang Liu et al.

Summary: The rise of cancer immunotherapy in the past decade has sparked increased public interest in cancer treatment methods. Traditional Chinese medicine has a long history of adjusting the body's health status and has shown positive effects in treating cancer by enhancing survival rates and life expectancies, although the pharmacological mechanisms are not fully understood.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Health Care Sciences & Services

Nearly 80 systematic reviews were published each day: Observational study on trends in epidemiology and reporting over the years 2000-2019

Falk Hoffmann et al.

Summary: There has been a more than 20-fold increase in the number of published systematic reviews over the past 20 years, with an equivalent of 80 systematic reviews published per day in 2019. Over time, systematic reviews have become more diverse in terms of journals, review types, and countries of corresponding authors.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Plant Sciences

Saffron (Crocus sativus L.) and health outcomes: a meta-research review of meta-analyses and an evidence mapping study

Cuncun Lu et al.

Summary: This study reviewed 19 systematic reviews with meta-analyses on saffron, indicating its significant effects on various clinical outcomes. However, the quality of these reviews needs improvement to confirm the clinical effects of saffron through high-quality randomized trials.

PHYTOMEDICINE (2021)

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Article Hematology

An epidemic of redundant meta-analyses

Celine Chapelle et al.

Summary: This study examined redundant meta-analyses in the same area using the same RCT data. The results showed that multiple studies using the same data led to similar conclusions. To address this issue, the development of living meta-analyses and encouraging authors to update meta-analyses in the same paper as their original research is suggested.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Review Pharmacology & Pharmacy

Evaluation of Efficacy and Safety for Kanglaite Injection in the Control of the Malignant Pleural Effusions via Thoracic Perfusion: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Guanghui Zhu et al.

Summary: The meta-analysis included 20 RCTs involving 1,291 patients. Intrapleural infusion with KLTI + chemotherapy drugs showed higher ORR in MPE treatment than chemotherapy alone. Combining KLTI with cisplatin or using 200ml of KLTI each time had advantages in improving ORR. Additionally, KLTI combined with chemotherapy drugs significantly improved QOL and reduced gastrointestinal and renal damage caused by chemotherapy drugs.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Medicine, General & Internal

PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

Matthew J. Page et al.

Summary: The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess trustworthiness. PRISMA 2020 aims to improve the transparency and completeness of systematic review reporting, in hopes of guiding more accurate and transparent reporting.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Health Care Sciences & Services

Global mapping of overviews of systematic reviews in healthcare published between 2000 and 2020: a bibliometric analysis

Konstantinos I. Bougioukas et al.

Summary: This study conducted a bibliometric analysis using a large sample of overviews of systematic reviews to reveal research trends and areas of interest. Results showed an increasing number of publications annually, with collaborations across countries in various scholarly journals, particularly in fields like complementary/alternative medicine, psychiatry/psychology, nutrition/dietetics, and pediatrics. The most common clinical conditions studied included depression, diabetes, cancer, dementia, pain, cardiovascular disease, stroke, obesity, and schizophrenia.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Article Health Care Sciences & Services

Clinical Epidemiology in China series. Paper 3: The methodological and reporting quality of systematic reviews and meta-analyses published by China' researchers in English-language is higher than those published in Chinese-language

Liujiao Cao et al.

Summary: The study observed that the reporting and methodological quality of English language systematic reviews and meta-analyses conducted by Chinese authors between 2016 and 2018 were slightly better than those of Chinese language publications.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Review Pharmacology & Pharmacy

Kanglaite Combined With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Therapy for Stage III/IV Non-Small Cell Lung Cancer: A PRISMA-Compliant Meta-Analysis

Fanming Kong et al.

Summary: The combination of Kanglaite (KLT) and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) showed significant efficacy in the treatment of stage III/IV non-small cell lung cancer, improving disease control rate, objective response rate, Karnofsky performance status, and enhancing patient immunity. Additional well-designed studies are needed to further confirm its efficacy and safety.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Oncology

The effect of kanglaite injection in combination with gefitinib versus gefitinib alone in patients with nonsmall cell lung cancer: A meta-analysis

He Hailang et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2020)

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Review Integrative & Complementary Medicine

Kanglaite Injection Combined with Chemotherapy versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients with Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Jianxia Wen et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Article Plant Sciences

Kanglaite injection plus platinum-based chemotherapy for stage III/IV non-small cell lung cancer: A meta-analysis of 27 RCTs

Xiaoming Huang et al.

PHYTOMEDICINE (2020)

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Review Multidisciplinary Sciences

Error rates of human reviewers during abstract screening in systematic reviews

Zhen Wang et al.

PLOS ONE (2020)

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Review Health Care Sciences & Services

Efficacy and safety of Kanglaite injection combined with first-line platinum-based chemotherapy in patients with advanced NSCLC: a systematic review and meta-analysis of 32 RCTs

Juan Li et al.

ANNALS OF PALLIATIVE MEDICINE (2020)

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Review Medicine, General & Internal

Guidance for overviews of reviews continues to accumulate, but important challenges remain: a scoping review

Michelle Gates et al.

SYSTEMATIC REVIEWS (2020)

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Review Medicine, General & Internal

Reporting of Multi-Arm Parallel-Group Randomized Trials Extension of the CONSORT 2010 Statement

Edmund Juszczak et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

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Review Critical Care Medicine

Industry sponsorship and research outcome: systematic review with meta-analysis

Andreas Lundh et al.

INTENSIVE CARE MEDICINE (2018)

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Article Medicine, General & Internal

AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both

Beverley J. Shea et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Article Medicine, General & Internal

AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both

Beverley J. Shea et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Article Medicine, General & Internal

Selecting and implementing overview methods: implications from five exemplar overviews

Alex Pollock et al.

SYSTEMATIC REVIEWS (2017)

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Article Oncology

Kanglaite injection combined with hepatic arterial intervention for unresectable hepatocellular carcinoma: A meta-analysis

Fei Fu et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2014)

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Article Oncology

Kanglaite injection combined with chemotherapy versus chemotherapy alone in the treatment of advanced non-small cell lung carcinoma

Xiaohong Liu et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2014)

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Article Oncology

Kanglaite stimulates anticancer immune responses and inhibits HepG2 cell transplantation-induced tumor growth

Xinli Huang et al.

MOLECULAR MEDICINE REPORTS (2014)

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Review Medicine, Research & Experimental

Kanglaite Injection Plus Chemotherapy Versus Chemotherapy Alone for Non-Small Cell Lung Cancer Patients: A Systematic Review and Meta-Analysis

Xuemei Liu et al.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL (2008)

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Article Mathematical & Computational Biology

Statistical methods for assessing the influence of study characteristics on treatment effects in 'meta-epidemiological' research

JAC Sterne et al.

STATISTICS IN MEDICINE (2002)

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