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A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures

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Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice

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Summary: Previous studies have shown that BDNF is involved in enhancing synaptic transmission in the hippocampus, but less is known about its effects in the anterior cingulate cortex (ACC). In this study, it was demonstrated that BDNF enhances synaptic responses in the ACC in a dose-dependent manner, with the enhancement lasting at least 3 hours. The enhancement was found to be mediated by TrkB receptors, L-VGCC, mGluRs, and AC1 signaling pathways, and was shown to occlude TBS-induced LTP. The expression of BDNF-induced enhancement in the ACC was found to depend on the incorporation of CP-AMPARs and PKM zeta.

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