Reconfiguration of static and dynamic thalamo-cortical network functional connectivity of epileptic children with generalized tonic-clonic seizures

Review Clinical Neurology

Epilepsy and brain network hubs

Jessica Royer et al.

Summary: Hubs, as key regions connecting different parts of the brain, play a critical role in brain network organization and related disorders.

EPILEPSIA (2022)

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Review Clinical Neurology

Deep brain stimulation targets in epilepsy: Systematic review and meta-analysis of anterior and centromedian thalamic nuclei and hippocampus

Artur Vetkas et al.

Summary: This systematic review and meta-analysis examined the efficacy of deep brain stimulation (DBS) in the treatment of drug-resistant epilepsy (DRE). The results showed that DBS is an effective and safe therapy for DRE, with the best evidence supporting its use for the anterior thalamic nucleus. Further research is needed to explore the efficacy of DBS for other targets such as the centromedian thalamic nucleus and hippocampus. Factors such as electrode location, stimulation parameters, type of epilepsy, and duration of stimulation are associated with clinical outcomes. Advances in anatomical targeting, functional neuroimaging, and sensing technology could potentially improve outcomes of DBS for epilepsy.

EPILEPSIA (2022)

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Article Neurosciences

Dynamic functional connectivity in modular organization of the hippocampal network marks memory phenotypes in temporal lobe epilepsy

Hong Li et al.

Summary: This study investigated the relationship between memory impairment and modular alterations in the hippocampal network of TLE patients. The results showed significant differences in modular properties between TLE-MD and TLE-MI patients in two distinct states, with dynamic modularity features having unique advantages in discriminating between the two memory phenotypes.

HUMAN BRAIN MAPPING (2022)

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Review Clinical Neurology

The role of thalamic nuclei in genetic generalized epilepsies

Annika Luettjohann et al.

Summary: This review summarizes data on the participation of different thalamic nuclei in genetic generalized epilepsies (GGE). The traditional 'three compartment model' on seizure generation is considered too simplistic as the thalamus cannot be seen as a unity. Different thalamic nuclei integrated in different thalamocortical and subcortical loops play different roles in seizure generation, generalization, and maintenance. The networks involved may vary between different classes of GGE patients and can even be antagonistic between seizure types.

EPILEPSY RESEARCH (2022)

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Article Neurosciences

Impaired Functional Homotopy and Topological Properties Within the Default Mode Network of Children With Generalized Tonic-Clonic Seizures: A Resting-State fMRI Study

Yongxin Li et al.

Summary: This study examined the interhemispheric functional connectivity and topological organization within the default-mode network (DMN) in children with generalized tonic-clonic seizures (GTCS). The results showed significant changes in connectivity and organization in the DMN of GTCS patients. Decreased homotopic coordination in the DMN can be used as an effective biomarker to reflect seizure effects and distinguish children with GTCS from typically developing children.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Medicine, General & Internal

Distinct Functional Cortico-Striato-Thalamo-Cerebellar Networks in Genetic Generalized and Focal Epilepsies with Generalized Tonic-Clonic Seizures

Hsinyu Hsieh et al.

Summary: This study examined the connectivity patterns in cortico-striato-thalamo-cerebellar networks in genetic generalized epilepsy and focal epilepsy with generalized tonic-clonic seizures. The results showed distinct connectivity differences in the thalamus and cerebellum between the two epilepsy syndromes, suggesting these regions may serve as imaging biomarkers for differential diagnosis. Machine learning algorithms achieved high accuracy in classifying the two syndromes based on network features.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Clinical Neurology

Altered dynamic functional network connectivity within default mode network of epileptic children with generalized tonic-clonic seizures

Yongxin Li et al.

Summary: The study identified two recurrent states in the DMN of children with GTCS, showing that compared to healthy controls, patients spent more time in a weakly connected State 1 and less time in a strongly connected State 2. The dynamic functional network connectivity strength within the DMN showed both increase and decrease in the patient group, and the changes were correlated with epilepsy duration.

EPILEPSY RESEARCH (2022)

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Article Neurosciences

Reconfiguration of Directed Functional Connectivity Among Neurocognitive Networks with Aging: Considering the Role of Thalamo-Cortical Interactions

Moumita Das et al.

Summary: This study reveals the crucial role of subcortical nodes, specifically the thalamus, in the reorganization of neurocognitive networks within and between the brain during aging. The thalamus acts as a key causal hub, influencing both within-network and between-network connectivity, and plays a significant role in maintaining cognitive functioning with age. Additionally, the thalamus serves as a causal integrative hub, exhibiting substantial interactions with neurocognitive networks as individuals age, which was replicated in an independent dataset of young and old individuals.

CEREBRAL CORTEX (2021)

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Article Neurosciences

Cortico-striato-thalamo-cerebellar networks of structural covariance underlying different epilepsy syndromes associated with generalized tonic-clonic seizures

Qiang Xu et al.

Summary: This study explored the brain network changes in patients with generalized tonic-clonic seizures (GTCS) and focal epilepsy associated with focal to bilateral tonic-clonic seizure (FE-FBTS) using structural covariance analysis, revealing differences between the two syndromes. Patients showed increased connectivity within the striatum and thalamus relative to healthy controls, with connectivity changes increasing as a function of epilepsy duration. FE-FBTS presented more severe network disruption compared to GE-GTCS.

HUMAN BRAIN MAPPING (2021)

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Article Clinical Neurology

Experience and consensus on stimulation of the anterior nucleus of thalamus for epilepsy

Alfonso Fasano et al.

Summary: Deep brain stimulation of the anterior nuclei of thalamus (ANT-DBS) is effective for reducing seizures in patients with temporal or frontal epilepsy refractory to at least two medications. Motivations for therapy renewal upon battery depletion include reduced seizures, improved quality of life, and reduction of severe seizures. Stimulation parameters are mainly guided by magnetic resonance imaging and typically follow parameters similar to the SANTE study, with initial stimulation amplitudes in the 2-3 V or mA range.

EPILEPSIA (2021)

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Article Neurosciences

Brain dynamics: Synchronous peaks, functional connectivity, and its temporal variability

Edmund T. Rolls et al.

Summary: Recent advancements in understanding brain dynamics have shed light on the operation of the cerebral cortex in both health and disease. Research shows that synchronized peaks in resting state fMRI BOLD signals can be observed in various brain areas, with early visual and connected areas having the highest probability of synchronization. Additionally, cortical areas with high likelihood of synchronized peaks and low temporal variability in connectivity are associated with high mean functional connectivity, contributing to our comprehension of cortical function in different conditions, including schizophrenia.

HUMAN BRAIN MAPPING (2021)

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Article Neurosciences

Distinct effects of the basal ganglia and cerebellum on the thalamocortical pathway in idiopathic generalized epilepsy

Jinnan Gong et al.

Summary: This study utilized diffusion and functional MRI to investigate the pathoglytic changes in the basal ganglia-thalamocortical and cerebellum-thalamocortical pathways in people with idiopathic generalized epilepsy (IGE). The findings revealed connectivity changes with perception and cognition systems and identified abnormal integration of sensorimotor and visual information in IGE. Aberrant functional and structural integration of cerebellum, basal ganglia, and thalamus were linked to cognitive impairment and epileptic activities in IGE.

HUMAN BRAIN MAPPING (2021)

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Review Clinical Neurology

Recent Advances in Neuroimaging of Epilepsy

Adam M. Goodman et al.

Summary: This review summarizes significant advancements in human neuroimaging techniques used in epilepsy research, focusing on the application of MRI, PET, and MEG technologies and highlighting the advantages of new techniques in clinical and research settings. Research covers the diagnosis of epilepsy, the relationships between network disorders and comorbidities, as well as new technologies and approaches expected to emerge in the next decade.

NEUROTHERAPEUTICS (2021)

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Article Multidisciplinary Sciences

The genetic architecture of the human thalamus and its overlap with ten common brain disorders

Torbjorn Elvsashagen et al.

Summary: Through a large-scale study using genetic and MRI data, the researchers identified genetic variations affecting thalamic and its nuclei volumes, validated the genetic relationship between the thalamus and cerebral cortex, and found associations with shared variants for ten psychiatric and neurological disorders.

NATURE COMMUNICATIONS (2021)

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Article Neurosciences

Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy

Yachin Chen et al.

Summary: This study found significant volume reduction of the left and right anterior thalamic nuclei only in patients with refractory idiopathic generalised epilepsy (IGE), compared to those with non-refractory IGE. Both refractory and non-refractory IGE patients showed significant alterations of functional connectivity between the centromedian nucleus and cortex, with only refractory patients showing altered cortical connectivity with the ventral lateral nuclear group. Refractory IGE patients had increased functional connectivity between the left and right ventral lateral posterior nuclei and cortical regions compared to non-refractory IGE patients, mainly in the frontal lobe.

HUMAN BRAIN MAPPING (2021)

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Article Neurosciences

Reconfiguration of dynamic large-scale brain network functional connectivity in generalized tonic-clonic seizures

Xiaoyan Jia et al.

HUMAN BRAIN MAPPING (2020)

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Article Neurosciences

Altered inter- and intrahemispheric functional connectivity dynamics in autistic children

Xiaonan Guo et al.

HUMAN BRAIN MAPPING (2020)

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Review Clinical Neurology

Default mode network dysfunction in idiopathic generalised epilepsy

Nicholas Parsons et al.

EPILEPSY RESEARCH (2020)

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Article Clinical Neurology

Thalamic and cortical hyperexcitability in juvenile myoclonic epilepsy

Giovanni Assenza et al.

CLINICAL NEUROPHYSIOLOGY (2020)

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Article Clinical Neurology

Impaired Topological Properties of Gray Matter Structural Covariance Network in Epilepsy Children With Generalized Tonic-Clonic Seizures: A Graph Theoretical Analysis

Yongxin Li et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Clinical Neurology

Dynamic analysis of fMRI activation during epileptic spikes can help identify the seizure origin

Magdalena A. Kowalczyk et al.

EPILEPSIA (2020)

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Article Behavioral Sciences

Disrupted topological properties of functional networks in epileptic children with generalized tonic-clonic seizures

Yongxin Li et al.

BRAIN AND BEHAVIOR (2020)

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Article Neurosciences

Impaired hippocampal functional connectivity in patients with drug resistant, generalized tonic-clonic seizures

Zhengge Wang et al.

NEUROREPORT (2019)

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Article Clinical Neurology

Community-informed connectomics of the thalamocortical system in generalized epilepsy

Zhengge Wang et al.

NEUROLOGY (2019)

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Review Clinical Neurology

Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks

Lucina Q. Uddin et al.

BRAIN TOPOGRAPHY (2019)

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Article Clinical Neurology

Alterations in the hippocampal-thalamic pathway underlying secondarily generalized tonic-clonic seizures in mesial temporal lobe epilepsy: A diffusion tensor imaging study

Cong Chen et al.

EPILEPSIA (2019)

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Article Neurosciences

Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network

Akhil Kottaram et al.

HUMAN BRAIN MAPPING (2019)

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Article Neurosciences

Development of short-range white matter in healthy children and adolescents

Adeoye A. Oyefiade et al.

HUMAN BRAIN MAPPING (2018)

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Article Clinical Neurology

Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study

Christopher D. Whelan et al.

BRAIN (2018)

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Article Neurosciences

Static and dynamic connectomics differentiate between depressed patients with and without suicidal ideation

Wei Liao et al.

HUMAN BRAIN MAPPING (2018)

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Article Clinical Neurology

Multimodal Data and Machine Learning for Detecting Specific Biomarkers in Pediatric Epilepsy Patients With Generalized Tonic-Clonic Seizures

Jianping Wang et al.

FRONTIERS IN NEUROLOGY (2018)

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Article Neurosciences

Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic-clonic seizure

Feng Liu et al.

HUMAN BRAIN MAPPING (2017)

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Article Clinical Neurology

Instruction manual for the ILAE 2017 operational classification of seizure types

Robert S. Fisher et al.

EPILEPSIA (2017)

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Article Neurosciences

The Human Thalamus Is an Integrative Hub for Functional Brain Networks

Kai Hwang et al.

JOURNAL OF NEUROSCIENCE (2017)

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Article Neurosciences

The dynamic functional connectome: State-of-the-art and perspectives

Maria Giulia Preti et al.

NEUROIMAGE (2017)

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Article Clinical Neurology

Alterations in Spontaneous Brain Activity and Functional Network Reorganization following Surgery in Children with Medically Refractory Epilepsy: A Resting-State Functional Magnetic Resonance Imaging Study

Yongxin Li et al.

FRONTIERS IN NEUROLOGY (2017)

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Article Neurosciences

Disrupted structural and functional rich club organization of the brain connectome in patients with generalized tonic-clonic seizure

Rong Li et al.

HUMAN BRAIN MAPPING (2016)

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Article Computer Science, Interdisciplinary Applications

DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging

Chao-Gan Yan et al.

NEUROINFORMATICS (2016)

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Article Clinical Neurology

Identifying Corticothalamic Network Epicenters in Patients with Idiopathic Generalized Epilepsy

G. -J. Ji et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2015)

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Article Behavioral Sciences

Altered functional connectivity among default, attention, and control networks in idiopathic generalized epilepsy

H. L. Wei et al.

EPILEPSY & BEHAVIOR (2015)

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Article Clinical Neurology

Early and Late Age of Seizure Onset have a Differential Impact on Brain Resting-State Organization in Temporal Lobe Epilepsy

Gaelle E. Doucet et al.

BRAIN TOPOGRAPHY (2015)

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Article Clinical Neurology

Diffusional kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epilepsy

C. -Y. Lee et al.

ACTA NEUROLOGICA SCANDINAVICA (2014)

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Article Neurosciences

Tracking Whole-Brain Connectivity Dynamics in the Resting State

Elena A. Allen et al.

CEREBRAL CORTEX (2014)

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Article Clinical Neurology

Altered thalamocortical functional connectivity in idiopathic generalized epilepsy

Jung Bin Kim et al.

EPILEPSIA (2014)

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Article Radiology, Nuclear Medicine & Medical Imaging

Generalized Tonic-Clonic Seizures: Aberrant Interhemispheric Functional and Anatomical Connectivity

Gong-Jun Ji et al.

RADIOLOGY (2014)

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Article Neuroimaging

Functional neuroimaging abnormalities in idiopathic generalized epilepsy

Megan L. McGill et al.

NEUROIMAGE-CLINICAL (2014)

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Article Neurosciences

DynamicBC: A MATLAB Toolbox for Dynamic Brain Connectome Analysis

Wei Liao et al.

BRAIN CONNECTIVITY (2014)

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Article Multidisciplinary Sciences

Disrupted Causal Connectivity in Mesial Temporal Lobe Epilepsy

Gong-Jun Ji et al.

PLOS ONE (2013)

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Article Neurosciences

Resting state basal ganglia network in idiopathic generalized epilepsy

Cheng Luo et al.

HUMAN BRAIN MAPPING (2012)

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Article Multidisciplinary Sciences

Impairments of Thalamic Nuclei in Idiopathic Generalized Epilepsy Revealed by a Study Combining Morphological and Functional Connectivity MRI

Zhengge Wang et al.

PLOS ONE (2012)

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Article Neurosciences

Altered resting state networks in epileptic patients with generalized tonic-clonic seizures

Zhengge Wang et al.

BRAIN RESEARCH (2011)

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Article Clinical Neurology

Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009

Anne T. Berg et al.

EPILEPSIA (2010)

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Review Clinical Neurology

Exploring the brain network: A review on resting-state fMRI functional connectivity

Martijn P. van den Heuvel et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2010)

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Article Neurosciences

Thalamo-cortical network pathology in idiopathic generalized epilepsy: Insights from MRI-based morphometric correlation analysis

Boris C. Bernhardt et al.

NEUROIMAGE (2009)

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Review Behavioral Sciences

Idiopathic epileptic syndromes and cognition

C Hommet et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2006)

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Article Multidisciplinary Sciences

The human brain is intrinsically organized into dynamic, anticorrelated functional networks

MD Fox et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Multidisciplinary Sciences

A default mode of brain function

ME Raichle et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Reconfiguration of static and dynamic thalamo-cortical network functional connectivity of epileptic children with generalized tonic-clonic seizures

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