期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.920824
关键词
nanotechnology; nanomedicine; osteoarthritis; drug delivery system; treatment
资金
- Natural Science Foundation of Henan Province
- National Natural Science Foundation Youth Project of China
- Henan Young and Middle-aged Health Science and Technology Innovation Excellent Youth Talent Training Project of China
- [212300410242]
- [82002300]
- [YXKC2021047]
The article reviews the current treatment of osteoarthritis (OA) and summarizes the research advances of nanotechnology in OA treatment, including nano drug delivery systems, nano-scaffolds, and nanoparticle lubricants. The opportunities and potential challenges of nanotechnology in OA treatment are also discussed.
Osteoarthritis (OA) is a multifactorial disease that affects the entire joint, often resulting in severe pain, disability, psychological distress, and a lower quality of life. Patient self-management is emphasized in OA clinical recommendations. Currently, the clinical treatment of OA mainly focuses on pain relief and the improvement of joint function, with few options for regenerating degenerative cartilage or slowing the progression of OA. Therefore, we first reviewed the current treatment of OA, and then summarized the research advances of nanotechnology in OA treatment, including nano drug delivery systems for small molecule drugs, nucleic acids and proteins, nano-scaffolds for cartilage regeneration, and nanoparticle lubricants. Finally, we discussed the opportunities and potential challenges of nanotechnology in OA treatment.
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