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Article
Microbiology
Hongjie Xia et al.
Summary: Two doses of the BNT162b2 mRNA vaccine demonstrate high efficacy against SARS-CoV-2 and also provide neutralization against Omicron SARS-CoV-2. The study shows that the neutralization response improves with the third dose, but decreases slightly after four months.
CELL HOST & MICROBE
(2022)
Article
Infectious Diseases
Frederik Plesner Lyngse et al.
Summary: This observational study in Denmark investigated the transmission of SARS-CoV-2 within households during the early stages of the COVID-19 pandemic. The study found a high transmission risk and attack rate within households, with an increasing risk with age and the ability of children to transmit the virus.
Article
Multidisciplinary Sciences
Jing Zou et al.
Summary: The spread of the Omicron SARS-CoV-2 variant highlights the importance of analyzing the cross-protection provided by previous non-Omicron infections. A new study shows that patients with prior non-Omicron infections do not develop strong neutralization against Omicron. This supports the vaccination of previously infected individuals to mitigate the impact of the ongoing Omicron surge.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Philippe Colson et al.
Summary: Multiple SARS-CoV-2 variants have been spreading worldwide since the summer of 2020. In this study, three infections in southern France with a Delta-Omicron recombinant were reported. The hybrid genome contains signature mutations of two lineages and shows high nucleotide diversity. The recombinant virus was successfully cultured and observed using scanning electron microscopy. A specific duplex qPCR was designed for routine diagnosis of this recombinant virus, which is misidentified by current variant screening methods. Structural analysis suggests that the hybrid content of the recombinant spike protein could enhance viral binding to host cells. Further studies are needed to investigate the virological, epidemiological, and clinical features of this recombinant virus.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Andrew D. Redd et al.
Summary: This study found that the newly identified Omicron variant of concern contains only one mutation in a low-prevalence epitope targeted by CD8(+) T cells, suggesting that the T-cell immune response in previously infected and vaccinated individuals should still be effective against Omicron.
Article
Multidisciplinary Sciences
Jing Zou et al.
Summary: The Omicron SARS-CoV-2 virus has multiple sublineages, with BA.1 being responsible for the initial surge and now being replaced by BA.2 globally. Understanding the cross-neutralization between these sublineages is important. Research shows that sera from BA.1-infected individuals have weaker neutralizing abilities against BA.2, BA.3, and USA/WA1-2020 compared to BA.1. This has implications for COVID-19 vaccine strategies.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Chaitanya Kurhade et al.
Summary: This study found that sera from individuals vaccinated with three doses of BNT162b2 have lower neutralization efficacy against Omicron BA.1, BA.2, and BA.3 compared to the original strain USAWA1/2020. The results have implications for vaccine strategy and understanding the biology of Omicron sublineages.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xuping Xie et al.
Summary: The study found that human sera from recipients of the BNT162b2 vaccine can neutralize SARS-CoV-2 viruses containing key spike mutations from the newly emerged UK and SA variants.
Article
Biochemical Research Methods
Xuping Xie et al.
Summary: Reverse genetic system for SARS-CoV-2 is essential for studying viruses, developing vaccines, and screening antiviral drugs. However, manipulating the system is complex due to the large size of the coronavirus genome and toxic genomic elements, requiring a meticulous six-step process. Mastering this system will accelerate COVID-19 research across different scientific fields.
Letter
Medicine, General & Internal
Yang Liu et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Letter
Medicine, General & Internal
Ann R. Falsey et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Microbiology
Xuping Xie et al.
CELL HOST & MICROBE
(2020)
Article
Multidisciplinary Sciences
Mark J. Mulligan et al.
Article
Medicine, General & Internal
Edward E. Walsh et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
