Prognostic features and comprehensive genomic analysis of NF1 mutations in EGFR mutant lung cancer patients

Article Clinical Neurology

Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish

Juanjuan Luo et al.

Summary: The research indicates that combined deletions of nf1, tp53, and rb1 genes in zebrafish greatly promote gliomagenesis, with these glioma models showing relevance to temozolomide treatment.

BRAIN (2021)

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Article Oncology

MA09.07 Genomic Landscape and Clinical Outcomes With Immune Checkpoint Inhibitors in NF1-Mutant NSCLC

M. Negrao et al.

Journal of Thoracic Oncology (2021)

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Article Oncology

Bevacizumab plus erlotinib in Chinese patients with untreated, EGFR-mutated, advanced NSCLC (ARTEMIS-CTONG1509): A multicenter phase 3 study

Qing Zhou et al.

Summary: Dual inhibition of EGFR and VEGF pathways may delay therapeutic resistance in NSCLC, and a study on the efficacy and safety of erlotinib plus bevacizumab regimen in untreated patients showed significantly prolonged PFS, indicating potential benefits in advanced NSCLC treatment.

CANCER CELL (2021)

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Article Oncology

Accurate Prognosis Prediction of Pancreatic Ductal Adenocarcinoma Using Integrated Clinico-Genomic Data of Endoscopic Ultrasound-Guided Fine Needle Biopsy

Joo Kyung Park et al.

Summary: This study aimed to evaluate the feasibility of targeted sequencing using minimal specimens obtained from endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) for predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). Clinical prognostic factors and genetic alterations were identified and used to establish a clinico-genomic model for predicting patient outcomes in PDAC. Targeted deep sequencing on minimal specimens of PDAC was performed, and a clinico-genomic model for prognosis prediction was developed based on 20 single nucleotide variants and three copy number variations.

CANCERS (2021)

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Article Oncology