4.7 Article

Human Borna disease virus 1 encephalitis shows marked pro-inflammatory biomarker and tissue immunoactivation during the course of disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Arginase-1 Released into CSF After Aneurysmal Subarachnoid Hemorrhage Decreases Arginine/Ornithine Ratio: a Novel Prognostic Biomarker

Julian Zimmermann et al.

Summary: In aneurysmal subarachnoid hemorrhage (SAH), the enzyme arginase-1 is released into cerebrospinal fluid, leading to dysregulated metabolism of L-arginine. The levels of arginase-1 and the Arg/Orn ratio are associated with the occurrence of cerebral vasospasm syndrome (CVS), providing a novel prognostic biomarker for SAH.

TRANSLATIONAL STROKE RESEARCH (2022)

Article Immunology

Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany

Christina Frank et al.

Summary: In 2021, three cases of encephalitis caused by Borna disease virus 1 (BoDV-1) were diagnosed in Germany. These cases were from different states, with two being acute infections and one being diagnosed retrospectively. The report emphasizes the importance of testing for BoDV-1 in encephalitis cases in areas with known animal Borna disease endemicity in Europe.

EMERGING MICROBES & INFECTIONS (2022)

Article Cell Biology

Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections

Bernhard Neumann et al.

Summary: This article reports a case of fatal BoDV-1 infection and the development of a new sensitive diagnostic tool. The results demonstrate the importance of early detection of BoDV-1 RNA in cerebrospinal fluid and antibody responses to multiple viral antigens for the diagnosis of BoDV-1.

CELL REPORTS MEDICINE (2022)

Article Multidisciplinary Sciences

Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington's disease

Zhen-Yi Andy Ou et al.

Summary: This study found that BDNF concentration in plasma and cerebrospinal fluid is unlikely to be a biomarker for Huntington's disease progression, and caution is needed when interpreting studies using conventional ELISA to quantify BDNF.

SCIENTIFIC REPORTS (2021)

Article Immunology

Introduction and spread of variegated squirrel bornavirus 1 (VSBV-1) between exotic squirrels and spill-over infections to humans in Germany

Daniel Cadar et al.

Summary: The study explores the emergence and spread of VSBV-1 in European squirrel populations, highlighting the potential introduction pathway and role of animal trade. It also emphasizes the importance of molecular epidemiology in understanding zoonotic virus transmission and the urgent need for improved regulation and control strategies in response to emerging zoonotic diseases.

EMERGING MICROBES & INFECTIONS (2021)

Article Multidisciplinary Sciences

Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain

Fabien Dachet et al.

Summary: By comparing postmortem brains to fresh human neocortex, researchers observed that fresh brain samples had a unique transcriptional pattern with a rapid decrease in neuronal activity-dependent transcripts and an increase in glial gene expression. These dynamic transcriptional and cellular changes during the postmortem interval are crucial for interpreting research on human brain disorders.

SCIENTIFIC REPORTS (2021)

Article Infectious Diseases

Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany - a case report

Dennis Tappe et al.

Summary: A fatal case of encephalitis in a farmer in northeast Germany was found to be caused by BoDV-1 through laboratory investigation, with the virus cluster not known to be endemic in the region. The investigation was triggered by an outbreak of animal Borna disease, highlighting the need for increased clinical awareness for human BoDV-1 encephalitis.

BMC INFECTIOUS DISEASES (2021)

Article Microbiology

Genomic and Micro-Evolutionary Features of Mammalian 2 orthobornavirus (Variegated Squirrel Bornavirus 1, VSBV-1)

Daniel Cadar et al.

Summary: Research on VSBV-1 reveals that its genetic diversity is primarily shaped by in situ evolution, with evidence of adaptive evolution in the G and L genes. The main mechanism of virus spread is through animal trade, leading to local micro-evolution in zoos and holdings.

MICROORGANISMS (2021)

Article Immunology

Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018-2020

Philip Eisermann et al.

Summary: This study investigated bornavirus etiology of encephalitis cases in Germany, identifying 4 cases related to variegated squirrel bornavirus and Borna disease virus through serological testing. These infections caused by the two viruses are severe and often fatal, especially in virus-endemic areas and with animal exposure.

EMERGING INFECTIOUS DISEASES (2021)

Article Clinical Neurology

Bornavirus Encephalitis Shows a Characteristic Magnetic Resonance Phenotype in Humans

Tom Finck et al.

ANNALS OF NEUROLOGY (2020)

Article Clinical Neurology

CSF VEGF Was Positively Associated with Neurogranin Independent of β-Amyloid Pathology

Yangping Huang et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2020)

Letter Clinical Neurology

Severe bornavirus-encephalitis presenting as Guillain-Barre-syndrome

Roland Coras et al.

ACTA NEUROPATHOLOGICA (2019)

Article Clinical Neurology

The neuropathology of fatal encephalomyelitis in human Borna virus infection

Friederike Liesche et al.

ACTA NEUROPATHOLOGICA (2019)

Letter Medicine, General & Internal

Fatal Encephalitis Associated with Borna Disease Virus 1

Klaus Korn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Letter Medicine, General & Internal

Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients

Kore Schlottau et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Immunology

Reactive Astrocytes: Production, Function, and Therapeutic Potential

Shane A. Liddelow et al.

IMMUNITY (2017)

Article Immunology

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Li Zhong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow et al.

NATURE (2017)

Article Multidisciplinary Sciences

Systematic analysis of gene expression patterns associated with postmortem interval in human tissues

Yizhang Zhu et al.

SCIENTIFIC REPORTS (2017)

Review Pharmacology & Pharmacy

Microglial M1/M2 polarization and metabolic states

Ruben Orihuela et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Review Neurosciences

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Yu Tang et al.

MOLECULAR NEUROBIOLOGY (2016)

Review Veterinary Sciences

The pathogenesis of bornaviral diseases in mammals

Ian Tizard et al.

ANIMAL HEALTH RESEARCH REVIEWS (2016)

Article Medicine, General & Internal

A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis

Bernd Hoffmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews

Daniel Nobach et al.

PLOS ONE (2015)

Review Neurosciences

The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer's Disease

Magdalena Groblewska et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Review Immunology

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

Jonathan D. Cherry et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Article Immunology

Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection

Mikhail V. Ovanesov et al.

JOURNAL OF NEUROINFLAMMATION (2008)

Article Clinical Neurology

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis

S. Z. Lepej et al.

ACTA NEUROLOGICA SCANDINAVICA (2007)

Article Virology

Activation of microglia by Borna disease virus infection: In vitro study

Mikhail V. Ovanesov et al.

JOURNAL OF VIROLOGY (2006)

Article Biochemistry & Molecular Biology

A new mathematical model for relative quantification in real-time RT-PCR

MW Pfaffl

NUCLEIC ACIDS RESEARCH (2001)