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Review
Allergy
Mitsutoshi Tominaga et al.
Summary: Atopic dermatitis is a skin disorder characterized by dryness and dysfunction of the skin barrier, leading to inflammation and chronic itch. The itch sensation is sensitized by the increase in intraepidermal nerve fibers and the secretion of IL-33 by keratinocytes. The breakdown of the skin barrier allows allergens to enter the epidermis, triggering type 2 inflammatory responses and worsening itch. Controlling itch is crucial for the treatment of atopic dermatitis.
ALLERGOLOGY INTERNATIONAL
(2022)
Review
Allergy
Makoto Kadowaki et al.
Summary: The nervous system and the immune system play important roles in maintaining physiological homeostasis and protecting against external threats. Recent research has shown that there is close interaction and communication between neurons and immune cells, which may be involved in the pathophysiology of allergic diseases.
ALLERGOLOGY INTERNATIONAL
(2022)
Review
Allergy
Misato Irie et al.
Summary: The neural and immune systems are closely connected, and neuropeptides have been found to regulate ILC2 cells, which are independent of acquired immunity. However, the complete mechanisms of this regulation are not fully understood yet. This review summarizes the current reports on the regulatory effects of neuropeptides on ILC2 cells, which have conflicting results possibly due to the complexity of G-protein coupled receptors.
ALLERGOLOGY INTERNATIONAL
(2022)
Review
Allergy
Shota Toyoshima et al.
Summary: Mast cells and nerve fibers have anatomical and functional cross-talk, playing important roles in allergic inflamed tissues.
ALLERGOLOGY INTERNATIONAL
(2022)
Editorial Material
Biochemistry & Molecular Biology
Esther B. Florsheim et al.
Summary: Food serves as a crucial source of nutrients as well as potential toxins and pathogens. Various sensory mechanisms have evolved to monitor food quality, with allergic immunity also playing a role in controlling food quality by defending against food antigens associated with harmful substances. Exaggeration of these defenses can lead to pathological food allergies.
Review
Immunology
Marie Tauber et al.
Summary: Peripheral neurons play a crucial role in transmitting sensations and regulating type 2 immune responses and allergic inflammation. Neurons can express receptors previously thought to be exclusive to the immune system, and interact with immune cells to modulate their activation status during allergic inflammation.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Review
Allergy
Vanitha Sampath et al.
Summary: The prevalence of food allergy is increasing in some areas, calling for better strategies for prevention, diagnosis, and therapy. Significant progress has been made in understanding the causes of food allergies, leading to updated guidelines recommending early introduction of allergenic foods and the approval of oral immunotherapy drugs for FA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Franz J. Legat
Summary: Atopic dermatitis is a common inflammatory skin disease affecting up to 20% of children and 10% of adults in higher income countries, with chronic pruritus as a major symptom causing significant impact on quality of life. New systemic and topical treatments targeting specific cytokines and receptors have ushered in a new era in atopic dermatitis and pruritus therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
GM Story et al.
