4.5 Article

Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.871679

关键词

time of day-dependent; hippocampal Rac1 activity; contextual fear learning; memory retrieval; melatonin

向作者/读者索取更多资源

Fear memory in different species shows time-dependent alterations. This study found that training during the lower activation period of hippocampal Rac1 at night improves contextual fear memory in rats. Exogenous melatonin treatment enhances Rac1 activity and impairs fear memory acquisition during the night, while a Rac1-specific inhibitor attenuates the effect of melatonin.
Fear memory in species varies according to the time of the day. Although the underlying molecular mechanisms have been extensively explored, they remain largely unknown. Here, we report that hippocampal Rac1 activity undergoes a time of day-dependent alteration both in nocturnal rats and diurnal tree shrews and that training at the lower hippocampal Rac1 activation period during the night leads to better contextual fear memory in rats. Furthermore, day and night reversion by 24 h darkness/24 h light housing inverses the external clock time of hippocampal Rac1 activation, but the better contextual fear memory still coincides with the lower Rac1 activation in rats during the night. Interestingly, exogenous melatonin treatment promotes hippocampal Rac1 activity and impairs better contextual fear memory acquired at the lower Rac1 activation period during the night, and Rac1-specific inhibitor NSC23766 compromises the effect of melatonin. These results suggest that the time of day-dependent alteration of hippocampal Rac1 activation regulates contextual fear memory in rats by forgetting.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据