4.6 Review

Engineering Organ-on-a-Chip to Accelerate Translational Research

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A multi-organ chip with matured tissue niches linked by vascular flow

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Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery

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A guide to the organ-on-a-chip

Chak Ming Leung et al.

Summary: This article introduces the basic concepts, applications, and development trends of organ-on-chip (OoC) technology, as well as factors to consider when developing application-specific OoCs.

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Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

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Summary: PDMS is commonly used in organ-on-a-chip devices and microphysiological systems due to its ease-of-use, elasticity, and optical transparency, but its limitations in the absorption of small molecules and high-throughput manufacturing have led researchers to explore alternative materials such as elastomers, hydrogels, and thermoplastic polymers. The development of organ-on-a-chip devices based on these alternative materials is trending, with researchers focusing on overcoming obstacles to create versatile devices for personalized medicine and drug discovery.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Organs-on-chips: into the next decade

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Summary: OoCs, also known as microphysiological systems or 'tissue chips', have the potential to be informative at multiple stages of drug discovery and development, providing insights into normal human organ function and disease pathophysiology, as well as predicting the safety and efficacy of investigational drugs in humans. The field of OoCs has seen significant advances in recent years, but there are still challenges and opportunities that need to be addressed to fully realize their potential for translational research.

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The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform

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Human bone marrow-derived mesenchymal stem cells play a role as a vascular pericyte in the reconstruction of human BBB on the angiogenesis microfluidic chip

Sumin Kim et al.

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Human biomimetic liver microphysiology systems in drug development and precision medicine

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Recent advances in microfluidic technology and applications for anti-cancer drug screening

Yiwei Shi et al.

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Adoption of organ-on-chip platforms by the pharmaceutical industry

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Anchor-IMPACT: A standardized microfluidic platform for high-throughput antiangiogenic drug screening

Suryong Kim et al.

Summary: In vitro models are advancing, with organ-on-a-chip devices providing significant results but requiring further development. Anchor-IMPACT is a 3D anchor-based microfluidic injection-molded plastic array culture platform that enables selective 3D cell patterning for high-throughput angiogenesis evaluation.

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Summary: The advancement of miniaturization techniques has had a significant impact on various research fields, including bioengineering. The development of 3D cell culture environments and organ-on-chip technologies has provided new possibilities for cell and tissue culture, disease modeling, and drug discovery. While these technologies offer potential alternatives to traditional methods, they also present challenges that require interdisciplinary studies for further development.

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Summary: The emerging microfluidic technology shows great potential in designing anti-cancer drugs and point-of-care diagnostics, offering advantages such as high-throughput drug screening, small sample requirements, in vivo-like environment for cells, and overcoming ethical issues associated with animal studies. Multiple cell cultures in microfluidic chips can better mimic the 3D tumor environment with low reagent consumption, and clinical experiments have revealed that combinatorial drug treatments are more effective than monodrug therapy. Numerous research efforts have been made in this field in the past decade, highlighting the future clinical applications of microfluidic systems in anti-cancer drug development.

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